The role of extracellular vesicles in immunomodulation and pathogenesis of Leishmania and other protozoan infections

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dc.authorid0000-0003-4789-9095en_US
dc.authorscopusid57212405586en_US
dc.authorwosidAER-3170-2022en_US
dc.contributor.authorİşlek, Zeynep
dc.contributor.authorBozkurt, Batuhan Turhan
dc.contributor.authorÜçışık, Mehmet Hikmet
dc.contributor.authorŞahin, Fikrettin
dc.contributor.editorPaul, Manash K.
dc.date.accessioned2023-02-22T07:34:53Z
dc.date.available2023-02-22T07:34:53Z
dc.date.issued2022en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractExtracellular vesicles (EVs) have lately emerged as crucial mediators in parasite infections. Recent research suggests that protozoan parasites, including Leishmania, employ EVs as transport vehicles to deliver biologically active effector molecules such as parasitic virulence factors to modulate the host immune system and their microenvironment. The immunomodulatory effects of EVs play an essential role in the formation and progression of parasitic diseases. The immunomodulatory strategies applied by EVs of protozoan origin have similarities to the development and progression of other infections or diseases such as cancer. In this chapter, we will provide recent insights into the role of EVs in host-pathogen interactions, intercellularcommunication, immunomodulation and pathogenesis of Leishmania and other protozoan parasites, including Plasmodium spp., Toxoplasma spp. and Trypanosoma spp. In addition, biologically inspired by the immunomodulation strategies of protozoan parasites, new immunotherapeutic models are being currently investigated to implement EVs more intensively in both therapy and diagnostics. Therefore, besides highlighting the role of EVs in protozoan infections, this chapter sheds light briefly on new immunotherapeutic approaches utilizing the strategies of protozoan EVs in medicine.en_US
dc.identifier.citationİşlek, Z., Bozkurt, B. T., Üçışık, M. H. & Şahin, F. (2022). The role of extracellular vesicles in immunomodulation and pathogenesis of Leishmania and other protozoan infections. M. K. Paul (Ed.), Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy içinde (pp. 165-188). London: IntechOpen. http://dx.doi.org/10.5772/intechopen.94822en_US
dc.identifier.doi10.5772/intechopen.94822en_US
dc.identifier.endpage188en_US
dc.identifier.isbn9781803550541
dc.identifier.isbn9781803550558
dc.identifier.isbn9781803550565
dc.identifier.issn2631-8261
dc.identifier.startpage165en_US
dc.identifier.urihttp://dx.doi.org/10.5772/intechopen.94822
dc.identifier.urihttps://hdl.handle.net/20.500.13055/397
dc.institutionauthorİşlek, Zeynep
dc.language.isoenen_US
dc.publisherIntechOpenen_US
dc.relation.ispartofExtracellular Vesicles - Role in Diseases, Pathogenesis and Therapyen_US
dc.relation.publicationcategoryKitap Bölümü - Ulusalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExtracellular Vesiclesen_US
dc.subjectImmunomodulationen_US
dc.subjectPathogenesisen_US
dc.subjectProtozoanen_US
dc.subjectLeishmaniaen_US
dc.subjectInfectious Diseaseen_US
dc.titleThe role of extracellular vesicles in immunomodulation and pathogenesis of Leishmania and other protozoan infectionsen_US
dc.typeBook Chapteren_US
dspace.entity.typePublication

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