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  • Küçük Resim
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    Gender differences in the distribution of IDL, LDL, and HDL lipoprotein subfractions in MODY compared to type 2 diabetes: Data from the MODY-Ist study
    (Elsevier, 2025) Yılmaz Aydoğan, Hülya; Kanca Demirci, Deniz; Gül, Nurdan; Yanar, Fatih; Poyrazoğlu, Şükran; Güleç Yılmaz, Seda; Tüzüner, Mete Bora; İsbir, Turgay; Öztürk, Oğuz; Satman, İlhan
    Background: The distribution of intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL) and high density lipoprotein (HDL) subfractions specific to diabetes types and changes under dyslipidemia conditions have been well characterised. Research into the distribution of lipoprotein subfractions in Maturity-Onset Diabetes of the Young (MODY) has hitherto been confined to certain subtypes, with gender-based differences remaining to be elucidated. The objective of this study was to comparatively evaluate the distribution of lipoprotein subfractions according to gender in MODY, T2DM patients, and control groups. Methods: Lipoprotein subfractions in 119 serum samples of the study groups were analyzed using the Lipoprint System. Results: The midbands of IDL (MID-A to C) in female MODY cases, and the HDL-small fraction in male MODY cases, were found to be lower compared to female and male T2DM cases, respectively. In the T2DM group, age was positively correlated with MID-C and MID-B in both genders, while it was negatively correlated with MID-A in female cases. ROC analysis demonstrated that the decrease in the MID-C fraction in female MODY subjects (AUC:0.809, p = 0.0001) and the decrease in the HDL-small fraction in male MODY subjects (AUC:0.818, p = 0.002) were significantly associated with the likelihood of MODY. Conclusion: Given that a considerable proportion of MODY patients are frequently misdiagnosed as T2DM, low levels of MID-C and HDL-small fractions, both of which are triglyceride-rich, may have potential as a diagnostic value for female and male MODY patients, respectively.
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    Obezite ve meme kanseri arasındaki biyolojik bağlantılar: Hücresel ve moleküler düzeyde etkileşimler
    (Orient Yayınları, 2025) Tüzüner, Mete Bora; Teoman AKÇAY; Haspolat, Yusuf Kenan; Akçay, Teoman; Orbak, Zerrin
    Obezite, başta meme kanseri olmak üzere pek çok kanser türünün görülme sıklığını ve ilerleyişini artıran önemli bir risk faktörüdür. Obezite ile meme kanseri arasındaki ilişki, karmaşık ve çok katmanlı biyolojik süreçlerle şekillenir; bu süreçlerin merkezinde metabolik ve immün sistem bozuklukları yer alır. Özellikle beyaz adipoz dokusunda (WAT) ortaya çıkan kronik düşük dereceli inflamasyon, proinflamatuvar sitokinlerde artış, alternatif makrofaj aktivasyonu ve T hücresi işlevlerinde azalma gibi bağışıklık sistemi düzensizliklerine yol açar. Meme dokusunun büyük ölçüde WAT’tan oluşması, gelişmekte olan tümör hücrelerinin obezite ile yeniden programlanmış mikroçevreyle doğrudan etkileşim hâlinde ol masına olanak tanır.
  • Küçük Resim
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    Periodontal hastalıklar ve kanser gelişimindeki etkileri
    (Orient Yayınları, 2025) Tüzüner, Mete Bora; Arslan, Semiha; Haspolat, Yusuf Kenan; Atılgan, Serahim Serhat
    Kanser, dünya genelinde ölüm nedenleri arasında ikinci sırada yer almakta olup, her yıl yaklaşık 10 milyon insanın yaşamını yitirmesine neden olmaktadır. Küresel ölçekte her yıl yaklaşık 19 milyon yeni kanser vakası teşhis edilmekte, en yaygın görülen kanser türleri arasında meme, akciğer, kolorektal, pankreas ve mide kanserleri öne çıkmaktadır (1). Etkili birincil koruma ve tedavi stratejileri halen sınırlı olup, bu stratejilerin başarıyla uygulanabilmesi, kanser oluşumuna ilişkin moleküler mekanizmaların daha iyi anlaşılmasına ve değiştirilebilir risk faktörlerinin hedeflenmesine bağlıdır.
  • Küçük Resim
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    Proteomic analysis revealed underlying biological pathways associated with hormetic response of hormone- positive breast cancer cell line exposed to low-dose flavonoid mixture
    (Istanbul University, 2021) Tüzüner, Mete Bora; Ceviz, Ayşe Begüm
    Objective: A considerable level of evidence has accumulated about the breast cancer risk-reducing effect of consuming specific flavonoids, through the increasing amount of research and epidemiologic studies. Different flavonoids may have different cellular bioavailability and favor, i.e., the occurrence of a hormetic effect, thus it is important to evaluate breast cancer cells’ response to different doses of flavonoids. This study aims to investigate the alterations of the biological pathways in a hormone-positive (HR+) breast cancer cell line as a resemblance for the most common breast cancer subtype, related to the low-dose exposure of the flavonoids. Materials and Methods: Different levels of doses were applied to MCF-7 breast cancer cells. In order to determine cellular proliferation, WST-1 analysis was conducted. The highest proliferation was observed with cell lines exposed to a low-dose flavonoid mixture and these were selected for further analysis. Intracellular protein expression were investigated by peptide analysis on a nano LC-MS/MS platform. A protein-protein interaction network and pathway analysis were conducted for the proteins expressed differently between the groups. Results: A total of 214 proteins were identified and 36 proteins with significant alterations (≥1.2-fold change, p≤0.05) were detected. Significant changes were observed in the pathways related to carbon metabolism, amino acid biosynthesis, splicing mechanism, mitochondrial protein import and translation elongation pathways. Conclusion: Our study demonstrated that flavonoids can have a hormetic effect which can initially alter metabolic pathways vital for cell proliferation and survival. These pathways may include potential targets for enhancing the anticancer activity of the flavonoids