İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Boric acid mitigates alcohol-induced renal podocyte injury, apoptosis, and oxidative stress in HBV transgenic mice
(MDPI Publishing, 2026) Şevgin, Kübra; Ergüven, Pelin; Tanrıkulu Küçük, Sevda; Değirmencioğlu, Sevgin; Çetinalp, Pınar; Aksu, Soner; Gün Atak, Palmet; Söğüt, İbrahim
Chronic alcohol consumption exacerbates kidney injury, particularly in individuals with hepatitis B virus (HBV) infection. This study investigated the protective effects of boric acid supplementation against alcohol-induced renal damage in HBV transgenic mice. HBV transgenic mice were divided into four groups: control (C), boric acid (B), alcohol (A), and alcohol + boric acid (A + B). Renal injury was evaluated using H&E, PAS, TUNEL, and desmin staining. The expression of caspase-3, cytochrome c, and APAF-1 was analyzed by qRT-PCR. Biochemical analyses included BUN, creatinine, oxidative stress markers (ROS, MDA, TOS, OSI), total antioxidant status, and antioxidant enzyme activities (SOD, CAT, GPx). Histopathological findings showed activated parietal epithelial cells in all groups, indicating renal injury. Alcohol significantly increased tubular damage, podocyte desmin expression, apoptosis, cytochrome c and APAF-1 mRNA levels, and oxidative stress markers, while reducing antioxidant enzyme activities and BUN levels compared with controls. Boric acid supplementation significantly mitigated alcohol-induced tubular injury, apoptosis, oxidative stress, and serum creatinine levels, and improved BUN values. Boric acid treatment alone also alleviated glomerular and tubular injury and reduced tubular apoptosis compared with HBV control mice. Overall, boric acid exerts renoprotective effects in HBV-transgenic mice subjected to chronic alcohol exposure by inhibiting oxidative stress, apoptosis, and podocyte injury.
Beyond organ-specific therapies: A unified approach to multi-organ fibrosis
(Dove Medical Press Ltd, 2026) Pan, Ziyan; Zerehpoosh, Shadi; Wang, Shu-Chi; Örmeci, Necati; Kim, Won; Eslam, Mohammed
Organ fibrosis, characterized by excessive scarring of tissues in the liver, kidney, lung, and heart, poses a significant and growing global health challenge, resulting in considerable morbidity and mortality, with a lack of effective treatment options. Most research and drug development efforts have traditionally focused on individual organs in isolation. This review aims to provide a comprehensive perspective on multi-organ fibrosis, highlighting recent advances that clarify the complex cellular and molecular mechanisms involved in the liver, kidney, lung, and heart. It examines both common and organ-specific factors that drive fibrogenesis. Additionally, the review discusses the current and future landscape of antifibrotic therapies, including innovative approaches to developing pan-organ antifibrotic drugs. Challenges and future directions in the design of clinical trials are also addressed.
CuSn(OH)6 nanoparticles as a novel adsorbent for the preconcentration of cadmium ions in onion extract
(Springer Nature Link, 2026) Şaylan, Meltem; Gürsoy, Selim; Polat Korkunç, Ümmügülsüm; Zaman, Buse Tuğba; Bakırdere, Sezgin
The present study aims to develop a new preconcentration strategy for the determination of non-essential cadmium ions in red onion samples. Determination of the extracted cadmium ions was carried out using flame atomic absorption spectrom etry for efficient and sensitive detection. The synthe sis of CuSn(OH)6 nanoparticles was accomplished via a single-step one-pot coprecipitation method under ambient conditions to obtain nanoparticles below 100 nm in size, which are particularly effec tive for preconcentration procedures. The morphol ogy and structure of the nanoparticles were confirmed with different characterization techniques. Under the optimized conditions, the calibration curve of the presented method showed good linearity between 2.5 and 50 μg/L, with a detection limit of 0.84 μg/L. The accuracy of this method was confirmed by obtaining recoveries of spiked red onion extracts. This method offers a sensitive, efficient, and eco-friendly method for the separation/detection of trace cadmium ions in aqueous plant-derived matrixes, especially red onion extracts.
Exoclock project. IV. A homogeneous catalog of 620 updated exoplanet ephemerides
(American Astronomical Society, 2026) Kokori, A.; Tsiaras, A.; Pantelidou, G.; Jones, A.; Siakas, A.; Edwards, B.; Tinetti, G.; Wünsche, A.; Solmaz, Arif; Libotte, F.
The ExoClock project is an open platform aiming to monitor exoplanets by integrating observations from space- and ground-based telescopes. This study presents an updated catalog of 620 exoplanet ephemerides, integrating 30,000 measurements from ground-based telescopes (the ExoClock network), literature, and space telescopes (Kepler, K2 and TESS). The updated catalog includes 277 planets from TESS which require special observing strategies due to their shallow transits or bright host stars. This study demonstrates that data from larger telescopes, and the employment of new methodologies such as synchronous observations with small telescopes, are capable of monitoring special cases of planets. The new ephemerides show that 45% of the planets required an update while the results show an improvement of 1 order of magnitude in prediction uncertainty. The collective analysis also enabled the identification of new planets showing transit-timing variations, highlighting the importance of extensive observing coverage. Developed in the context of the ESA’s Ariel space mission, with the goal of delivering a catalog with reliable ephemerides to increase the mission efficiency, ExoClock’s scope and service have grown well beyond the remit of Ariel. The ExoClock project has been operating in the framework of open science, and all tools and products are accessible to everyone within academia and beyond, to support efficient scheduling of future exoplanet observations, especially from larger telescopes where the pressure for time allocation efficiency is higher (Ariel, JWST, VLT, ELT, Subaru etc.). The inclusion of diverse audiences in the process and the collaborative mode not only foster democratization of science but also enhance the quality of the results.
APASL clinical practice guidelines on the management of chronic hepatitis b infection: A 2026 update
(Asian Pacific Association for the Study of the Liver (APASL), 2026) You, Hong; Maiwall, Rakhi; Chen, Jing; Ahn, Sang Hoon; Dökmeci, Abdul Kadir; Dou, Xiaoguang; El-Sayed, Manal; Fan, Jian-Gao; Örmeci, Necati; Gao, Zhiliang
Globally, especially in the Asia-Pacific region, chronic hepatitis B infection has led to an undesirable escalating morbidity and mortality with acute-on chronic liver failure, end-staged liver cirrhosis and hepatocellular carcinoma. This has happened despite the past four-decades of major scientific advances made in screening methods, vaccination strategies, highly effective low-cost anti-viral therapies and surveillance strategies for early detection of hepatocellular carcinoma. To address this health threat, APASL has formed a Viral Elimination Taskforce to unite key opinion leaders from its member countries and regions. The ongoing shifts in hepatitis B epidemiology, socioeconomic changes, and advancements in technology are taken into consideration. With the conjoint efforts of all the members of the APASL Viral Elimination Taskforce, this clinical practice guidelines have been formulated aiming to facilitate healthcare professionals, policy makers and patients in making practical and cost-effective management decisions for chronic hepatitis B infection. Altogether, it provides recommendations in thirteen major areas related to screening, vaccination, treatment and HCC surveillance. The implementation of this clinical practice guidelines represents major APASL effort toward elimination of the disease burden due to chronic hepatitis B infection in Asia-Pacific region.
