İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Evaluation of the psychosocial aspects of the patients applying to the university cosmetology unit
(Unico's Medicine, 2026) Oraloğlu, Göktürk; Kuman Tunçel, Özlem; Elbi, Hayriye; Sağduyu, Ahmet Afşin; Ertam Sağduyu, İlgen
Objective: It is important to evaluate cosmetic patients psychologically and thus minimize potential adverse psychological outcomes that may occur after the procedure. This study aimed to investigate the psychosocial parameters in cosmetic patients. Materials and methods: Female patients (≥18 years old) who applied to the Ege University Dermatology and Venereal Diseases Department Cosmetology Unit were selected. ''Hospital Anxiety and Depression Scale'', ''Body Image Coping Strategies Inventory'', ''Temperament and Character Inventory'', ''Dermatology Quality of Life Index'' and ''Life Events' Checklist-5 '' forms were applied to the patients. The obtained data were analyzed statistically. Results: There were 36 people in the case group and 34 participants in the control group. A statistically significant difference was not found regarding life quality, anxiety, body image disturbance, and personally experienced life events between the two groups. Reward dependence, empathy, and purposefulness were significantly higher in the cosmetic group. Conclusion: The life quality was not negatively affected, the incidence of anxiety and depression was low, traumatic events were rare, and positive rational acceptance was mostly chosen as the main method of coping with body image negativities in cosmetic patients. Compared with controls, cosmetic patients demonstrated higher reward dependence, empathy, and purposefulness scores, without evidence of increased psychopathology.
WCN26-6583 Oral lactoferrin in anemia of chronic kidney disease: A systematic review and meta-analysis
(Elsevier, 2026) Magal, Abhijith; Arslan, Felemez; Silva, Rafaela Pereira; Bayer, Ekin Şiar; Paiva de Almeida, Vitor
Introduction: Anemia is a prevalent and multifactorial complication of chronic kidney disease (CKD), often driven by inflammation, impaired iron metabolism, and reduced erythropoietin production. Lactoferrin, an iron-binding glycoprotein with immunomodulatory and antimi crobial properties, has demonstrated efficacy in improving iron indices in general iron deficiency anemia. However, its role in CKD-associated anemia remains inadequately characterized. Methods: A systematic review and meta-analysis were conducted to evaluate the effectiveness of oral lactoferrin compared to standard-of care therapies—including iron supplementation and/or erythropoiesis stimulating agents—for the treatment of anemia in adult and pediatric CKD patients. PubMed, Embase, and Cochrane CENTRAL were searched through May 7, 2025. Data were pooled using a random-ef fects model, and heterogeneity was assessed using the I2 statistic. Sensitivity analyses and trial sequential analysis (TSA) were performed to assess robustness and adequacy of cumulative evidence. Results: Four studies comprising 413 participants were included in the final analysis. Lactoferrin supplementation was associated with a statistically significant increase in transferrin saturation (MD: 8.12%; 95% CI: [0.61, 15.63]; p = 0.03), while improvements in hemoglobin (MD: 0.66 g/dL; 95% CI: [-0.06, 1.38]; p = 0.07) and serum iron (MD: 19.20 mcg/dL; 95% CI: [-4.56, 42.96]; p = 0.11) did not reach statistical significance. Conclusion: Oral lactoferrin supplementation was associated with a significant improvement in transferrin saturation and a non-significant trend toward higher hemoglobin and serum iron levels in CKD-related anemia. While these findings suggest a potential role in improving functional iron availability, further well-designed trials are needed to confirm its clinical utility.
Comparison of caudal and retrolaminar blocks for postoperative analgesia in pediatric orchidopexy: A randomized controlled trial
(Edizioni Minerva Medica S.p.A., 2026) Özen, Volkan; Umutoğlu, Tarık; Turan, Engin İhsan; Ayas, Tahir Arda; Yiğit, Doğakan; Çiftçi, Bahadır; Alver, Selçuk
Background: Lower abdominal surgeries in children are associated with significant postoperative pain. While caudal block (CB) is widely used, ultrasound-guided truncal blocks such as retrolaminar block (RLB) may provide more targeted and prolonged analgesia. METHODS: In this double-blind, randomized controlled trial conducted at two tertiary hospitals (March 1-September 1, 2025), children aged 1-7 years (ASA I-II) scheduled for unilateral orchidopexy were randomized to RLB or CB. CB received 0.125% bupivacaine 1 mL/kg (max 20 mL); RLB received 0.25% bupivacaine 0.1 mL/kg, both under standardized general anesthesia with intraoperative IV paracetamol (10 mg/kg). FLACC scores were recorded at 30 min and 1, 2, 4, 6, 12, and 24 h. Rescue analgesia was IV paracetamol for FLACC 2-4 and IV tramadol for FLACC >4. Primary outcome was analgesic efficacy (FLACC at 12th hour). Secondary outcomes were time to first analgesic and total consumption within 24 h. RESULTS: Sixty-two patients were analyzed (N.=31 per group); baseline demographics did not differ. RLB yielded lower FLACC scores at 6 h (P=0.002), 12 h (P=0.007), and 24 h (P=0.018), with no difference at 30 min or 1 h (P>0.05). Time to first analgesic was longer with RLB (P<0.001), and total 24-h consumption was lower (P=0.001). Fewer patients required rescue analgesia with RLB (3/31) than CB (14/31). No major block-related complications occurred. CONCLUSIONS: In pediatric orchidopexy, RLB provided superior and more durable analgesia than CB, reduced 24-h analgesic requirements, and delayed first rescue dosing without major complications, supporting its role within opioid-sparing pediatric ERAS pathways.
Shrinking follow-up duration in pilonidal sinus surgery, 1970–2020: A patient-weighted longitudinal analysis of 2,285 studies
(Springer Nature Link, 2026) Arslan, Çiğdem; Seifert, Jannik; Doll, Dietrich
Background: Reliable estimation of recurrence after pilonidal sinus surgery requires sufficient follow-up (FUP). Despite evidence suggesting ≥5 years is necessary, contemporary reports appear to adopt progressively shorter surveillance windows. Methods: We assembled a structured database of 2,285 pilonidal surgery series (1850–present) and extracted publication mid-decade, FUP since surgery, and cohort size (n). For 1970–2020, we calculated decade-wise patient-weighted mean FUP. Secular change was estimated using weighted least squares (WLS; weights=n), with unweighted sensitivity analyses. Associations between decade and FUP were assessed via weighted Pearson correlation with Kish effective sample size. We summarized proportions meeting ≥2, ≥5, ≥10 years and patient shares by FUP bands. Results: Median FUP was 1.67 years; mean 2.50 years. Only 14.2% of studies reported ≥5 years and 2.9% ≥10 years. Patient-weighted mean FUP peaked in the 1980s at 6.69 years, declining to 5.26 (1990s), 4.26 (2000s), 3.14 (2010s), and 2.55 years (2020s). Relative to the 1970s (3.78 years), the 2020s were −1.23 years (−32.5%), and −4.14 years (−61.9%) below the 1980s. The WLS slope was −0.0766 years·year⁻¹ (95% CI −0.0856 to −0.0675; p=4.57×10⁻⁵⁸); unweighted slope −0.0407 (95% CI −0.0479 to −0.0334; p=1.47×10⁻²⁷). Weighted correlation: Rw=−0.342 (Kish n≈216; p=2.5×10⁻⁷). In the 2020s, patients were distributed as 55.3% <2 years, 26.6% 2–<5, 15.8% 5–<10, 2.3% ≥10. Conclusions: Follow-up windows have contracted substantially, risking under ascertainment of late recurrences. A minimum of ≥5-year FUP with staged reporting at 5 and 10 years and registry-based surveillance is recommended. The absence of a pilonidal core outcome set (COS) in guidelines impedes consistent, long-horizon reporting; COS development and guideline adoption should be prioritized.
Evaluation of changes in oral and dental health and deleterious oral habits after adenoidectomy or adenotonsillectomy in children
(Korean Association of Orthodontists, 2026) Arat Maden, Eda; Yoğurucu Değerli, Gizem; Kurt Dizdar, Senem; Turgut, Suat
Objective: This study aimed to evaluate changes in oral health status and related oral habits in children undergoing adenoidectomy or adenotonsillectomy, focusing on dental indices and mouth breathing-associated symptoms. Methods: This prospective observational study included 52 children (mean age: 7.4 ± 2.1 years) who underwent adenoidectomy or adenotonsillectomy. Clinical evaluations included decayed, missing, and filled teeth for primary dentition/ decayed, missing, and filled teeth for permanent dentition (dmft/DMFT) scores, plaque index (Silness and Löe), gingival index (Löe and Silness), and unstimulated salivary flow rate. Parents completed structured questionnaires assessing their children’s medical and dental history, oral health-related behaviors, and symptoms. Oral health-related quality of life was evaluated using the Early Childhood Oral Health Impact Scale. Results: Statistically significant improvements were found in salivary flow rate (from 0.43 ± 0.21 mL/min to 0.75 ± 0.19 mL/min), plaque index (1.58 ± 0.48 to 1.06 ± 0.33), and gingival index (1.28 ± 0.55 to 0.70 ± 0.39) (all P = 0.001). Several mouth breathing related symptoms, such as snoring, dry mouth, daytime sleepiness, and halitosis, also showed a significant postoperative reduction (P < 0.05). Conclusions: Adenoidectomy or adenotonsillectomy significantly improved periodontal parameters and reduced mouth breathing-associated symptoms in children. These findings highlight the importance of interdisciplinary management involving otolaryngologists, pediatric dentists, and orthodontists.
