İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Therapeutic potential of alpha‑tocopherol in reducing oxidative stress and inflammatory damage after experimental traumatic brain injury and pentylenetetrazol‑induced seizures
(Springer Nature Link, 2026) Demirtaş, Cumaali; Yıldırım, Hava; Demir, Hüseyin; Kıroğlu, Sezin; Şevgin, Kübra; Beyaztaş, Hakan; Güler, Eray Metin; Hekimoğlu, Gulam; Aykın, Uğur; Coşkunpınar, Ender Mehmet; Yıldırım, Mehmet
The effects of alpha-tocopherol on seizure parameters, locomotor-cognitive functions, inflammatory response, oxidative stress response, histopathological changes, immunohistochemical parameters, and miRNA fold changes were investigated in rats with traumatic brain injury (TBI) and pentylenetetrazol (PTZ)-induced seizures. Sprague–Dawley male rats were randomly divided into three groups: Control (n = 8), TBI + PTZ (n = 10), and TBI + PTZ + tocopherol (n = 10). After inducing TBI in animals using the weight-drop method, increased post-injury seizure susceptibility was achieved by administering subconvulsive doses of PTZ. Saline was administered intraperitoneally to the control and TBI + PTZ groups for 6 days, while 500 mg/kg alpha-tocopherol was administered intraperitoneally to the TBI + PTZ + tocopherol group. Seizure intensity, sei zure frequency, and total seizure duration were significantly reduced in the TBI + PTZ + tocopherol group compared to the TBI + PTZ group (p < 0.05). No significant adverse effects related to TBI and PTZ were observed in the animals’ locomotor activity, anxiety-like behaviors, or learning and memory test outcomes. In the TBI + PTZ + tocopherol group, significant reductions were observed in inflammatory cytokine response, oxidative stress, and SUR1-TRPM4 channel activity compared to the TBI + PTZ group (p < 0.001). While degenerative and apoptotic neurons and the number of 8-OHdG-positive cells in the CA1 and dentate gyrus regions were limited in the TBI + PTZ + tocopherol group, downregulated miR-324-5p increased (p < 0.05). Alpha-tocopherol reduced the severity and duration of seizures, reduced oxidative stress and inflammation, and stabilized the thiol-disulfide balance. It also reduced degenerative cell structures and DNA damage in the cortex, hippocam pus, and dentate gyrus. In conclusion, the findings of this study suggest that alpha-tocopherol is a potential neuroprotective agent that modulates early epileptogenic network instability in TBI and seizure susceptibility through multiple pathways, including oxidative stress, inflammation, and ion channel regulation.
Large-scale airline ticket price prediction using ensemble machine learning algorithms
(Şerafettin Sevgili, 2025) Ertürk, Muzaffer; Emeç, Murat; Atılgan Sarıdoğan, Ayşe; Küçükgergerli, Nabi
Airline ticket price prediction represents a highly complex and dynamic challenge, primarily due to the multifactorial and time-sensitive nature of airline pricing strategies. Accurate forecasting of ticket prices holds substantial value for both consumers, by enabling optimal purchase decisions, and airline companies, by supporting data-driven revenue management and dynamic pricing. In this study, we conduct a comprehensive analysis of a large-scale flight booking dataset obtained from the “Ease My Trip” platform, encompassing over 300,000 records of flight options between major Indian metropolitan cities. A suite of advanced machine learning algorithms, including Linear Regression, CatBoost, LightGBM, Random Forest, and XGBoost, was implemented to model and predict ticket prices. A comparative evaluation of these models reveals that ensemble and boosting algorithms, particularly XGBoost and Random Forest, deliver superior predictive performance, with XGBoost achieving an R² of 0.98 and a mean absolute error (MAE) of $2,035.51. These findings underscore the critical importance of employing robust machine learning techniques and incorporating a diverse set of features for reliable airline ticket price prediction. The results offer valuable insights for both passengers seeking cost-effective travel and airline stakeholders aiming to optimise revenue management strategies.
Corrugator supercilii muscle and its relationship with neurovascular structures of the frontal region: A cadaveric study
(Springer Nature Link, 2026) Yıldız, Nilay; Nteli Chatzioglou, Gkionoul; Coşkun, Osman; Kale, Ayşin; Gayretli, Özcan
Background The corrugator supercilii muscle (CSM) is a critical anatomical target for botulinum toxin injections and surgical interventions in migraine treatment and facial rejuvenation. However, complications such as sensory loss or vascular injury may arise due to its proximity to neurovascular structures. This study aims to delineate the precise anatomy of the CSM and its relationship with the supratrochlear (STN) and supraorbital nerves (SON) to enhance procedural safety. Methods A cadaveric dissection was performed on 44 hemifaces of 22 formalin-fixed cadavers (11 male and 11 female). The CSM and adjacent neurovascular structures were dissected, photographed, and measured using ImageJ software. Morphometric parameters included distances related to the CSM, as well as branching patterns of the STN and SON were evaluated. Results The CSM length was significantly longer in females (30.53 ± 2.60 mm; 28.93 ± 2.15 mm, p = 0.032). The STN exhibited complex branching (> 3 branches) in 48% of cases, with 13.6% piercing the CSM anteriorly. The SON medial branch pierced the CSM’s lateral segments (46.5% 3rd segment; 53.5% 2nd segment). The supratrochlear artery crossed the CSM 14.84 ± 2.05 mm (females) and 15.43 ± 2.04 mm (males) from the midline, while the supraorbital artery lay 25.38 ± 3.76 mm (females) and 24.49 ± 4.55 mm (males) lateral to the midline. Conclusions The CSM’s intimate relationship with the STN, SON, and associated vessels underscores the risk of iatrogenic injury during forehead procedures. Anatomical variations in nerve branching and muscle morphology highlight the need for individualized approaches to botulinum toxin injection and surgical resection. These findings may reduce complications and improve outcomes in migraine surgery and aesthetic interventions. No Level Assigned This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
PEGDA-based nanocomposite gel polymer electrolytes with hydroxylated h-BN nanosheets enabling fast ion transport and high-voltage stability for lithium metal batteries
(Springer Nature Link, 2026) Yaman Uzunoğlu, Gülşah
Despite their favorable interfacial contact and high ionic conductivity, gel polymer electrolytes (GPEs) remain constrained by insufficient electrochemical and thermal/mechanical stability as well as low lithium-ion transference numbers, restricting their long-term application in lithium metal batteries (LMBs). In this study, a poly(ethylene glycol) diacrylate (PEGDA) based nanocomposite gel polymer electrolyte (NGPE-BN-x) was developed by thermal in situ polymerization, incorpo rating a few-layer hydroxylated hexagonal boron nitride nanosheets (h-BNNS-OH) as a two-dimensional (2D) nanofiller. The influence of h-BNNS-OH loading (1, 3, and 5 wt%) on lithium ion transference number (tLi +), ionic conductivity, electrochemical, thermal and mechanical stability was systematically evaluated relative to the pristine GPE. The optimized NGPE-BN-3 exhibited high ionic conductivity (σ = 8.85 mS cm− 1), an expanded electrochemical stability window (ESW) of 5.01 V, an enhanced tLi + of 0.66, and improved mechanical strength (0.64 MPa) at room temperature. LFP//Li full cells utilizing NGPE-BN-3 yielded a discharge capacity of 162.2 mAh g− 1 at 0.1 C with good rate capability (0.1-2.0 C), and prolonged cycling stability at 1 C under ambient conditions. The improved electrochemical performance highlights the effectiveness of h-BNNS-OH as a multifunctional additive for PEGDA-based GPEs toward high-performance LMBs.
A natural solvent-based gel electrolyte for stable and sustainable zinc-ion batteries
(Wiley, 2026) Kömürcüoğlu, Gökçe; Adhami, Sadaf; Yaman Uzunoğlu, Gülşah; Yüksel, Recep
Natural solvent-based electrolytes are increasingly sought for zinc-ion batteries (ZIBs) as they provide a sustainable and cost-effective means to regulate water activity and electrode–electrolyte interfacial chemistry while retaining the intrinsic safety of aqueous systems. Herein, a sustainable electrolyte formulation utilizing a chia seed (CS)-based hydrogel is reported as an effective approach to improve the electrochemical stability of ZIBs. Owing to its high content of hydroxyl-rich polysaccharides and phenolic compounds, the chia seed-derived gel electrolyte (CSGE) tailors the Zn2+ solvation environment, decreases free-water activity, and restrains parasitic hydrogen evolution as well as dendritic zinc growth. Benefiting from this regulated solvation environment, the CSGE achieved a remarkably high Zn2+ transference number of 0.84. Consequently, Zn//Zn symmetric cells demonstrated outstanding electrochemical stability exceeding 4000 h at 1.0 mA cm−2 and 1.0 mAh cm−2. Moreover, Zn//V2O5 cells achieved a high discharge capacity of 337.8 mAh g−1 at 0.1 A g−1 and maintained reliable rate performance between 0.2 and 10 A g−1. In addition, ex situ SEM and XRD analyses revealed homogeneous deposition of Zn with a preferred (002) orientation. These findings demonstrate that electrolytes derived from renewable resources provide a cost-effective route for stable and sustainable ZIBs.
