The effects of anthocyanin consumption on functional connectivity in dementia and type 2 diabetes mellitus

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dc.authorid0000-0001-8552-4994
dc.authorid0000-0001-6304-2556
dc.authorid0009-0009-6984-0386
dc.authorid0000-0002-7855-7779
dc.contributor.authorMüdüroğlu Kırmızıbekmez, Aynur
dc.contributor.authorÖnder, Alparslan
dc.contributor.authorÖzdemir, Mustafa Yasir
dc.contributor.authorYüksel Eryiğit, Önder
dc.contributor.authorKara, İhsan
dc.date.accessioned2026-05-06T11:42:32Z
dc.date.available2026-05-06T11:42:32Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractThis study investigates the effects of 12 weeks of anthocyanin consumption on brain function in individuals with Dementia with Type 2 Diabetes Mellitus (T2DM) and Dementia alone. Two groups of individuals: 12 participants with T2DM comorbid with dementia and 31 participants with dementia alone. EEG recordings were collected at baseline, before the start of the study, and after 12 weeks of anthocyanin consumption. During the study period, participants consumed 300 mg of anthocyanins daily. EEG recordings were conducted using a 21-channel gel EEG cap following the 10–20 system at a sampling rate of 500 Hz. EEG signals were divided into seven frequency bands, and the Imaginary Part of Coherence (iCOH) metric, which reduces volume conduction effects, was used to evaluate functional connectivity. Within-group analyses were performed using the Wilcoxon signed-rank test, and between-group comparisons were conducted using the Mann-Whitney U test, both implemented in Python. This study demonstrates that 12 weeks of anthocyanin supplementation positively impacts neural network ef ficiency and functional connectivity in both the Cognitive Impairment (CI) group and the Type 2 Diabetes Mellitus with Cognitive Impairments (T2DMwCI) group. Significant improvements were observed in iCOH, GE, and LE metrics across delta, theta, beta, and gamma frequency bands, indicating enhanced information pro cessing and potential compensatory mechanisms. These findings highlight the neuroprotective properties of anthocyanins, suggesting their potential to mitigate cognitive decline associated with T2DM and dementia. As a result, it supports the idea that anthocyanins are a potential dietary intervention for mitigating cognitive decline, though further research is needed to validate and expand these results.
dc.identifier.citationMüdüroğlu Kırmızıbekmez, A., Önder, A., Özdemir, M. Y., Yüksel Eryiğit, Ö., & Kara, İ. (2026). The effects of anthocyanin consumption on functional connectivity in dementia and type 2 diabetes mellitus. Pharmacological Research - Natural Products, 10, pp. 1-8. https://doi.org/10.1016/j.prenap.2025.100486
dc.identifier.doi10.1016/j.prenap.2025.100486
dc.identifier.endpage8
dc.identifier.issn2950-1997
dc.identifier.scopus2-s2.0-105027189456
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1016/j.prenap.2025.100486
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1470
dc.identifier.volume10
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYüksel Eryiğit, Önder
dc.institutionauthorid0000-0002-7855-7779
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofPharmacological Research - Natural Products
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectElectroencephalography
dc.subjectAnthocyanin
dc.subjectDementia
dc.subjectType II Diabetes
dc.titleThe effects of anthocyanin consumption on functional connectivity in dementia and type 2 diabetes mellitus
dc.typeArticle
dspace.entity.typePublication

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