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    Development and characterization of viburnum opulus l. extract‑loaded orodispersible films: potential route of administration for phytochemicals
    (Springer, 2023) Özdemir, Samet; Karaküçük, Alptuğ; Çakırlı, Egemen; Sürücü, Bilge; Barak, Timur Hakan
    Purpose Viburnum opulus L. fruits have been used in traditional medicine in the Turkish population for kidney problems, hypoglycemic and cough relaxant activities. This study aimed to prepare V. opulus extract-loaded orally disintegrating films (ODFs) to enhance oral absorption and improve patient compliance. Methods ODF formulations were prepared using the solvent casting method. Carboxymethyl cellulose (0.5%, 1%, 1.5% w/w) and chitosan (0.5%, 1%, 1.5% w/w) were selected as film-forming polymers and glycerol was utilized as a plasticizer. Chlorogenic acid is the major metabolite of V. opulus fruits. The chlorogenic acid content in formulations and the plant extract was measured using high-performance thin-layer chromatography (HPTLC). Characterization studies on the formulations such as elongation at break, tensile strength, Young’s modulus, DSC, SEM, and FT-IR were conducted. Bioadhesion, in vitro disintegration, and in vitro release studies were performed. Results Desired mechanical and morphological properties were obtained for ODFs. Disintegration times (15.38 ± 0.88 s) and release studies (85.19% at 30 min) showed that the 0.5% chitosan films were the most convenient formulation for delivering V. opulus extract. Conclusion ODFs were evaluated as a smart delivery route for phytochemicals avoiding any gastrointestinal effects and enhancing oral absorption.