Kimya Mühendisliği Bölümü Koleksiyonu

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https://hdl.handle.net/20.500.13055/46

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Waste toner particles based dispersive solid phase extraction for the trace determination of cadmium in cinnamon tea samples by flame atomic absorption spectrometry
(Elsevier, 2026) Ali, Büşra; Büyük, Muhammed Ali; Bayraktar, Ahsen; Serbest, Hakan; Bakırdere, Sezgin
This study presents a dispersive solid phase extraction (DSPE) protocol for the sensitive and accurate determi nation of trace levels of cadmium ions (Cd2+) by flame atomic absorption spectrometry (FAAS). Toner particles obtained from used printer cartridges were used as sorbent material for preconcentration of Cd2+ ions. Opti mization studies were performed univariately for the achievement of the highest extraction efficiency and the limit of detection (LOD) was found to be 0.55 µg L-1 under optimal operating conditions. By comparing the slopes of the linear plot equations for FAAS and waste toner-based DSPE-FAAS systems, the increase in sensitivity was calculated to be 40.9 times. The feasibility of the developed method was evaluated by spiking recovery studies on cinnamon tea samples and good recovery results between 90.4 % and 119.0 % determined by the matrix matching calibration strategy showed that the method is applicable to cinnamon tea and similar matrices.
Optimization of VA-NADES-ME for the one-step separation and determination of rhodamine B and rhodamine 6G in red pencil samples
(Taylor & Francis, 2025) Topraksever, Nükte; Özgül Artuç, Gamze
An environmentally friendly and simple method was developed for the simultaneous separation and determination of Rhodamine B (RhB) and Rhodamine 6 G (Rh6G) in red pencil samples by vortex assisted microextraction using NADES (Natural Deep Eutectic Solvent). A two-phase system was established using lactic acid-based DES (Deep Eutectic Solvent) and tetrahydrofuran (THF) for the extraction of RhB and Rh6G. In method optimization, sample amount, pH, DES type, DES volume, solvent type and solvent volume parameters were investigated. Limit of detection (LOD) and limit of quantification (LOQ) values were 4.13, 5.03 and 12.5, 15.3 µg/mL for RhB and Rh6G, respectively. The correlation coefficients obtained at concentrations ranging from 1–12 µg/mL are 0.9973 and 0.9985. Red pencil samples were spiked at two different concentrations (3–5 µg/mL). The recovery values obtained were in the range of 84.7%-107.4%. The relative standard deviation (RSD) values of the developed method are in the range of 2.77%-5.45%, indicating that the method is reproducible. The results showed that the developed microextraction method can be success fully applied for the separation and determination of RhB and Rh6G from red pencil samples.
Quantitative determination of α-tocopherol and α-tocopheryl acetate in pharmaceutical and supplementary soft capsules by high performance liquid chromatography
(İstanbul Gelisim University, 2025) Topraksever, Nükte; Özgül Artuç, Gamze
Aim: This study aims to determine the amounts of α-tocopherol (α-toc) and α-tocopheryl acetate (α-tocAc) in soft pharmaceutical capsules and supplements using a chromatographic method. Additionally, method validation parameters for both analytes were evaluated. Method: Analyses were performed using a chromatographic method. As part of the method validation, recovery (% recovery), repeatability (% RSD), linear regression coefficient (R²), limit of detection (LOD), and limit of quantification (LOQ) values were determined. Results: The recovery values were found to be above 95%. Repeatability (%RSD) was calculated as <3%. The linearity (R²) values were obtained as 0.999. For α-toc: LOD: 0.131 µg/mL and 2.228 µg/mL, LOQ: 0.396 µg/mL and 6.752 µg/mL. For α-tocAc: LOD: 0.260 µg/mL, LOQ: 0.787 µg/mL. Conclusion: The chromatographic method used in this study enabled the determination of α-toc and α tocAc with high accuracy and repeatability. This method can be considered a reliable alternative for the analysis of these compounds in pharmaceutical products.
Phocatalytic dye degradation activities of chitosan film modified by green synthesized tio2 from aloe vera leaf extract
(Avestia Publishing, 2025) Kaba, İbrahim; Bozkurt, Rabia Nur; Kerkez Kuyumcu, Özge; Koca, Atıf
Recent research focuses on heterogeneous photocatalysis, an environmentally friendly and cost-effective method that uses solar energy to completely degrade pollutants without generating secondary waste. The focus is optimizing the properties of photocatalysts in terms of electronic structure, light absorption, and reduced recombination rate of photogenerated charges and easy separation of the photocatalyst from reaction media [1]. The potential for efficient, sustainable heterogeneous photocatalysis has been demonstrated by semiconductors such as TiO₂, ZnO, Fe₂O₃, CdS, CuS, and ZnS [2]. TiO₂ is regarded as one of the most effective photocatalysts. The usage of TiO₂ for the degradation of hazardous organic dyes in wastewater has significant potential. The separation of the photocatalyst from the reaction medium remains a significant challenge in photocatalytic applications. In particular, the recovery of TiO₂ after the degradation of organic dyes poses a considerable difficulty, as its fine particulate nature hampers efficient separation from the treated solution. One of the strategies in this regard is the immobilization of the photocatalyst by embedding it into a polymer matrix. This approach facilitates easier separation of the photocatalyst from the reaction medium [3]. Chitosan, a natural biopolymer widely used for its biodegradability and biocompatibility, is an attractive candidate for hydrogel development due to its functional groups that serve as cross-linking sites during hydrogel formation. It has also been combined with photocatalysts and utilized in numerous studies [4-6]. In this study, green-synthesized TiO₂-embedded chitosan films (Bio-TiO₂-CS films) prepared using aloe vera leaf extract offer the advantage of facile separation after the degradation process, as well as potential reusability following dye removal. As the goal of the study, it is believed that the obtained chitosan film hydrogels can be used as an effective bio-template material to disperse TiO2 nanostructures due to their three-dimensional porous structure and appropriate nanopore size distribution, and this feature has led us to investigate the simpler, recyclable, green approach, and biomaterial development of the use of Bio-TiO₂-CS Hydrogel Films in photocatalytic dye removal from water.
FeSbO4 nanomalzeme destekli katı faz mikroekstraksiyonu kullanarak nikel tayini için duyarlı bir analitik yöntemin geliştirilmesi
(Yıldız Technical University Publishing, 2025) Büyük, Muhammed Ali; Serbest, Hakan; Bakırdere, Sezgin
Bu çalışmada, alevli atomik absorpsiyon spektrometresine entegre edilen katı faz mikroekstraksiyon yöntemiyle nikel (Ni) elementinin ön deriştirilmesi amaçlanmıştır. Katı faz adsorbanı olarak FeSbO₄ kimyasal bileşimine sahip, doğal bir mineral yapı olan tripuhit tercih edilmiştir. Laboratuvar ortamında sentetik olarak elde edilen bu nanoyapılar, sırasıyla ultra saf su ve kekik çayı örnekleri içerisindeki nikel iyonlarını yüzeylerine adsorplayarak ekstraksiyon işlemi için kullanılmıştır.
Aloe vera-derived Ag-doped TiO2 nanoparticles immobilized by chitosan films for photo(electro)catalytic and antimicrobial functions
(Elsevier, 2025) Kaba, İbrahim; Bozkurt, Rabia Nur; Altıner Kurt, Eda; Kerkez Kuyumcu, Özge; Koca, Atıf
In this study, as an environmentally friendly and sustainable approach, TiO2 nanoparticles (TiO2 NPs) were prepared by green synthesis method using deep eutectic solvent (DES, ChCl/glycerol (1:2)) based Aloe vera leaves extract obtained by Soxhlet extraction. The DES system functioned concurrently as a green solvent and a functional medium, while the bioactive chemicals in the Aloe vera leaves extract operated as natural reducing and stabilizing agents. The produced TiO2 NPs were doped with silver (Ag) at molar ratios of 0.25, 0.50, and 0.75, and immobilized on a chitosan matrix (Ag/TiO2-CS) to facilitate recovery from the reaction media. The materials were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-Vis), photoluminescence (PL) spectroscopy, scanning electron microscopy-energy dispersive X ray analysis (SEM-EDX) and X-ray photoelectron spectroscopy (XPS). Characterization validated the TiO2 phase, effective Ag incorporation, diminished band gap energy (from 3.34 eV to 2.83 eV), and uniform nanoparticle distribution. PL measurements confirmed that Ag doping reduces carrier charge recombination. The 0.50Ag/ TiO2-CS film displayed the best photocatalytic degradation efficiency for malachite green (93.3 %) under solar irradiation and exhibited a higher photocurrent response relative to undoped TiO2. Moreover, antimicrobial assays demonstrated that 0.50 and 0.75 Ag/TiO2 NPs exhibited significant suppression of S. aureus and E. coli, with low minimum inhibitory concentrations (MIC) (0.40–0.20 µg/mL) and minimum bactericidal concentra tions (MBC), signifying robust bactericidal efficacy. The findings indicate that DES-assisted Aloe vera-mediated synthesis provides an economical and scalable method for producing multifunctional nanocomposites with considerable potential in environmental remediation and biomedical fields.
Phase-selective synthesis of nanoshell hollow V2O3 and V3O5 microspheres as high-performance cathodes for aqueous Zn-ion batteries
(Elsevier, 2025) Aydın Şahin, Selay; Aydoğdu, Büşra; Yaman Uzunoğlu, Gülşah; Yüksel, Recep
Divanadium trioxide (V2O3) microspheres having nano-sized shells were produced by a facile and cost-efficient solvothermal method. Thermal treatment of V2O3 yielded trivanadium pentoxide (V3O5) microspheres. After the synthesis, the structural and electrochemical characterizations were performed in detail. Cathodes produced with the V2O3 and V3O5 materials reached specific capacities of 388 and 320 mAh g− 1 , respectively, at a current density of 0.1 A g− 1 . Aqueous zinc-ion batteries (ZIBs) fabricated with V2O3 and V3O5 cathodes demonstrated high-rate capability and capacity retention. The V2O3 microspheres, which possess a rhombohedral corundum type structure, showed outstanding rate capability (412 mAh g− 1 at 0.1 A g− 1 ; 149 mAh g− 1 at 20 A g− 1 ) and notable cycling stability (95.6 % capacity retention after 1200 cycles at 2 A g− 1 ; 80 % retention at the 2400th cycle at 5 A g− 1 ). Conversely, monoclinic V3O5 provided a comparable initial capacity (374 mAh g− 1 at 0.1 A g− 1 ) but faced rapid capacity decline at high current (26 % retention after 6000 cycles at 5 A g− 1 ). These results emphasize the significance of crystal structure in achieving stable and high-rate Zn2+ storage. In summary, the rhombohedral V2O3 phase exhibits superior Zn2+ transport kinetics and mechanical strength compared to the monoclinic V3O5, which accounts for the differences observed in their electrochemical performance.
Lowered phase transition temperature of VO2(m) via molybdenum doping toward efficient aqueous zinc-ion batteries
(Wiley, 2025) Aydın Şahin, Selay; Aydoğdu, Büşra; Yaman Uzunoğlu, Gülşah; Yüksel, Recep
Rechargeable aqueous zinc-ion batteries have attracted considerable attention as large-scale energy storage systems owing to their safety, sustainability, and cost-effectiveness. However, their practical application has been hindered by limited energy density, primarily determined by cathode performance. Among transition metal oxides, vanadium dioxide (VO2) is particularly appealing due to its layered structure, rich polymorphism, and ability to host Zn2+ ions reversibly. The thermally driven transition from insulating VO2(M) to conductive VO2(R) enhances charge transport through the metal–insulator transition (MIT). In this work, molybdenum doping is employed to lower the MIT temperature of VO2(M). Doping reduces the MIT temperature of the VO2(M) phase to 56.7 °C, resulting in the VO2(R) phase. Electrochemical measurements reveal that Mo-VO2(R) cathodes deliver up to ten times higher capacity than the pristine VO2(M), with 3Mo-VO2(R) reaching 404.8 mAh g–1 at 0.1 A g–1. These findings demonstrate that Mo doping serves as a practical approach to modify VO2(M) and decrease the MIT temperature, while improving electrochemical performance. Moreover, the heteroatom doping strategy suggests a promising pathway for developing other VO2 cathodes for efficient rechargeable batteries, which can leverage the heat dissipated in energy storage systems.
Chia seeds-based gel electrolyte for sustainable and stable zinc ion batteries
(ESC-IS, 2025) Yaman Uzunoğlu, Gülşah
Aqueous zinc batteries represent a promising option for energy storage and conversion technologies in the "post-lithium" era, owing to their elevated energy density, enhanced safety, and affordability. Rechargeable aqueous zinc ion batteries (RZBs) are recognized as promising alternatives to lithium-ion batteries due to their cost-effectiveness, safe-and-sustainable by-design, and scalability. Nonetheless, their performance is hindered by inadequate cyclability, which is attributed to dendrite formation and the hydrogen evolution reaction (HER) occurring at the zinc anode [1].
Synthesis and supramolecular architectures of novel hydrazine derivative homometallic schiff base complexes and their spectroscopic and thermal chacterization
(Springer Nature Link, 2025) Temizkan Özdamar, Kevser
In this study, a hydrazine-containing Schiff base (ScB) and its metal complexes with five different metals—Co (ScB Co), Cu (ScB-Cu), Pb (ScB-Pb), Mn (ScB-Mn), and Zn (ScB-Zn)-were synthesized and subsequently characterized both structurally and thermally. The ScB was synthesized via an elimination reaction between vanillin and phenylhydrazine in ethanol. Hexadentate homometallic complexes (HMCs) were then obtained by reacting the ScB with five different metal salts in tetrahydrofuran. The structural architecture of the synthesized ScB and its HMCs was elucidated using Fourier Transform Infrared (FT-IR) spectroscopy, as well as proton (1 H) and carbon (13C) Nuclear Magnetic Resonance (NMR) spectroscopy. Optical, thermal, and surface characterizations of the structurally confirmed ScB and HMCs were performed using UV-Visible spectroscopy (UV-Vis), thermogravimetric and differential thermogravimetric analyses (TG-DTG), and scanning electron microscopy (SEM), respectively. According to thermogravimetric analysis, the char yield of ScB was 28.2%, while the char yields of its metal complexes—ScB-Co, ScB-Cu, ScB-Pb, ScB-Zn, and ScB-Mn—were 5.4%, 27%, 16%, 19%, and 7.1%, respectively. These results indicate that the incorporation of metal ions into the structure reduced its thermal stability, as evidenced by the decreased residue amounts at 1000 °C.
Aloe vera ve ayva çekirdeği müsilajı içeren aljinat türevli biyobozunur filmlerin üretimi ve karakterizasyonu
(Çanakkale Onsekiz Mart Üniversitesi, 2025) Keke, Zeynep Serra; Temizkan Özdamar, Kevser
Bu çalışma, biyobozunur ve fonksiyonel film üretimi amacıyla ayva çekirdeği musilajı ve aloe vera jeli içeren sodyum aljinat bazlı biyopolimer filmlerin sentezini ve karakterizasyonunu kapsamaktadır. Ayva çekirdeği, yüksek viskozite sağlayan doğal polisakkarit içeriği ile film matrisine mukavemet kazandırırken, aloe vera jeli antimikrobiyal ve antioksidan özellikleriyle biyolojik aktiviteyi güçlendirmektedir [1, 2]. Sodyum aljinat, biyouyumluluk ve film oluşturma kabiliyeti yüksek bir hidrojel olması nedeniyle temel taşıyıcı polimer olarak seçilmiştir [3]. Bu çalışma kapsamında, dört farklı hidrojel film formülasyonu hazırlanmıştır. Her bir formülasyon, sodyum aljinat, aloe vera, ayva çekirdeği, selüloz hidroksi etil selüloz (HEC) ve gliserol bileşenlerinin belirli oranlarda karıştırılmasıyla oluşturulmuştur. Film yapısında bulunan bileşenlerin birbirleriyle olan kimyasal ve fiziksel etkileşimleri, malzemenin mekanik ve fonksiyonel özelliklerini belirlemektedir. Film üretiminde solvent dökme yöntemi uygulanmış ve karakterizasyon aşamasında mekanik dayanım, su buharı geçirgenliği, biyobozunurluk ve antibakteriyel aktivite parametreleri değerlendirilmiştir. Fourier Dönüşümlü Kızılötesi Spektroskopisi (FTIR), UV-Vis Spektroskopisi ve Termogravimetrik Analiz (TGA) ile kimyasal yapı ve termal stabilite analizleri gerçekleştirilmiştir. Biyobozunurluk testleri, filmlerin çevresel koşullarda zamanla parçalanabilir olduğunu gösterirken, antibakteriyel testler inhibisyon etkisini doğrulamıştır. Elde edilen sonuçlar, ayva çekirdeği ve aloe vera içeren biyopolimer filmlerin sürdürülebilir ve çevre dostu bir alternatif sunduğunu göstermektedir. Bu bulgular, organik çözücü ve yüksek sıcaklık kullanmaksızın, biyobozunur malzemeler üzerine yapılan araştırmalara katkı sağlaması hedeflenmektedir.
Investigation of photocatalytic degradation of methyl orange using zinc oxide-supported chitosan hydrogel beads
(Taylor & Francis, 2025) Kaba, İbrahim; Bozkurt, Rabia Nur; Kılıç, Behris
In this study, chitosan-based ZnO supported hydrogels (CZ–H) were synthesized to evaluatetheir photocatalytic degradation performance against methyl orange (MO) dye. The compos-ite hydrogels were characterized using X-ray Diffraction (XRD), UV–Vis DRS, ScanningElectron Microscopy (SEM-EDS), Thermogravimetric Analysis (TGA), and Fourier TransformInfrared Spectroscopy (FTIR). These characterization results confirmed the successful forma-tion of the CZ–H composite structure. The band gap of the composite was approximately2.77 eV, supporting enhanced photocatalytic activity. Photocatalytic experiments showedthat CZ–H removed 74% of MO within 60 min, compared to 42% for pure chitosan beads,with reaction rate constants of 0.0237 min−1 and 0.0113 min−1, respectively. Moreover, theCZ–H beads demonstrated good reusability with minimal loss in efficiency over multiplecycles. These findings highlight the potential of CZ–H as a stable, effective, and reusablephotocatalyst for the efficient removal of dyes from wastewater.
Improving physiological solubility and gene transfer efficiency of chitosan via 3-nitrobenzaldehyde and amino acid conjugation
(Elsevier, 2025) Bal, Kevser; Kaplan, Özlem; Şentürk, Sema; Küçükertuğrul Çelik, Sibel; Demir, Kamber; Gök, Mehmet Koray
In this study, chitosan was chemically modified with 3-nitrobenzaldehyde (3NBA) and three amino acids (arginine, cysteine, and histidine) to enhance its gene delivery performance. 3-NBA was selected for its known DNA binding properties, while the amino acids were chosen based on their functional groups, which can improve solubility, facilitate cellular uptake, and contribute to endosomal escape. The modified chitosan polymers were characterized using Fourier Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance Spectroscopy (NMR). Nanoparticles were prepared using the ionotropic gelation method, and their particle size, polydispersity index (PDI), zeta potential were analyzed by dynamic light scattering (DLS). The particle sizes ranged from 105.07 ± 3.45 to 206.15 ± 10.39 nm, with PDI values between 0.29 ± 0.01 and 0.39 ± 0.02. Zeta potentials were measured between 32.05 ± 0.49 mV and 51.95 ± 0.35 mV. The cysteine-modified chitosan (Chi-3NBACys) exhibited approximately 8.4-fold higher solubility than unmodified chitosan. In vitro studies demonstrated that the modified chitosan nanoparticles exhibited low cytotoxicity in HEK293T cells. Among the tested formulations, Chi-3NBACys showed the highest transfection efficiency, comparable to commercial agent Lipofectamine™ 2000. These findings suggest that chitosan nanoparticles modified with 3-NBA and amino acids can be safe and efficient non-viral gene delivery vectors.
Tailoring natural solvents: Deep eutectic approach for recovering bioactives from Prunus Spinosa L.
(Wiley, 2025) Bozkurt, Rabia Nur; Falsafi, Seid Reza; Şahin, Selin
In this study, several choline chloride (ChCl)-based deep eutectic solvent (DES) combinations were prepared at different molarratios (1/1, 1/2, and 2/1) using amine (urea), polyols (ethylene glycol and glycerol), and carboxylic acids (lactic acid, formic acid,propionic acid, and acetic acid). The performances of the DESs in the homogeniser-assisted extraction of Prunus spinosa L.fresh fruit were compared depending on the total phenolic content (TPC), total anthocyanin content (TAC), and 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity (antioxidant activity [AA]) yields. Based on the findings of Tukey’s test formultiple comparisons, ChCl/formic acid (2/1) provided the best extraction efficiency with statistically significant differences(p < 0.05). Fourier-transform infrared spectroscopy was used to confirm the formation of the proposed DES. Furthermore, theproposed DES also showed better performance compared to conventional aqueous ethanol (60%, v/v) and water. Then, theselected DES (ChCl/formic acid, 2/1) was employed for the optimization study using the Box-Behnken Design of the responsesurface methodology. The optimum process conditions for the maximum yields of TPC (52.34 mg-GAE/g-FF), TAC (2.09 mg-cyn-3-glu/g-FF), and AA (89.21%) were found to be 50% (v/v) water in the DES, 0.833 g of material, and 69.906 s extractiontime.
Gas hydrates as a new energy resource
(Briq Journal, 2025) Çifci, Günay; Çelebi, Serdar Suut; Parlaktuna, Mahmut; Kaçar, Aslı; Okay Günaydın, Seda
Gas hydrates, solid ice-like structures formed by water and methane molecules, are emerging as a critical future energy resource, offering abundant reserves of cleaner-burning methane. These reserves have the potential to enhance energy security, diversify energy portfolios, and support the transition from traditional hydrocarbons to more sustainable energy systems. Globally, nations such as Japan, China, the United States, India, South Korea, and Canada are leading research and development in gas hydrates, making substantial investments in advanced technologies and field tests. These efforts aim to overcome the significant technical and economic challenges currently limiting commercial-scale production. Türkiye's proximity to significant gas hydrate deposits, particularly in the Black Sea, presents a notable strategic opportunity. It is imperative that Türkiye capitalizes on this unique positioning by transforming these inherent advantages into long-term competitive strengths. The confirmed gas reserves in the Black Sea exemplifies such potential.
Unleashing the hidden potential: The transformative influence of occupational health and safety education on chemical engineers
(Sakarya University, 2025) Dilek, Sümeyye; Özdemir Olgun, Fatoş Ayça
Occupational Health and Safety (OHS) education plays a crucial role in shaping the professional development of chemical engineers, equipping them with the necessary knowledge and skills to ensure workplace safety and prevent occupational hazards. This manuscript presents a comprehensive review of the impacts of OHS education on chemical engineers, focusing on its role in enhancing awareness, knowledge acquisition, and practical application. The study explores the influence of OHS education on promoting a safety culture, improving risk assessment and management practices, and fostering a proactive approach towards identifying and mitigating occupational hazards. It also investigates the effects of OHS education on job satisfaction, professional growth, and career opportunities within the chemical engineering field. By analyzing relevant literature and case studies, this review provides valuable insights into the positive outcomes resulting from integrating OHS education into the curriculum at universities. The findings emphasize the significance of OHS education in cultivating competent and safety-conscious chemical engineers who contribute to sustainable and responsible industrial practices.
Comparing the effects of halloysite nanotubes and precipitated calcium carbonate nanoparticles on the environmental stress cracking resistance and mechanical properties of polycarbonate
(Wiley, 2025) Aktaş, Deniz; Taşdemir, Hacı Abdullah; Alanalp, Mine Begüm; Durmuş, Ali
Polycarbonate (PC) is a versatile and amorphous engineering thermoplastic used in various areas due to its exceptional me-chanical and thermal properties. However, its susceptibility to environmental stress cracking limits its industrial application inchemically aggressive environments. This study investigates the effects of incorporating surface-modified halloysite nanotubes(HNTs) and precipitated calcium carbonate (PCC) as nanofillers on the mechanical properties and environmental stress cracking(ESC) resistance of PC. PC nanocomposites were prepared with varying filler concentrations (1%, 3%, and 5% by weight) usingtwin-screw extruder and injection molding devices. Comprehensive mechanical characterization, including three-point bending, Charpy impact toughness, and Shore D hardness tests, revealed that introducing 1 wt% of HNT optimally balances stiffness,toughness, and ESC resistance. PCC, on the other hand, significantly improved processability but demonstrated poor ESC perfor-mance, with samples failing within an hour in methanol immersion tests. ESC resistance testing in methanol and sodium laurylether sulfate (SLES) solutions confirmed the superior performance of HNT-reinforced PC nanocomposites. Scanning electronmicroscopy (SEM) analyses provided insights into filler-matrix interactions and crack propagation mechanisms. These findingsoffer valuable guidance for the development of PC nanocomposites tailored for automotive, electronics, and chemical processingindustries.
An analytical method for the determination of pentachloroaniline and pentachlorobenzene in ginseng tea samples by gas chromatography–mass spectrometry after liquid phase microextraction
(Elsevier, 2025) Erarpat Bodur, Sezin; Serbest, Hakan; Bakırdere, Sezgin
This study describes a sensitive and accurate analytical method for the determination of pentachloroaniline (PCA) and pentachlorobenzene (PCB) at trace levels in ginseng tea samples. For this purpose, spraying based fine droplet formation liquid phase microextraction (SFDF-LPME) method was implemented to extract/preconcentrate the target analytes before their separation and detection by gas chromatography-mass spectrometry (GC-MS). Herein, a lab-made spraying system was used to distribute the extraction solvent throughout the aqueous sample solution. Limit of detection/quantitation (LOD/LOQ) values for PCA and PCB were found as 0.24/0.80 and 0.26/0.85 μg/kg, respectively. When LOD values of GC-MS and SFDF-LPME-GC-MS methods were compared to each other, enhancement in detection power values for PCA and PCB were 285 and 226.9 folds, respectively. Percent recovery results for PCA and PCB were calculated as 92-124 % and 86-129 %, respectively. Green evaluation and practicability of developed SFDF-LPME-GC-MS method was done by Eco-scale (89), AGREEprep (0.39) and BAGI (62.5) tools.
The role of hexagonal boron nitride (h-BN) in enhancing electrolytes for safer and efficient lithium-based batteries
(Elsevier, 2025) Yaman Uzunoğlu, Gülşah; Coşkun, Şahin; Yüksel, Recep
Hexagonal boron nitride (h-BN), with its unique structural and thermal properties, has emerged as a versatile material capable of addressing challenges such as thermal instability, dendrite formation, and limited ionic conductivity across liquid, gel polymer, and solid-state electrolytes (SSEs) for high-performing lithium ion and lithium metal batteries (LMBs). In liquid electrolytes, h-BN improves ionic mobility and suppresses side reactions, while in gel polymer electrolytes (GPEs), it enhances mechanical flexibility and thermal stability. SSEs benefit from h-BN's ability to suppress dendrites, reinforce mechanical strength, and optimize interfacial compatibility, making it a key enabler for next-generation battery technologies. Despite its promise, challenges such as dispersion uniformity, cost, and interfacial complexity must be addressed. Future directions, including the development of multifunctional architectures, dynamic electrolytes, and sustainable synthesis methods, are discussed to guide the integration of h-BN in emerging energy storage systems. This perspective article explores the multifunctional roles of h-BN, highlighting its contributions to enhancing ionic transport, thermal management, and interfacial stability. By presenting a comprehensive overview of h-BN's role in electrolytes, this work aims to inspire further research into its potential to revolutionize energy storage technologies.
Design and synthesis of thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen as potential MetAP (type II) inhibitors
(Elsevier, 2025) Yılmaz, Özgür; Biliz, Yağmur; Ayan, Sümeyra; Çevik, Özge; Karahasanoğlu, Müfide; Çotuker, Reyhan; Mert Şahin, Naz Mina; Gökkaya, Kübra; Gülyüz, Sevgi; Yelekçi, Kemal; Küçükgüzel, Ş. Güniz
In the present study, a range of novel thiosemicarbazides 4a-i and 1,2,4-triazoles 5a-i derived from ibuprofen, were synthesized. Structural elucidation of these synthesized compounds was performed utilizing a variety of spectroscopic methods, including FTIR, 1 H NMR, 13C NMR and HR-MS. The synthesized compounds were tested for cytotoxicity in five different cancer cell lines (cervical cancer (HeLa), human breast cancer (MCF-7), human gastric adenocarcinoma (MKN-45), human metastatic prostate cancer (PC3) and human glioblastoma (U87)). The compounds were compared with healthy cells (NIH-3T3) and the most effective compounds were determined by means of the selectivity index. Thiosemicarbazides derived form ibuprofen 4i and 4d showed anticancer activity, while 1,2,4-triazoles derived form ibuprofen 5b, 5c, 5d, 5e, 5h, 5g showed anticancer activity in HeLa, MCF-7, MKN-45, PC3 and U87 cells. To test the stability of the protein-drug complexes all 18 compounds 4a-i and 5a-i were docked into the active site of the MetAP2 enzyme In general, computational inhibition constants values were correlated with the experimental values. The dynamic behavior of MetAP2-inhibitor complexes was analyzed using all atoms Molecular Dynamic (MD) simulations for 200 ns duration. MD revealed that the drugs bind in the active center of MetAP2 with stable RMSD and RMSF. In conclusion, in-silico results and in-vitro studies suggests that thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen may be novel anticancer drug candidates for treating cervical, breast, prostate, gastric and glioblastoma. Compounds provided induction of apoptotic proteins in the cell by inhibiting MetAP2 enzyme. Furthermore, the potential antioxidant activities of the compounds were evaluated using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay. Among the compounds tested, 4a, 4b, 4e, 4f, 4h, and 4i exhibited values closely resembling the DPPH activity of the standards.

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