Development and characterization of viburnum opulus l. extract‑loaded orodispersible films: potential route of administration for phytochemicals
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose Viburnum opulus L. fruits have been used in traditional medicine in the Turkish population for kidney problems,
hypoglycemic and cough relaxant activities. This study aimed to prepare V. opulus extract-loaded orally disintegrating films
(ODFs) to enhance oral absorption and improve patient compliance.
Methods ODF formulations were prepared using the solvent casting method. Carboxymethyl cellulose (0.5%, 1%, 1.5%
w/w) and chitosan (0.5%, 1%, 1.5% w/w) were selected as film-forming polymers and glycerol was utilized as a plasticizer.
Chlorogenic acid is the major metabolite of V. opulus fruits. The chlorogenic acid content in formulations and the plant extract
was measured using high-performance thin-layer chromatography (HPTLC). Characterization studies on the formulations
such as elongation at break, tensile strength, Young’s modulus, DSC, SEM, and FT-IR were conducted. Bioadhesion, in vitro
disintegration, and in vitro release studies were performed.
Results Desired mechanical and morphological properties were obtained for ODFs. Disintegration times (15.38 ± 0.88 s) and
release studies (85.19% at 30 min) showed that the 0.5% chitosan films were the most convenient formulation for delivering
V. opulus extract.
Conclusion ODFs were evaluated as a smart delivery route for phytochemicals avoiding any gastrointestinal effects and
enhancing oral absorption.
Açıklama
Anahtar Kelimeler
Orodispersible Films, Viburnum Opulus, Bioadhesion, Bioavailability, Phytochemicals
Kaynak
Journal of Pharmaceutical Innovation
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
18
Sayı
1
Künye
Özdemir, S., Karaküçük, A., Çakırlı, E., Sürücü, B., Üner, B., Barak, T. H., & Bardakçı, H. (2023). Development and characterization of viburnum opulus l. extract‑loaded orodispersible films: potential route of administration for phytochemicals. Journal of Pharmaceutical Innovation, 18(1), pp. 90-101. https://doi.org/10.1007/s12247-022-09627-z