İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Redox-responsive and mucoadhesive nanoparticles: An overlooked synergy in modern drug delivery
(Elsevier, 2026) Küçükertuğrul Çelik, Sibel; Şentürk, Sema; Bal, Kevser; Kaplan, Özlem; Gök, Mehmet Koray
The continuous advancement of therapeutic technologies has intensified the pursuit of drug delivery systems that respond intelligently to physiological and pathological stimuli, thereby enabling precise, localized, and sustained therapeutic outcomes. Among redox-based approaches, systems responsive to intracellular glutathione (GSH) have attracted particular attention due to their ability to trigger disulfide bond cleavage and controlled release within diseased tissues. Mucoadhesive systems, on the other hand, prolong residence time on mucosal surfaces through non-covalent interactions and covalent bond formation, thereby facilitating increased absorption and decreased clearance. Despite their individual successes, the integration of these two mechanisms remains underexplored. This review critically examines the coupling of redox sensitivity and mucoadhesion, highlighting how disulfide-based bonds can simultaneously function as both redox-cleavable and mucoadhesive moieties.
Holmium/thulium laser enucleation of the prostate
(Springer, 2026) Açıkgöz, Onur; Yılmaz, Mehmet; Kaya, Engin; Tonyalı, Şenol; Liatsikos, Evangelos N.; Seçkiner, İlker; Kadıoğlu, Ateş
With the introduction of lasers into endourological practice, there has been a major paradigm shift in terms of urological interventions. Especially in the last 10 years, Holmium laser enucleation followed by Thulium laser enucleation of the prostate has become increasingly popular in the surgical treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). With low perioperative complication rates and successful postoperative outcomes, laser enucleation of the prostate (LEP) is now a globally accepted surgical approach for the surgical treatment of LUTS due to BPH. The aim of this chapter is to provide an overview of laser enucleation of the prostate; including operating theatre preparation prior to LEP, different surgical techniques, details of the learning curve, and postoperative complications.
A randomized controlled trial of internet-based cognitive behavioral therapy (iCBT) and EMDR-flash technique (iEMDR-FT) for improving mental health in breast cancer patients
(Springer Nature Link, 2025) Savaş, Esra; Gündoğmuş, İbrahim; Kınık, Çiğdem; Kubilay, Derin; Kavakçı, Önder; Yaşar, Alişan Burak
This study aims to compare the effectiveness of internet-based Cognitive Behavioral Therapy (iCBT) and internet-based Eye Movement Desensitization and Reprocessing (EMDR) Flash Technique (iEMDR-FT) in reducing fear of cancer recur rence, traumatic stress, anxiety, depression, and increasing the quality of life among patients diagnosed with breast cancer. A randomized controlled trial was conducted with a sample of patients, equally divided into two treatment groups. The iCBT program was administered over 7 weeks, while the iEMDR-FT was delivered in three sessions in three days. The participants were given a sociodemographic data form, Posttraumatic Stress Disorder Control List DSM-5 (PCL-5), Fear of Cancer Recurrence Scale, Depression-Anxiety-Stress 21 scale (DASS-21), and World Health Organization Quality of Life Scale Short Form. Participants were assessed before, immediately after, and three months post-intervention. The mean age of the participants was 43.79 (7.45) years. In comparing the two groups, a statistical difference was found only in the age variable (p=0.025). As a result, there was no significant difference between the two groups when sociodemographic and cancer-related ratings were compared (p>0.05). It was determined that the change in iEMDR-FT scores in all scales was not statistically significantly different compared to the iCBT group (p>0.05). Initial analysis indicates that both iCBT and iEMDR-FT resulted in notable decreases in traumatic stress, fear of cancer recurrence, anxiety, and depression among breast cancer patients. However, this therapeutic improvement is similar in both applications. This result supports the argu ment that two methods with similar effectiveness can be used as alternatives to each other in treatment.
Numerical investigation of a savonius wind turbine with different blade overlap distances
(IWEC, 2025) Kırlı, Ahmet Özkan; Gürel, Barış; Özdemir, Kadir
This study examines the aerodynamic efficiency of a Savonius-type vertical-axis wind turbine with various blade gap configurations at different wind speeds through numerical methods. Blade gaps of 10 mm and 20 mm were examined at constant inlet wind velocities of 3, 7, and 11 m/s using two-dimensional transient Computational Fluid Dynamics (CFD) models. The numerical studies utilised the standard k–ε turbulence model to minimise computational expenses, employing a time step of 0.002 seconds across a total simulation period of 15 seconds. The findings indicate that the 10 mm blade gap consistently surpasses the 20 mm arrangement across all wind speed conditions. The findings demonstrate that a diminished blade gap markedly enhances flow organisation, torque stability, and energy conversion efficiency, underscoring the promise of optimised Savonius rotor geometries for small-scale and low-wind renewable energy applications.
Use of antidote in poisonings due to xenobiotics taken via inhalation route
(Türkiye Klinikleri Yayınevi, 2025) Gökdağ, Eren; Yılmaz Şahin, Nurdan; Yıldırım, Cuma; Sabak, Mustafa
Industrialization, pesticides, and widespread chemical use have increased the risk of inhalational poisonings. These exposures can cause severe respiratory and systemic effects, yet specific antidotes are not available for all agents. Where available, timely administration of antidotes can be lifesaving. The article reviews antidotes employed in poisonings resulting from inhaled toxic substances, with a focus on their pharmaceutical structures, clinical applications, and adverse effects. Atropine and pralidoxime are used for nerve agents and organophosphate/carbamate poisonings; hydroxocobalamin, sodium nitrite, and thiosulfate for cyanide exposure; naloxone for opioid aerosols; and chelating agents (DMSA, DMPS, BAL, CaNa₂EDTA) for mercury and lead vapors. Conversely, no specific antidote exists for agents such as ammonia, ozone, formaldehyde, methane, and anesthetic gases.
