Browsing by Author "Üner, Melike"
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Development of lipid nanoparticles for transdermal loteprednol etabonate delivery
Üner, Burcu; Özdemir, Samet; Taş, Çetin; Özsoy, Yıldız; Üner, Melike (Taylor and Francis, 2022)Aim Loteprednol etabonate (LE) is a new generation corticosteroid that is used for the treatment of inflammatory and allergic conditions of the eye. Therefore, solid lipid nanoparticles (SLN) and nanostructured lipid ... -
Development of monolithic matrix type transdermal patches containing cinnarizine: physical characterization and permeation studies
Damgalı, Şükran; Özdemir, Samet; Kaya, Gizem; Barla Demirkoz, Aslı; Üner, Melike (Universidade de São Paulo, 2022)To overcome the problems associated with bioavailability and systemic side effects of the drug by oral administration, monolithic matrix type transdermal patches containing cinnarizine (CNZ) were developed. For this purpose, ... -
Influence of vehicles and penetration enhancers on the permeation of cinnarizine through the skin
Damgalı, Şükran; Özdemir, Samet; Barla Demirkoz, Aslı; Üner, Melike (Galenos Publishing House, 2022)Objectives: The aim of this study was to determine the influence of vehicles and penetration enhancers on the penetration and permeation of cinnarizine (CNZ) through the skin. Materials and Methods: Topical formulations ... -
Loteprednol loaded nanoformulations for corneal delivery by quality by design concepts: Optimization, characterization, and anti infammatory activity
Üner, Burcu; Özdemir, Samet; Taş, Çetin; Üner, Melike; Özsoy, Yıldız (Springer, 2023)Loteprednol etabonate (LE) is a topical corticosteroid that uses inflammatory conditions of the eye. It has a low ocular bioavailability and side effects such as corneal disorder, eye discharge, and ocular discomfort. ... -
Loteprednol loaded nanoformulations for corneal delivery: Ex-vivo permeation study, ocular safety assessment and stability studies
Üner, Burcu; Özdemir, Samet; Yıldırım, Ecem; Yaba, Aylin; Taş, Çetin; Üner, Melike; Özsoy, Yıldız (Editions de Sante, 2023)Purpose Loteprednol etabonate (LE) is a topical corticosteroid that is used in inflammatory and allergic conditions of the eye. Nanoformulations including solid lipid nanoparticles (SLN), nanostructured lipid carriers ...
