İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Epigenetic effects of caffeine on muscle in athletes
(Nutrigenetik Epigenetik Derneği, 2025) Divanoğlu, Ömer; Ercan Karakaya, Zeynep; Mutlu, Hayrettin
Objective: Caffeine is one of the most common ergogenic aids known to increase endurance, strength, and reaction time in athletes. Although its effects are generally thought to be mediated by adenosine receptor antagonism and its stimulatory role in calcium release, recent studies have revealed that caffeine may also influence epigenetic regulatory mechanisms. Epigenetic mechanisms are biochemical processes that alter gene activity without any changes to the DNA sequence, and these processes include DNA methylation, histone acetylation, and microRNA regulation.
Can blastocyst formation rate play a role as a predictor of PGT-A cycle outcomes?
(Elsevier, 2025) Aydın, Gerçek
OBJECTIVE To investigate clinical and embryological parameters that may serve as predictors of pregnancy outcomes in preimplantation genetic testing for aneuploidy (PGT-A) cycles. MATERIALS AND METHODS A total of 98 PGT-A cycles at a private in-vitro fertilization (IVF) center between April 2022 and July 2025 were enrolled. Trophectoderm biopsy cases without any known uterine anomalies and endometrial factor are included. Ovulation induction with letrozole (n=29) or hormone replacement therapy (HRT) (n=69) were used for endometrium preparation. Clinical and embryological cycle characteristics are analysed. Blastocyst formation rate (BFR) was calculated as the number of blastocysts per MII, and the euploidy rate refers to euploid embryos per biopsied embryos. Statistical analysis included t-tests or Mann-Whitney U for continuous variables, and Chi-square test for categorical variables. To identify potential confounding factors subgroup analyses and multivariate logistic regression were performed. RESULTS Among the 98 patients, 62 (63.3%) achieved pregnancy and 36 (36.7%) did not. There were no significant differences between the groups regarding age, BMI, total gonadotropin dose, or stimulation duration. Recombinant FSH agents were the most frequently administered (n=38), followed by hMG (n=23), combination of both (n=15) and recombinant FSH+recombinant LH (n=22). Analyzing the pregnancy results, no statistically significance was observed regarding the agents used, (p>0,05). The BFR was significantly higher in the pregnant group (0.36 ± 0.28) compared to the non-pregnant group (0.27 ± 0.24, p = 0.045). The estradiol/oocyte ratio was slightly higher in the pregnant group (319 ± 180 pg/mL) than in the non-pregnant group (287 ± 148 pg/mL), although not statistically significant (p = 0.48). The euploidy rate per was 59.3% (89/150) in the pregnant group and 68.8% (66/96) in the non-pregnant group, being not statistically significant (p = 0.13). Regarding confounding factors (female or male aneuploidy, the type of gonadotropin, the type of endometrial preparation protocol), none of these demonstrated a statistically significant association with pregnancy outcome in either univariate or multivariate models. CONCLUSIONS Given our results, BFRs may predict pregnancy outcomes whereas euploidy rates do not, despite being higher in non-pregnant cases contrary to expectations. IMPACT STATEMENT BFR in PGT-A cycles may help clinicians both to counsel current patients and to shape more individualized management strategies for future cases.
Nanotechnology approaches in caries management: Insights from a pediatric dentist
(Turkiye Klinikleri Yayınevi, 2025) Esentürk, Gülce; Yoğurucu Değerli, Gizem; Özen, Buğra
This review evaluates the potential contributions of nanotechnology-based materials in caries prevention and management, taking into account the limitations of traditional approaches. Nanomaterials, with their antibacterial, remineralizing, and diagnostic properties, offer an innovative perspective to caries management strategies especially in pediatric dentistry. While the efficacy of dental materials modified with nanotechnology is enhanced, pH-responsive and targeted smart drug carrier systems along with theranostic approaches can optimize the treatment process via minimally invasive methods, thus increasing success rates. These innovative strategies are expected to play a critical role in updating caries management protocols and providing long-term solutions in pediatric dentistry.
Dietary supplement use among amateur bodybuilders in Türkiye: A preliminary report
(Instituto Politécnico de Setúbal, 2025) Arslan, Utku; Sanchez-Oliver, Antonio Jesus; Günalan, Elif
Dietary supplements (DS) are of great interest among bodybuilders today due to their performance-enhancing and muscle development-supporting effects. However, unconscious use of these products can lead to adverse health consequences. Especially among amateur athletes, risk factors increase due to a lack of information, misdirection, and information from unreliable sources. This research aimed to examine the habits of sports supplement usage, frequency of use, preferred types of supplements, and motivation sources for these habits among amateur athletes in Türkiye.
Exploring nutritional supplement use by Turkish handball players: A pilot study
(Instituto Politécnico de Setúbal, 2025) Mor, Ömer; Bayraktar, Bülent; Sanchez-Oliver, Antonio Jesus; Günalan, Elif
Handball is popular with high physical, physiological, and psychological demands. In addition to high-intensity movements, handball players must have performance components such as strength, agility, and speed and a suitable aerobic form to cope with high-intensity efforts. An optimal nutrition strategy helps maintain physical and cognitive performance, supports injury prevention, return to play, training adaptations, accelerates, and optimizes recovery processes. It has been stated in the literature that handball players tend to use nutritional supplements (NS) to facilitate the achievement of their nutritional goals. Therefore, studying how handball athletes use NS can offer an important understanding of the factors influencing their success. This study investigates supplement use among Turkish handball players and assessing the factors that shape their supplementation practices.
