The role of extracellular vesicles in immunomodulation and pathogenesis of Leishmania and other protozoan infections
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
IntechOpen
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Extracellular vesicles (EVs) have lately emerged as crucial mediators in parasite infections. Recent research suggests that protozoan parasites, including Leishmania, employ EVs as transport vehicles to deliver biologically active effector molecules such as parasitic virulence factors to modulate the host immune system and their microenvironment. The immunomodulatory effects of EVs play an essential role in the formation and progression of parasitic diseases. The immunomodulatory strategies applied by EVs of protozoan origin have similarities to the development and progression of other infections or diseases such as cancer. In this chapter, we will provide recent insights into the role of EVs in host-pathogen interactions, intercellularcommunication, immunomodulation and pathogenesis of Leishmania and other protozoan parasites, including Plasmodium spp., Toxoplasma spp. and Trypanosoma spp. In addition, biologically inspired by the immunomodulation strategies of protozoan parasites, new immunotherapeutic models are being currently investigated to implement EVs more intensively in both therapy and diagnostics. Therefore, besides highlighting the role of EVs in protozoan infections, this chapter sheds light briefly on new immunotherapeutic approaches utilizing the strategies of protozoan EVs in medicine.
Açıklama
Anahtar Kelimeler
Extracellular Vesicles, Immunomodulation, Pathogenesis, Protozoan, Leishmania, Infectious Disease
Kaynak
Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
İşlek, Z., Bozkurt, B. T., Üçışık, M. H. & Şahin, F. (2022). The role of extracellular vesicles in immunomodulation and pathogenesis of Leishmania and other protozoan infections. M. K. Paul (Ed.), Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy içinde (pp. 165-188). London: IntechOpen. http://dx.doi.org/10.5772/intechopen.94822
