Preparation and in vitro characterisation of nanofibers for enhancing the water solubility of poorly soluble drugs

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dc.authorid0009-0000-3782-4036
dc.authorid0000-0002-8658-3723
dc.authorid0000-0002-8449-548X
dc.authorid0000-0001-5724-9809
dc.authorid0000-0002-9110-3704
dc.contributor.authorKaramürsel, Elif
dc.contributor.authorUzel, Egemen
dc.contributor.authorAydilek, Neriman
dc.contributor.authorDurgun, Meltem Ezgi
dc.contributor.authorÖzsoy, Yıldız
dc.date.accessioned2026-02-20T15:59:41Z
dc.date.available2026-02-20T15:59:41Z
dc.date.issued2025
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractBackground and Aims: As the drug discoveries of the modern century have led to a rapid increase in the number of new drug candidates with low water solubility, nanofiber drug delivery systems have become a promising technology to increase the water solubility of drugs with a high surface-to-volume ratio. In this study, we aimed to prepare a nanofiber of a molecule with low water solubility and investigate its changing solubility properties. Methods: Three nanofiber dosage forms containing olanzapine (OLZ) active substance were developed by the electrospinning method using polyvinyl alcohol (PVA) polymer. Drug loading efficiency, zeta potential determination, electrical conductivity, rheology, field emission scanning electron microscopy (FESEM), Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) analyses were performed to evaluate the in vitro characterisation of the formulations. The solubility profile of the optimised formulations in pH 7.4 phosphate buffer was evaluated. The stability of optimised formulations was evaluated in terms of physical properties (colour, shape, weight, diameter, and thickness) and drug amount for 35 days. Results: It was determined that the electrospinning property of the nanofiber preparation solution increased with the addition of ethanol to the polymer solvent medium. The active substance distribution in the nanofiber layer was more homogeneous in the N78 and N79 coded formulations with high zeta potential values compared to N69. Contrary to the homogeneous distribution problem, the loading efficiency of the N69-coded formulation containing chloroform (~29%) was higher than that of N79 (~9.8%). A 24-h solubility study in pH 7.4 phosphate buffer of the N78-coded formulation, which has an active ingredient loading efficiency of ~80.4%, confirmed the increased solubility of OLZ in water in the nanofiber drug delivery system. Conclusion: Further studies are needed to convert these model formulations into final drug products.
dc.identifier.citationKaramürsel, E., Uzel, E., Aydilek, N., Durgun, M. E., & Özsoy, Y. (2025). Preparation and in vitro characterisation of nanofibers for enhancing the water solubility of poorly soluble drugs. İstanbul Journal of Pharmacy, 55(3), pp. 318-331. https://doi.org/10.26650/İstanbulJPharm.2025.1635537
dc.identifier.doi10.26650/İstanbulJPharm.2025.1635537
dc.identifier.endpage331
dc.identifier.issn2548-0731
dc.identifier.issn2587-2087
dc.identifier.issue3
dc.identifier.startpage318
dc.identifier.urihttps://doi.org/10.26650/İstanbulJPharm.2025.1635537
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1339
dc.identifier.volume55
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorDurgun, Meltem Ezgi
dc.institutionauthorid0000-0001-5724-9809
dc.language.isoen
dc.publisherİstanbul University Press
dc.relation.ispartofİstanbul Journal of Pharmacy
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBioavailability
dc.subjectNanofibers
dc.subjectOlanzapine
dc.subjectSolubility
dc.titlePreparation and in vitro characterisation of nanofibers for enhancing the water solubility of poorly soluble drugs
dc.typeArticle
dspace.entity.typePublication

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