İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Radiographic evaluation of primary molars treated with the hall technique: A retrospective study
(İstanbul Sağlık ve Teknoloji Üniversitesi, Lisansüstü Eğitim Enstitüsü, 2025) Nezhat Çakar, Maryam; Altun, Ceyhan; Güven Polat, Günseli
Objective: This study aimed to evaluate the radiographic success of the Hall Technique (HT) in the treatment of carious lesions in primary molars of pediatric patients aged 3 10 years. Traditional dental treatments often pose challenges due to anxiety and limited cooperation in younger children, leading modern pediatric dentistry to favor minimally invasive and child-friendly approaches. The Hall Technique offers a biological and practical solution to this need by applying stainless steel crowns directly to the tooth without requiring local anesthesia or caries removal. Materials and Methods: Within the scope of this retrospective study, 151 primary molars from 100 pediatric patients who visited Boğaziçi Dental Clinic between January 2019 and June 2023 were evaluated. These teeth were treated using the HT and followed up radiographically at 6, 12, and 24 months. The evaluation criteria included root resorption, interdental bone loss, periodontal ligament (PDL) widening, and deviations in physiological exfoliation timing. All radiographic images were obtained using the same device, interpreted by a single clinician, and analyzed statistically using SPSS 22 software. Results: The findings indicated that the root resorption rate increased from 1.3% at 6 months to 6.6% at 24 months. Interdental bone loss similarly rose from 0.7% to 11.9% within the same timeframe. However, these increases largely remained within physiological limits and did not result in clinically significant complications. Notably, no instances of PDL widening were observed during any follow-up period, supporting the biological safety of the HT on surrounding tissues. Conclusion: Although some statistical differences were observed in subgroups based on gender, age group, and tooth number, these did not significantly affect the overall success of the treatment. This suggests that HT can be effectively applied across different patient demographics and anatomical variations in primary molars. In conclusion, the Hall Technique demonstrated high radiographic success during the follow-up period, and its minimally invasive nature, ease of application, and compatibility with pediatric patient cooperation position it as a reliable method for caries management in primary teeth. Furthermore, considering its low cost, brief procedure time, and no need for anesthesia, HT presents substantial advantages for public health interventions. The findings of this study align with existing literature and reaffirm the medium-term biological compatibility and clinical effectiveness of the Hall Technique.
The effect of the dash diet on treatment in adult patients diagnosed with rheumatoid arthritis
(İstanbul Sağlık ve Teknoloji Üniversitesi, Lisansüstü Eğitim Enstitüsü, 2026) Özüpek, Gökçen; Altay, İkbal Süheyla; Kalyoncu Atasoy, Zeynep Begüm
This study was designed and conducted to investigate the effect of the Dietary Approaches to Stop Hypertension (DASH) diet on treatment outcomes in patients diagnosed with seropositive rheumatoid arthritis (RA). Participants in the study were randomly selected from volunteers at the Rheumatology Outpatient Clinic at Istanbul Prof. Dr. Cemil Taşcıoğlu City Hospital and Başakşehir Çam and Sakura City Hospital. The cases were allocated into two groups: an intervention group (n=24) and a control group (n=25). In this randomized controlled trial, the DASH diet model administered to the intervention group was planned according to 24-hour physical activity level (PAL) and basal metabolic rate (BMR) and was applied for three months (12 weeks). Participants in the control group did not receive any specific dietary intervention and continued their usual dietary habits. Demographic characteristics, health status, dietary habits, functional status in daily life, quality of life, food frequency, and three-day dietary intake records of the participants were collected via questionnaires. Quantitative data, including PAL, Disease Activity Score-28 (DAS-28), visual analog scale (VAS) general health, VAS pain score, anthropometric measurements, BMR, and DASH diet score, were recorded numerically. Biochemical parameters were obtained from the hospital information system with the approval of the attending physician. During the study, data were re-collected at weeks 4, 8, and 12 for both groups, and statistical analyses were performed using IBM SPSS Statistics 27. The study was completed with a total of 49 participants, of whom 81,6% were female and 18,4% were male. The mean age of participants was 51,67±10,29 years, and they had received pharmacological treatment for RA for an average of 8,36±7,25 years. Between-group analysis revealed that the DASH diet score in the intervention group was significantly higher than that of the control group at weeks 4, 8, and 12, with increased consumption frequency of DASH-specific healthy food groups (p<0,05). Hematological evaluation showed that erythrocyte sedimentation rate (ESR), an acute-phase reactant, was significantly reduced in the intervention group at weeks 4 and 12 compared to the control group (p<0,05). Similarly, in the intervention group, a statistically significant reduction was observed in DAS-28 ESR scores at weeks 4, 8, and 12; in DAS-28 CRP scores, tender joint count, and VAS global health scores at weeks 8 and 12; and in VAS pain scores at week 12 compared to the control group (p<0,05). Within the intervention group, significant enhancements in functional capacity and various quality of life subparameters were observed over time. These effects were particularly pronounced at week 12 compared to the baseline (p<0,05). Notably, concomitant with the increase in the DASH diet score at week 12, significant improvements were observed in patients' VAS global health and VAS pain scores (p<0,05). These findings suggest that the DASH diet model may exert a beneficial effect on treatment outcomes in patients with RA by suppressing inflammation. In this context, the conduct of future scientific studies incorporating long-term follow-up is of great importance in order to elucidate the sustained effects of dietary intervention.
Hemodynamic and clinical effects of the levonorgestrel-releasing intrauterine system in symptomatic adenomyosis: A prospective doppler ultrasound study
(Elsevier, 2026) Şahin, Eda Adeviye; Şahin, Turan; Şahin, Hanifi; Küçüközkan, Tuncay
Objectifs : Évaluer les résultats cliniques, biologiques et les modifications hémodynamiques utérines après la pose d’un système intra-utérin au lévonorgestrel (SIU-LNG) chez des femmes atteintes d’adénomyose symptomatique associée à des saignements menstruels abondants. Méthodes : Cette étude prospective observationnelle a inclus des femmes préménopausées âgées de ≥30 ans présentant une adénomyose diagnostiquée par échographie transvaginale selon des critères échographiques reconnus compatibles avec les descripteurs ultérieurement formalisés dans le consensus MUSA révisé. Les pertes menstruelles évaluées par le Pictorial Blood Loss Assessment Chart (PBAC), la douleur évaluée par échelle visuelle analogique (EVA), les paramètres hématologiques, le volume utérin ainsi que les indices Doppler des artères utérines — indice de résistance (IR) et indice de pulsatilité (IP) — ont été évalués avant la pose du SIU-LNG et après 12 mois de suivi. Les comparaisons avant/après traitement ont été réalisées à l’aide de tests statistiques appariés. Résultats : Soixante-cinq patientes ont complété le suivi à 12 mois. Les scores PBAC ont significativement diminué (169,6 ± 49,6 vs 42,4 ± 20,6 ; p < 0,001), de même que les scores EVA (4,2 ± 1,8 vs 2,4 ± 0,8 ; p < 0,001). Les taux d’hémoglobine et d’hématocrite ont augmenté significativement (p < 0,001). Une réduction significative du volume utérin a été observée (161,3 ± 33,5 mL vs 123,0 ± 28,0 mL ; p < 0,001). Les valeurs d’IP des artères utérines n’ont pas été modifiées de manière significative, tandis que les valeurs d’IR ont augmenté significativement des deux côtés (p < 0,001). Aucune corrélation significative n’a été observée entre les variations de l’IR, la diminution du score PBAC et la réduction du volume utérin. Une aménorrhée a été observée chez 21,5 % des patientes à 12 mois. Aucun cas de maladie inflammatoire pelvienne ni de formation de kyste ovarien n’a été rapporté. Conclusions : Chez les femmes atteintes d’adénomyose symptomatique, le SIU-LNG est associé à une amélioration clinique et hématologique significative ainsi qu’à une réduction du volume utérin à 12 mois. L’augmentation observée de l’indice de résistance des artères utérines suggère que des modifications hémodynamiques pourraient participer à la réduction des saignements, en complément de la suppression endométriale, bien que cette relation demeure exploratoire. Le SIU-LNG apparaît ainsi comme une option thérapeutique efficace, bien tolérée et conservatrice de l’utérus dans la prise en charge de l’adénomyose symptomatique.
Myomectomy in pregnancy
(GLOWM, 2026) Tinelli, Andrea; Pecorella, Giovanni; Panese, Gaetano; Morciano, Andrea; Mykhailo, Medvediev V; Hatırnaz, Şafak; Aydın, Gerçek; Bıyık, İsmail; Stojković, Marta; Sparic, Radmila; Stark, Michael
Uterine fibroids, or leiomyomas, are the most common benign tumors of the uterus, arising from the smooth muscle (myometrium). They represent a major global health concern due to their impact on physical health, quality of life and economic wellbeing.1 During a woman's life cycle, uterine fibroids typically occur less frequently before puberty, are more common during the reproductive years and reduce in size after menopause.1 Histological studies indicate that uterine fibroids are characterized by three main features: increased sensitivity to sex steroid hormones, altered extracellular matrix deposition and enhanced proliferation of smooth muscle cells.2 Epidemiological research has identified several risk factors associated with leiomyoma growth, including age, ancestry, family history, reproductive factors, hormonal influences, hypertension and certain infections. Furthermore, specific dietary components may influence hormone-related diseases and the development of fibroids.
Neurobiology of cancer: A review from psychooncologic and neuroscientific perspective
(Lut Tamam, 2026) Savaş, Esra
This review emphasizes the need to understand not only the biological but also the psychological and neurobiological aspects of cancer. Factors such as psychosocial stress, depression and social isolation have important effects on cancer initiation and progression through the neuroendocrine system and the immune system. In this context, the effects of interactions between the nervous system and the immune system on the tumor microenvironment, neuroinflammation and neurotransmitter levels are detailed. In addition, the neurobiological effects of cancer treatments (chemotherapy, radiotherapy, hormone therapy, immunotherapy) on cognitive and emotional functions were discussed; “chemobrain”, neuropathic pain and treatment-related neurocognitive impairments were explained. Recent research has shown that these effects can be mitigated by psychooncological approaches such as Cognitive Behavioral Therapy, Eye Movement Desensitization and Reprocessing Therapy and mindfulness. These interventions support neuroplasticity by regulating stress responses and their effects on brain regions are supported by neuroimaging studies. Finally, the critical role of neuropsychological assessments and cognitive rehabilitation programs in individualized intervention processes was emphasized and the importance of an interdisciplinary approach was revealed. This study aims to critically evaluate the existing literature and draw attention to the gaps in the research field by comprehensively examining the neurobiological and psychooncological effects of cancer.
