Fibrosis changes following viral clearance and its relation to HCC

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dc.authorid0000-0002-8909-2102en_US
dc.authorscopusid56035868800en_US
dc.authorwosidK-1194-2018en_US
dc.contributor.authorYılmaz, Nevin
dc.contributor.authorYılmaz, Uğur Eser
dc.contributor.authorTanrıverdi, Özgür
dc.contributor.authorÖrmeci, Necati
dc.date.accessioned2023-04-03T10:55:09Z
dc.date.available2023-04-03T10:55:09Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractGlobally, about 290 000 people died from hepatitis C (HCV) in 2019, mostly from cirrhosis and hepatocellular carcinoma (HCC). Less than a decade, direct-acting antivirals (DAAs) replaced interferon-based therapies in treatment protocols and sustained virologic response (SVR) rates exceeded 95%. However, it is not clear yet whether HCV eradication by DAAs can reverse fibrosis or cirrhosis substantially, reduce the risk of developing HCC in the long term. In this review was aimed to summarizes the evidence for reversibility or progression of fibrosis following HCV clearance by DAAs, subsequently its impact on developing de nova HCC. For this purpose, cohorts in which patients achieved SVR, have paired liver stiffness measurements obtained by transient elastography were reviewed and results discussed.en_US
dc.identifier.citationYılmaz, N., Yılmaz, U. E., Tanrıverdi, Ö., & Örmeci, N. (2022). Fibrosis changes following viral clearance and its relation to HCC. Academic Journal of Gastroenterology & Hepatology (AJGH), 3(3), pp. 1-5. https://doi.org/10.33552/AJGH.2022.03.000564en_US
dc.identifier.doi10.33552/AJGH.2022.03.000564en_US
dc.identifier.endpage5en_US
dc.identifier.issn2692-5400
dc.identifier.issue3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.33552/AJGH.2022.03.000564
dc.identifier.urihttps://hdl.handle.net/20.500.13055/437
dc.identifier.volume3en_US
dc.institutionauthorÖrmeci, Necati
dc.language.isoenen_US
dc.publisherIris Publishersen_US
dc.relation.ispartofAcademic Journal of Gastroenterology & Hepatology (AJGH)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHCV Infectionen_US
dc.subjectHepatocellular Carcinomaen_US
dc.subjectFibrosisen_US
dc.subjectSustain Virologic Responseen_US
dc.subjectDirect-Acting Antiviralsen_US
dc.subjectLiver Stiffnessen_US
dc.titleFibrosis changes following viral clearance and its relation to HCCen_US
dc.typeArticleen_US
dspace.entity.typePublication

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