İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Güncel Gönderiler
Adenomyosis and uterine fibroids: Two distinct yet overlapping clinical entities
(MDPI Publishing, 2026) Pecorella, Giovanni; Morciano, Andrea; Medvediev, Mykhailo; Sparic, Radmila; Bıyık, İsmail; Aydın, Gerçek; Baldini, Giorgio Maria; Malvasi, Antonio; Stojković, Marta; Tinelli, Andrea
Adenomyosis and uterine fibroids are among the most common benign uterine disorders in women of reproductive age and represent major causes of abnormal uterine bleeding, pelvic pain, and infertility. Despite their distinct histopathological features, they frequently coexist and share several hormonal and molecular mechanisms, making diagnosis and treatment challenging. This narrative review examines the current evidence on their epidemiology, pathophysiology, clinical presentation, imaging characteristics, reproductive impact, and therapeutic management, with particular attention to the role of imaging in the differential diagnosis and management of coexisting disease. A non-systematic narrative review of the literature was conducted using PubMed/MEDLINE and Scopus. Relevant original studies, systematic reviews, meta-analyses, consensus statements, and clinical guidelines addressing adenomyosis, uterine fibroids, imaging, fertility, and treatment were considered. Additional references were identified through manual screening of the bibliographies of the retrieved articles. Although adenomyosis and uterine fibroids differ in their biological origin and morphological appearance, they commonly present with overlapping symptoms, including heavy menstrual bleeding, dysmenorrhea, chronic pelvic pain, and reproductive dysfunction. Transvaginal ultrasound remains the first-line imaging modality, whereas magnetic resonance imaging is particularly valuable in complex cases, lesion characterization, and preoperative assessment. Accurate imaging phenotyping may help distinguish isolated from coexisting disease and support individualized medical, surgical, or minimally invasive treatment planning. A structured imaging-based approach integrated with clinical findings and reproductive goals may improve disease characterization and support individualized management of adenomyosis and uterine fibroids. Further standardization of imaging criteria and validation of emerging diagnostic technologies may improve patient stratification and treatment selection.
On the effectiveness of the weighted least squares technique for urban scaling: Empirical evidence on the relationship between labor productivity and city size in the u.s., europe, and latin america
(Springer Nature Link, 2026) Dingeç, Kemal Dinçer; Börü, Furkan; Tahsin, Emine
The cities are the places where scale economies are created. Therefore economics of agglomeration is important to understand different aspects of urbanization. The principles of agglomeration economies can be quantified by scaling analysis. The standard statistical method for scaling analysis is simple linear regression (ordinary least squares). However, the special characteristics of city data such as non-normal ity and non-constant variance (heteroskedasticity) complicate the statistical estima tion and make it necessary to use special estimation techniques. In this paper, to overcome these problems, the standard approach of utilizing the classical weighted least square technique is suggested. The novelty of the paper is the derivation of a specific weighting rule starting from a lognormal model of the individual-level metric. We applied the ordinary least squares (OLS) and the weighted least squares (WLS) technique for the investigation and comparison of the scaling behaviors of labor productivities in the cities of three different regions (Latin America, Europe, and the USA). It is revealed that while in the US and Europe OLS and WLS yield similar results, the OLS is incapable of detecting the scaling behavior in Latin America. The WLS is capable of identifying the “increasing return to scale” rela tionship between city size and labor productivity.
Structural and functional impact of lingual frenulum alterations on oral and craniofacial development in children during the mixed dentition stage
(Springer Nature Link, 2026) Vural, Yasemin; Esentürk, Gülce; Önder, Ömer Önder; Cebeci, Nesrin; Özen, Buğra
Background The clinical relevance of ankyloglossia in children remains controversial, largely due to the absence of standardized diagnostic criteria and the predominant reliance on morphological assessment. Evidence linking the combined anatomical and functional characteristics of the lingual frenulum to objective functional outcomes during mixed dentition remains limited. Therefore, this study aimed to evaluate the association between lingual frenulum characteristics and oral and craniofacial functional outcomes in children during the mixed dentition period. Methods In this cross-sectional study, 170 children aged 7–12 years were evaluated. Anatomical and functional characteristics of the lingual frenulum were assessed using the Marchesan Lingual Frenulum Protocol. Oro facial functions, including breathing pattern, mentalis muscle activity, and swallowing, were examined using selected components of the Orofacial Myofunctional Evaluation with Scores (OMES/OMES-E). Upper airway patency was evaluated using the Mallampati and Brodsky classifications, malocclusion was assessed clinically, and postural alignment was analyzed using the New York Posture Scale. Intergroup comparisons were performed (p < 0.05). Multivariate logistic regression analyses were conducted to identify independent predictors of swal lowing dysfunction. Results Maximum mouth opening did not differ significantly between groups (p = 0.137). However, reduced tongue range of motion (≤ 50%) was significantly more frequent in children with an altered frenulum (p < 0.001). No significant differences were observed in respiratory pattern, mentalis muscle activity, Mallampati or Brodsky scores (p > 0.05). Swallowing-related dysfunction, involving lip (p = 0.012) and tongue (p = 0.002) behavioral alterations, as well as malocclusion (p = 0.010), were significantly more prevalent in the altered frenulum group. Regression analyses demonstrated that altered frenulum independently predicted tongue-related swallowing dysfunction (OR = 2.513, p = 0.015), whereas breathing disturbance showed the strongest independent predictor (OR = 5.249, p < 0.001). Conclusion Lingual frenulum morphology was associated with reduced tongue mobility and domain-specific functional impairments, particularly in swallowing. These findings support the integration of functional evalua tion alongside structural assessment in the clinical management of ankyloglossia.
Reusable photo-crosslinked acrylate networks incorporating coumarin and S-CQDs for trace-level picric acid detection
(Elsevier, 2026) Toprak, Yunus Emre; Bulut, Mustafa; Artuç, Gamze Özgül; Uyumaz Cengiz, Fatmanur; Çubuk, Soner; Kahraman, Memet Vezir
Translating liquid-based luminescent nanomaterials into functional solid-state systems remains a major hurdle in environmental analysis. To address this limitation, this work presents the development of a structurally durable, multi-component polymeric sensor specifically engineered for the trace-level recognition of picric acid (PA). The sensing platform was formulated by embedding heteroatom-modified carbon nanodots (S-CQDs) alongside a custom-synthesized acrylated coumarin precursor within a tightly cross-linked UV-cured acrylate matrix. By confining the active phase within this polymeric architecture, the water-dispersible quantum dots are retained within a solid support while preserving their luminescent behavior. Upon exposure to PA, the formulated composite film (F2) exhibits pronounced fluorescence attenuation. The observed quenching is interpreted as an association-assisted process with possible contributions from photoinduced electron transfer (PET) and spectral- overlap-related effects. Under the optimized conditions, the sensor exhibited a linear response over 9.70 × 10 8–4.05 ×10 6 mol L 1 (R2 =0.9924), with a limit of detection of 2.25 ×10 8 mol L 1, a limit of quanti fication of 7.50 ×10 8 mol L 1, and a response time of approximately 20 s. The F2 film showed preferential fluorescence quenching toward PA compared with the investigated metal ions, aromatic species, and nitro aromatic compounds. The film retained approximately 95% of its baseline emission after 150 sensing/regener ation cycles and after two months of ambient storage. Practical applicability was demonstrated using real soil samples spiked with PA prior to extraction, yielding recoveries of 98.5–102.4% with RSD values of 1.4–2.1%. These results support the use of the S-CQD/acrylated-dicoumarin acrylate film as a reusable solid-state fluo rescence platform for PA determination.
Thermodynamic performance of a compression-ignition engine fueled with a diesel–fuel oil blend with nanographene addition and oxyhydrogen enrichment: Energy and exergy analysis
(Elsevier, 2026) Arslan, Ömer; Özer, Salih; Doğan, Battal; Tunçer, Erdal
This study examines how adding nanographene and enriching with oxyhydrogen (HHO) affect the energy and exergy performance of diesel–fuel oil blends in a compression-ignition engine. Nanographene was introduced to the DF40 blend (60% diesel, 40% fuel oil by volume) at 50 and 100 ppm, and HHO was supplied to the intake manifold at 5 and 10 L min 1 . Engine tests were performed at 3000 rpm with loads ranging from 3.2 to 12.8 Nm. The combined use of nanographene and HHO enhanced thermodynamic performance. At a load of 7.9 Nm, thermal and exergy efficiencies increased from 20.53% and 19.25% for DF40 to 25.80% and 23.72% for DF40N100H10, respectively. Maximum thermal and exergy efficiencies reached 31.66% and 29.11% at 12.8 Nm, while exergy destruction decreased by up to 23.1%. These results demonstrate the potential of nanographene addition and HHO enrichment to improve the thermodynamic performance of diesel–fuel oil blends under the tested conditions.
