İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Dynamics of the forced thirring instanton with two forcing terms
(Springer Nature Link, 2025) Ak, Mine
We consider the dynamical behavior of fermionic instanton solutions of the Thirring Model with two forcing terms. In particular, the study focuses on the effect of the frequency and amplitude of the forcing terms on the behavior of fermionic instan ton solutions. Numerical analysis based on the Smaller Alignment Index (SALI) method, Bifurcation Diagram and Permutation Entropy (PE) are used to show how and which dynamical behaviors occur in the system. Color maps and diagrams of the SALI time (St ) (the time St required for the SALI index to below a threshold value of 10−12) and PE of the system with respect to varying of frequency and amplitude values of the forcing terms are plotted comparatively to determine dif ferent dynamical behavior of the system. The study shows that fermionic instanton solutions exhibit a wide variety of dynamical behavior due to two forcing terms. Furthermore, it is emphasized that SALI time (St ) can be easily compared with bi furcation diagram and complexity method as a fast, efficient and precise method to investigate different degrees of chaos. In general, the instanton solutions with two forcing terms have been observed to exhibit different type of dynamical behavior. In this study, identical and symmetric coexisting attractors are demonstrated for these different types of behavior of the forced Thirring instanton.
Çobanoğlu çekme helva işletmesi
(Gazi Kitabevi, 2025) Şensoy, Necdet; Şensoy, Fatma; Durmuş, Ahmet Fethi; İnanç, Rıdvan; Çemberlitaş, İbrahim; Yücel, Göksel; Kurt, Ganite; Adiloğlu, Burcu
Çobanoğlu Çekme Helva işletmesi, Kastamonu'nun geleneksel gıda üretiminde öne çıkan örneklerinden biridir. 1994 yılında Coşkun Çobanoğlu tarafından kurulan işletme, başlangıçta küçük ölçekli bir üretim tesisi olarak faaliyet göstermiştir. Kuruluş sürecinde sınırlı sermaye ve yoğun emek gücü ile üretim yapılırken, zamanla teknolojik gelişmelerin de etkisiyle makineleşmeye geçilmiştir. İşletme sahibi, görüşme sırasında özellikle 1994 sonrasında üretimde modern makinelerin kullanılmaya başlandığını ve bugün üretimin yaklaşık %60'ının makine destekli gerçekleştiğini, geri kalanının ise geleneksel yöntemlerle sürdürüldüğünü ifade etmiştir. Bu durum, işletmenin hem modern üretim kapasitesine ulaşmasını hem de geleneksel tat ve kalitenin korunmasını sağlamaktadır.
Elimination of hepatitis c in Turkey
(IntechOpen, 2025) Örmeci, Necati; Musabaev, Erkin Isakovich
This manuscript examines the epidemiological patterns, transmission routes, and genotypic distribution of hepatitis C virus (HCV) in Türkiye, highlighting national progress toward elimination targets set by the World Health Organization (WHO). The main objective is to evaluate the effectiveness of national screening, diagnostic, and treatment strategies, with a focus on the scale-up of direct-acting antiviral (DAA) therapies and their associated cost-effectiveness. Drawing on recent multicenter and population-based studies, the paper outlines the shifting prevalence of HCV geno types, particularly among high-risk populations such as people who inject drugs (PWID), prisoners, and individuals undergoing hemodialysis. The analysis demon strates that genotype 1b remains predominant, though genotype diversity is increas ing due to migration and changing transmission dynamics. Findings reveal that despite improved availability of DAA treatments and health policy initiatives like the 2018–2023 National Viral Hepatitis Program, gaps persist in diagnostic follow-up and referral. The manuscript emphasizes the dual approach of micro- and macro elimination, advocating for integrated care models, increased physician engagement, and enhanced awareness efforts. Projections suggest that achieving WHO goals is feasible in Türkiye if testing and treatment rates significantly improve. Ultimately, this study underscores the necessity of sustained political commitment, intersectoral collaboration, and targeted public-health interventions to reduce HCV-related mor bidity and mortality by 2030.
A high geometric albedo and small size for the haumea cluster member (24835) 1995 SM55 determined from a stellar occultation and photometric observations
(EDP Sciences, 2025) Ortiz, Jose L.; Morales Palomino, Nicolas F.; Sicardy, Bruno; Rommel, Flavia Luane; Braga Ribas, Felipe; Kılıç, Yücel; Fernández-Valenzuela, Estela; Rizos García, Juan Luis; Solmaz, Arif; Morgado, Bruno
Context. Trans-Neptunian objects (TNOs) are thought to be some of the most ancient and primitive bodies in our Solar System. Understanding their basic physical properties is crucial to unraveling their origin and the evolution of the outer Solar System beyond Neptune. Stellar occultations are a highly effective and sensitive method of studying these distant and faint objects, allowing us to gather essential information about their physical characteristics. (24835) 1995 SM55 is one of the few members of the Haumea orbital cluster and, therefore, is an especially relevant body to study within the TNO population. Aims. The main objectives of the present work are to determine the projected size, absolute magnitude, and geometric albedo of 1995 SM55 and to analyze the results compared to Haumea. Methods. We predicted a stellar occultation by this TNO for February, 25, 2024, carried out a specific campaign to observe the occultation, and derived the projected size and shape from the occultation observations using an elliptical fit to the occultation chords. We also analyzed a large set of photometric observations of (24835) 1995 SM55 to obtain the absolute magnitude and the rotational period. Finally, we combined these results to derive the geometric albedo of this TNO. Results. The occultation was successfully detected from seven instruments located at five different sites; 33 other sites reported negative detections. Using an elliptical fit to the occultation chords, we determined the size and shape of the limb of (24835) 1995 SM55 during the occultation: an ellipse with semi-axes (104.3 ± 0.4) × (83.5 ± 0.5) km. The area-equivalent diameter (Deq,A) for this ellipse is 186.7 ± 1.8 km. This is consistent with the upper limit of 250 km estimated from Herschel Observatory thermal data. From our photometric observations, we derived an absolute magnitude (HV ) of 4.55 ± 0.03, a phase slope parameter of 0.04 ± 0.02 mag/deg, and a V − R value of 0.37 ± 0.05. The rotational variability has a maximum peak-to-valley amplitude (∆m) of 0.05 mag, but we could not derive an unambiguous rotational period. Combining the projected size from the occultation with the absolute photometry, we obtained a geometric albedo in the V band (pV ) of 0.80 ± 0.04 for 1995 SM55. This value is remarkably high for a TNO and somewhat higher than that of Haumea, but consistent with the concept that 1995 SM55 is a member of the orbital cluster of Haumea.
Hereditary breast, ovarian, pancreatic and prostate cancer syndrome: Multigene testing, multiomics, and risk management
(Türk Radyasyon Onkolojisi Derneği, 2025) Dinç, Ahmet; Yazıcı, Hilal; Yazıcı, Hülya
Hereditary breast, ovarian, pancreas and prostate cancer (HBOC/HBOPC) syndromes remain a major global health concern, with BRCA1, BRCA2 and other high- or moderate-risk homologous recombi nation repair (HRR) gene variants driving a significant share of familial cancer risk. Beyond breast and ovarian sites, these mutations increase susceptibility to prostate, pancreatic, and other solid tumors, high lighting the syndromic nature of HBOPC. Advances in multigene panel testing (MPT), AI-supported variant classification, and polygenic risk scores (PRS) now enable more precise risk estimation, while functional reclassification and population-specific founder mutation mapping reduce uncertainty in un derrepresented groups. Emerging epigenetic and non-coding RNA biomarkers further strengthen early detection and treatment stratification. However, large-scale validation is still needed to translate these tools into equitable care. Risk-reducing surgeries, tailored surveillance, and targeted therapies—includ ing PARP inhibitors, immunotherapy, and homologous recombination deficiency (HRD)-based regi mens—have transformed management but require equitable access and culturally sensitive counseling to address psychosocial barriers and family communication challenges. Real-world data (RWD) and cross border variant databases are essential to bridge gaps between guidelines and practice, especially where founder effects and mosaicism complicate standard criteria. This review integrates current evidence on the genetic and molecular foundations, organ-specific management, evolving therapies, and ethical di mensions of HBOPC care. By combining multidisciplinary insights with AI, functional analyses, and real-world implementation strategies, this review highlights how next-generation precision oncology can deliver equitable, high-quality, and locally adapted prevention and treatment for families worldwide.
