Development and characterization of viburnum opulus l. extract‑loaded orodispersible films: potential route of administration for phytochemicals

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dc.authorid0000-0001-6212-2706en_US
dc.authorwosidP-2971-2019en_US
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorKaraküçük, Alptuğ
dc.contributor.authorÇakırlı, Egemen
dc.contributor.authorSürücü, Bilge
dc.contributor.authorBarak, Timur Hakan
dc.date.accessioned2022-02-25T13:40:15Z
dc.date.available2022-02-25T13:40:15Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractPurpose Viburnum opulus L. fruits have been used in traditional medicine in the Turkish population for kidney problems, hypoglycemic and cough relaxant activities. This study aimed to prepare V. opulus extract-loaded orally disintegrating films (ODFs) to enhance oral absorption and improve patient compliance. Methods ODF formulations were prepared using the solvent casting method. Carboxymethyl cellulose (0.5%, 1%, 1.5% w/w) and chitosan (0.5%, 1%, 1.5% w/w) were selected as film-forming polymers and glycerol was utilized as a plasticizer. Chlorogenic acid is the major metabolite of V. opulus fruits. The chlorogenic acid content in formulations and the plant extract was measured using high-performance thin-layer chromatography (HPTLC). Characterization studies on the formulations such as elongation at break, tensile strength, Young’s modulus, DSC, SEM, and FT-IR were conducted. Bioadhesion, in vitro disintegration, and in vitro release studies were performed. Results Desired mechanical and morphological properties were obtained for ODFs. Disintegration times (15.38 ± 0.88 s) and release studies (85.19% at 30 min) showed that the 0.5% chitosan films were the most convenient formulation for delivering V. opulus extract. Conclusion ODFs were evaluated as a smart delivery route for phytochemicals avoiding any gastrointestinal effects and enhancing oral absorption.en_US
dc.identifier.citationÖzdemir, S., Karaküçük, A., Çakırlı, E., Sürücü, B., Üner, B., Barak, T. H., & Bardakçı, H. (2023). Development and characterization of viburnum opulus l. extract‑loaded orodispersible films: potential route of administration for phytochemicals. Journal of Pharmaceutical Innovation, 18(1), pp. 90-101. https://doi.org/10.1007/s12247-022-09627-zen_US
dc.identifier.doi10.1007/s12247-022-09627-zen_US
dc.identifier.endpage101en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85125131976en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage90en_US
dc.identifier.urihttps://doi.org/10.1007/s12247-022-09627-z
dc.identifier.urihttps://hdl.handle.net/20.500.13055/162
dc.identifier.volume18en_US
dc.identifier.wosWOS:000760691700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorÖzdemir, Samet
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Pharmaceutical Innovationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOrodispersible Filmsen_US
dc.subjectViburnum Opulusen_US
dc.subjectBioadhesionen_US
dc.subjectBioavailabilityen_US
dc.subjectPhytochemicalsen_US
dc.titleDevelopment and characterization of viburnum opulus l. extract‑loaded orodispersible films: potential route of administration for phytochemicalsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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