Dahili Tıp Bilimleri Bölümü Koleksiyonu

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https://hdl.handle.net/20.500.13055/58

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Evaluation of management strategies for viral upper respiratory tract infections among pediatricians in Türkiye
(Taylor & Francis, 2025) Yıldız, İsmail; Gönüllü, Erdem; Uçkun, Utkucan; Kandemir, İbrahim; Soysal, Ahmet; Karaböcüoğlu, Metin
Background: To evaluate how pediatricians manage viral upper respiratory tract infections (URTIs) in children and their tendencies about the viral URTIs approaches. Materials and Methods: This study was conducted among pediatricians who participated in a descriptive cross-sectional survey. The survey included pediatricians who were willing to participate and who completed the survey forms between June 2023 and February 2024. The survey gathered data on the demographic characteristics of the pediatricians, as well as their diagnostic and treatment approaches for viral URTIs. Demographic data included the physicians’ gender, age, academic title, province of duty, institution of practice, and duration of experience in pediatrics. Results: This study involved 203 pediatricians. The diagnosis of viral URTI based on clinical findings had a negative correlation with pediatricians’ work experience (OR: 0.96 per year) and was more common among those working in private settings (OR: 0.38). Use of medications for symptomatic cough treatment was 2.72 times higher among pediatricians in private practice. Herbal supplement use was more common among pediatricians in private practice (p = 0.021) and those with ≥10 years of experience (p = 0.010). Systemic decongestant use was more frequent among pediatricians without an academic title (p = 0.030). Pelargonium sidoides root extract was used more often by pediatricians in private practice (p = 0.003), and they also preferred honey-containing supplements more frequently (p < 0.05). There was a negative correlation between experience in pediatric practice and multivitamins and minerals prescriptions for prevention of viral URTIs (OR: 0.97 for each year). Conclusion: Pediatricians in private settings and with more experience tend not to make a diagnosis of viral URTIs solely based on physical examination. Pediatricians working in private settings focus more on treatments that relieve cough symptoms. A viral URTI diagnostic and treatment algorithm with proven validity will help physicians in clinical diagnosis and treatment.
Effect of slow versus rapid advancement of enteral feeding on intestinal oxygenation in preterm infants
(MDPI Publishing, 2025) Özdemir, Hülya; Kersin, Sinem Gülcan; Can Buker, Halime Sema; Çetinkaya, Merih; Kandemir, İbrahim; Memişoğlu, Aslı; Bilgen, Hülya Selva
Background/Objectives: The optimal rate of enteral feeding advancement in preterm infants remains uncertain despite decades of clinical research. This uncertainty arises from concerns that rapid feeding progression may increase the risk of feeding intolerance and necrotizing enterocolitis (NEC), two major causes of morbidity and mortality in this population. The feeding rate may also influence intestinal oxygenation due to mesen teric hemodynamic changes during feeding. This study aimed to evaluate whether the rate of enteral feeding advancement (slow vs. rapid) affects intestinal oxygenation and its association with feeding intolerance (FI) or necrotizing enterocolitis in very low birth weight preterm infants. Methods: This prospective, randomized, two-center study in cluded infants born at 28–32 weeks of gestation. Group 1 received slow advancement (20 mL/kg/day) and Group 2 rapid advancement (30 mL/kg/day) of enteral feeds. Splanchnic (srSO2) and cerebral (crSO2) oxygenation were monitored daily using the FDA approved INVOS NIRS device during feeding periods (08:00–16:00). Monitoring was per formed during minimal enteral nutrition (Phase 1), advancement phases (Phase 2), and for two days after achieving full enteral feeding (Phase 3). The splanchnic-to-cerebral oxygena tion ratio (SCOR) was also calculated. Percentage changes in srSO2 and SCOR during and after feeding were calculated from baseline (prefeeding) values and analyzed. Results: Sixty infants were enrolled. Mean gestational age and birth weight were 29.76 ± 1.33 weeks and 1375.05 ± 271.19 g, respectively. Group 2 achieved full enteral feeding significantly earlier (p = 0.001), with no other demographic differences between groups. No cases of NEC were observed. Feeding intolerance occurred in 14 infants (23.3%): 8 in Group 1 and 6 in Group 2 (p = 0.192). Both groups exhibited increased srSO2 and SCOR during feeding; however, the between-group differences were not statistically significant (Phase 2 srSO2 and SCOR: p = 0.07, 0.08; Phase 3 srSO2 and SCOR: p = 0.069, 0.071). However, the percentage change from baseline in srSO2 and SCOR during and after feeding was significantly greater in Group 2 during the advancement and full enteral feeding phases (Phase 2 srSO2 and SCOR: p = 0.03, 0.022; Phase 3 srSO2 and SCOR: p = 0.015, 0.048). Infants with feeding intolerance demonstrated significantly lower srSO2 and SCOR values compared to tolerant infants, and this reduction persisted even after reaching full enteral feeding. ROC analysis sug gested gestational age < 30 weeks, birth weight < 1180 g, srSO2 < 52, and SCOR < 0.6 were associated with feeding intolerance. Conclusions: Intermittent bolus feeding increased intestinal oxygenation, with a more pronounced effect in the rapid advancement group. No difference in gastrointestinal adverse outcomes was observed between groups. Lower in testinal oxygenation was associated with feeding intolerance, and the suggested predictive criteria may help guide individualized feeding strategies.
The impact of infant positioning on pain and early neonatal morbidities
(Elsevier, 2025) Kersin, Sinem Gülcan; Kandemir, İbrahim; Cıbır, Seval; Özdemir, Hülya; Memişoğlu, Aslı; Bilgen, Hülya Selva
Purpose: To investigate whether appropriate positioning, assessed using the Infant Positioning Assessment Tool (IPAT), is associated with lower pain scores and reduced incidence of early neonatal morbidities in the first week of life in premature infants. Methods: This retrospective observational study was conducted at a single center. The pre-implementation (non IPAT) group was assessed using the NPASS (Neonatal Pain, Agitation, and Sedation Scale) alone, whereas the post-implementation (IPAT) group was evaluated using both the NPASS and the IPAT. Results: The IPAT group consisted of 77 infants, and the non-IPAT group consisted of 40 infants. The mean gestational age and weight of the cases were 29.9 ± 1.2 weeks and 1350 ± 234 g, respectively. Pain scores increased in infants with intraventricular hemorrhage (IVH) (days 3 and 7) and necrotizing enterocolitis (NEC) (days 4 and 5), but decreased with IPAT use on days 5–7. IPAT scores showed a moderate negative correlation with IVH on days 1 and 6, and a strong negative correlation with NEC on day 7. Conclusion: Higher positioning quality is associated with lower pain scores and potentially fewer early morbid ities in preterm infants during the first week of life. Optimal positioning using the IPAT will help establish nursing standards and increase awareness among primary caregivers.
Diffuse alveolar hemorrhage induced by epileptic seizure
(Wiley, 2025) Talibov, Tural; İnci, Meltem; Ismayilov, Rashad; Bebek, Nerses
Diffuse alveolar hemorrhage (DAH) is a rare but life-threatening complication of generalized tonic–clonic seizures. We describe a 28-year-old woman with no prior seizure history who experienced three consecutive generalized tonic–clonic seizures, followed by acute hemoptysis and dyspnea. Imaging confirmed diffuse alveolar hemorrhage, which responded rapidly to corticosteroid therapy. Seizure-induced DAH is an uncommon and underrecognized condition. This case underscores the importance of considering DAH in patients presenting with respiratory symptoms following seizures, even in the absence of underlying systemic disease.
A case of tongue twisting during screening of STN DBS for parkinson’s disease: A unique form of pyramidal tract activation
(Turkish Neurosurgical Society, 2025) Değirmenci, Yıldız; Akram, Harith; Dayal, Viswas; Zrinzo, Ludvic; Hariz, Marwan; Limousin, Patricia
Subthalamic nucleus deep brain stimulation (STN-DBS) is a safe and effective therapy for Parkinson´s disease (PD) in selected patients. However, various side effects such as paraesthesia, diplopia, ataxia, worsened akinesia, emotional changes, dysarthria, and muscle contractions can occur due to the current spread to the adjacent structures during the STN-DBS programming sessions. Muscle contractions result from the corticospinal and corticobulbar side effects, which can manifest due to the current spread to the pyramidal tract during DBS programming. Here, we report a case of tongue-twisting movement as a unique corticobulbar side effect of the STN-DBS programming in a patient with PD.
A natural therapeutic approach to fibrocystic breast disease: Antiproliferative effects of phenolic cocktail and metformin on a fibrocystic breast cell line model
(Wiley, 2025) Sag, Matej; Pehlevan Karabıyık, Funda; Ceviz Çubukçuoğlu, Ayşe Begüm; Aydoğan, Çağatay; Malikova, Fidan; Yalım, D.; Özkara, Gamze Akın; Öztürk, Özmen
A natural therapeutic approach to fibrocystic breast disease: antiproliferative effects of phenolic cocktail and metformin on a fibrocystic breast cell line model.
Effects of a polyphenolic chemical mixture on the apoptotis pathway of a triple negative breast cancer cell line
(Wiley, 2025) Eronat, Allison Pınar; Ceviz Çubukçuoğlu, Ayşe Begüm; Özkara, Gamze Akın; Yılmaz Aydoğan, Hülya; Öztürk, Özmen
Effects of a polyphenolic chemical mixture on the apoptotis pathway of a triple negative breast cancer cell line.
Comparative effects of propolis and polyphenolic cocktail (PFK5120) on EGFR signaling in MCF-7 hormone positive breast cancer cell line
(Wiley, 2025) Çelik, İrem Nur; Aydoğan, Çağatay; Ceviz Çubukçuoğlu, Ayşe Begüm; Tomaç, Hakan; Öztürk, T.; Yılmaz Aydoğan, Hülya; Öztürk, Özmen
Comparative effects of propolis and polyphenolic cocktail (PFK5120) on EGFR signaling in MCF-7 hormone positive breast cancer cell line.
Cytotoxic effects of polyphenolic cocktail (PFK5120), salicylic acid and indole-3-carbinol combinations on gastric adenocarcinoma cell line
(Wiley, 2025) Yalım, Dikmen; Çelik, İrem Nur; Ceviz Çubukçuoğlu, Ayşe Begüm; Aydoğan, Çağatay; Yılmaz Aydoğan, Hülya; Öztürk, T.; Öztürk, Özmen
Cytotoxic effects of polyphenolic cocktail (PFK5120), salicylic acid and indole-3-carbinol combinations on gastric adenocarcinoma cell line.
Polyphenolic cocktail (PFK5120) treatment of breast cancer cell lines: superior anti-carcinogenic and anti-metastatic effects to doxorubicin
(Wiley, 2025) Özkara, Gamze Akın; Ceviz Çubukçuoğlu, Ayşe Begüm; Çelik, İrem Nur; Korkmaz, Nur Damla; Öztürk, Özmen; Yılmaz Aydoğan, Hülya
Polyphenolic cocktail (PFK5120) treatment of breast cancer cell lines: superior anti-carcinogenic and anti-metastatic effects to doxorubicin
Molecular perspective on gemcitabine resistance in PANC-1 and PANC-1GemR pancreatic cancer cells: The potential role of polyphenolic cocktail (PFK5120) in overcoming chemoresistance
(Wiley, 2025) Ceviz Çubukçuoğlu, Ayşe Begüm; Aydoğan, Çağatay; İbrahimova, Gülnar; Yılmaz Aydoğan, Hülya; Öztürk, Özmen
Molecular perspective on gemcitabine resistance in PANC-1 and PANC-1GemR pancreatic cancer cells: The potential role of polyphenolic cocktail (PFK5120) in overcoming chemoresistance.
Safety monitoring of colistin therapy in critically ıll neonates with late-onset sepsis: A retrospective observational study
(British Pharmacological Society, 2025) Acargök, Baran Cengiz; Yaman, Akan; Rzayev, Turkay; Jalalzada, Nazlı; Kandemir, İbrahim; Memişoğlu, Aslı; Bilgen, Hülya Selva
This study aimed to evaluate the safety of colistin therapy by monitoring renal function and electrolyte levels in critically ill neonates with late-onset sepsis (LOS) hospitalized in the neonatal intensive care unit (NICU) between 2015 and 2021. This ret rospective case–control study included 58 critically ill neonates treated with colistin for late-onset sepsis and 22 control neonates with late-onset sepsis who did not receive colistin. Data were analyzed to compare patient outcomes, microbiological profiles, and side effects of treatment. Statistical analyses were performed using repeated-measures ANOVA and Bayesian calculations to evaluate serum creatinine levels and biochemical parameters over time. Serum creatinine levels showed similar alterations within the first 7days of colistin treatment with moderate evidence. However, serum magnesium and sodium levels were lower on the 7th day in the colistin-treated group compared with the control group. Colistin therapy in critically ill neonates with late-onset sepsis appears to be a viable treatment option with an acceptable short-term safety profile. These findings emphasize the importance of routine monitoring of renal function and electrolyte levels during colistin use in neonatal intensive care to minimize potential complications.
Reflectance confocal microscopy for differentiating clear cell acanthoma from squamous cell carcinoma in situ
(Galenos Publishing House, 2025) Oraloğlu, Göktürk; Duman, Nilay; Yaman, Banu; Karaarslan, Işıl
Background and Design: There are few reports on the in vivo reflectance confocal microscopy (RCM) features of clear cell acanthoma (CCA). This study aimed to evaluate the diagnostic ability of RCM in CCAs that are difficult to diagnose clinically and to compare the RCM findings with those observed in squamous cell carcinoma in situ (SCCIS) lesions, which exhibit similar clinical morphology. Materials and Methods:We searched our database and identified three cases of CCA with atypical features and three cases of SCCIS with common morphological features. We described the clinical, dermoscopic, RCM, and histopathological characteristics of these cases. Results: Both lesion groups showed prominent epidermal hyperplasia on RCM; however, atypia in epidermal cells in CCAs was not as pronounced as that in SCCISs. The general architecture was preserved in the CCAs. In SCCISs, epidermal basal cells were increased in size, and prominent pleomorphism and atypia were observed in the full-thickness epidermis, whereas basal cells in CCAs were normal in pattern and appearance. Conclusion: We suggest that differentiating CCA from SCCIS on RCM is possible, even in atypical cases, by careful evaluation of the general architecture of the tumor and determination of the degree of epidermal disarray, nuclear features of the epidermal cells, presence of uniformity or pleomorphism of the epidermal cells, and features of the basal cells. A comparison of normal skin and tumor areas may also help in better evaluation.
Investigation of the association between nitric oxide synthase gene variants and NAFLD in adolescents with obesity
(De Gruyter, 2025) Hasanoğlu Sayın, Sevde; Kandemir, İbrahim; Oyacı, Yasemin; Khudiyeva, Shahri; Şahin, Memduh; Yetim Şahin, Aylin; Pehlivan, Sacide
Objectives: The present study aimed to investigate whether nitric oxide synthase (NOS) enzyme gene variants (iNOS rs1060826, eNOS rs1799983, eNOS 27-bp VNTR) play a role in the etiopathogenesis of nonalcoholic fatty liver (NAFLD) in adolescents. Methods: This cross-sectional study was conducted with obese adolescents [body mass index (BMI) standard devia tion score (SDS) ≥2] aged 10–19 years (104 individuals) and age- and sex-matched healthy individuals (64 individuals) whose presence of NAFLD was determined by ultrasound. The iNOS rs1060826 and eNOS rs1799983 variants were performed by Polymerase Chain Reaction-Restriction Frag ment Length Polymorphism (PCR-RFLP) method, and the eNOS 27-bp VNTR variant was analyzed using the PCR method. The genotypes detected were compared between the patient group and the healthy controls and with the clinical parameters of the patients. Results: iNOS rs1060826 and eNOS rs1799983 were inde pendent of obesity, whereas eNOS 27-bp VNTR was inde pendent of NAFLD. However, in the obese group, especially in those with NAFLD (+), the iNOS rs1060826 GG genotype was found to be associated with lower diastolic blood pres sure (DBP) (p=0.011). Compared with the clinical parameters, insulin resistance (HOMA-IR) was higher in those carrying the eNOS rs1799983 gene variant-TT genotype in the NAFLD (+) group (p=0.051). Conclusions: While the three functional gene variants of the NOS enzyme did not show a significant difference in terms of genotype between patients and healthy controls, it was determined that both the iNOS rs1060826 gene variant GG allele was associated with low DBP and HOMA-IR may be higher in those carrying the eNOS rs1799983 gene variant TT genotype in NAFLD (+) patients. The iNOS rs1060826 poly morphism is a potentially important genetic variant that may influence DBP regulation through its effects on nitric oxide production.
Dermoscopy-guided surveillance in xeroderma pigmentosum: A retrospective analysis
(Galenos Publishing House, 2025) Oraloğlu, Göktürk; Duman, Nilay; Yaman, Banu; Akalın, Taner; Karaarslan, Işıl
Aim: Xeroderma pigmentosum (XP) is a life-threatening disease characterized by high rates of skin cancers. Therefore, it is important to establish key guidelines for the follow-up of these patients to detect skin cancers, particularly melanoma, at an early stage. Materials and Methods: This is a retrospective study that includes the analysis of the follow-up findings and medical records of XP patients who were followed up with whole-body skin examination, dermoscopic examination, and whole-body photographing between 2003 and 2021 in the Dermato Oncology unit of Ege University Department of Dermatology. Results: Of the 19 patients, 10 were male and 9 were female. The youngest patient was 5 years old, while the oldest patient was 64 years old. A total of 234 lesions were excised from these patients. Seventeen melanomas were excised, including 11 in situ, with a Breslow thickness of less than 1 mm. The highest Breslow scores belong to patients who missed their appointments or did not receive follow-up care previously. Conclusion: It was observed that regular full-body skin examinations, whole-body photography, and dermoscopic monitoring performed at 3-month intervals in XP patients are helpful in detecting skin malignancies at an early stage and preventing unnecessary excisions.
Red cell distribution width-to-platelet ratio and other hematological markers as early predictors of bronchopulmonary dysplasia in preterm infants
(MDPI Publishing, 2025) Arcagök, Baran Cengiz; Kandemir, İbrahim
Background/Objectives: Bronchopulmonary dysplasia (BPD) frequently affects preterm infants and is associated with lasting morbidity. Early prediction remains challenging. The present study investigated whether hematological inflammatory markers—platelet-to-lymphocyte ratio (PLR), red cell distribution width (RDW), and red cell distribution width-to-platelet ratio (RPR)—can predict the development of BPD in preterm neonates. Methods: We performed a retrospective cohort study involving 100 infants born at less than 32 weeks’ gestation. Complete blood count (CBC) parameters were collected at birth, 72 h, 1 week, and 2 weeks of life. Associations between PLR, RDW, RPR, and BPD development were analyzed. Multivariate regression and receiver operating characteristic (ROC) curve analyses were carried out to evaluate the predictive performance of the markers. Results: Forty-nine percent of infants developed BPD. Those with BPD had significantly higher RDW, PLR, and RPR values, and lower lymphocyte and platelet counts at various time points. Gestational age, respiratory distress syndrome, and hematological indices independently predicted BPD. ROC analysis showed that RDW ≥ 67.2 and PLR ≥ 98.13 at 72 h, and RPR ≥ 0.3 at 7 and 14 days had good predictive performance. A combined scoring system, including clinical and hematological markers, achieved high sensitivity and specificity. Conclusions: Hematological inflammatory markers, especially RPR, PLR, and RDW, derived from routine CBC tests may serve as accessible, cost-effective tools for early BPD risk stratification in preterm infants. Additional studies are needed to confirm these results and better define their relevance in clinical practice.
Diagnostic value of leukocyte count, c-reactive protein, and procalcitonin in pediatric liver transplant patients during the first week postoperative: A longitudinal study from a tertiary center and a new diagnostic method for predicting systemic infection
(MDPI Publishing, 2025) Önal, Zerrin; Türkmen, Elif; Demirkol, Demet; Leblebici, Uğur Can; Kandemir, İbrahim; Yılmaz, Tuğçe Göksu; Torun, Selda Hançerli; Ekiz, Feza; Özden, Ilgın; Durmaz, Özlem
Background/Objectives: Infection is a major complication during the early postoperative period following pediatric liver transplantation (LT). Prompt diagnosis and treatment are essential to prevent death. We aimed to assess the diagnostic value of procalcitonin (PCT), white blood cell count (WBC), and C-reactive protein (CRP) levels for detecting bacterial infection and SIRS within the first week after LT. Methods: Demographic data, vital signs, laboratory results (PCT, CRP, WBC), and culture findings on the 1st, 4th, and 7th days between January 2010 and 2024 were collected retrospectively. Results: The study included 88 patients. Seventy-two percent had cirrhotic liver disease. SIRS was present in 17% (n = 15), and bacterial growth was detected in 20% (n = 18). Bacterial growth was found in 80% of patients with SIRS (n = 12/15) and in 8% of SIRS-negative patients (n = 6/73). PCT levels were significantly elevated on days 1, 4, and 7, and CRP lev els on days 4 and 7 in patients with SIRS. PCT elevation was significant on days 1, 4, and 7, while WBC increase was noted on day 7 in patients with bacterial growth. Body temperature ≥ 37.1 ◦C and PCT ≥ 5.1 ng/dL on the first day together showed a sensitivity of 72.2% and specificity of 84.3% for bacterial growth. Similarly, body temperature ≥ 37.1 ◦C and PCT ≥ 9.2 ng/dL on the first day yielded 73% sensitivity and 95% specificity for diagnosing SIRS. Cirrhotic patients exhibited limited or no WBC response to bacterial growth. Conclusions: PCT, CRP, and WBC alone are insufficient for diagnosing infection. Combined assessment of body temperature changes and PCT elevation may serve as more accurate indicators. Nonetheless, close monitoring of culture results and clinical signs, with serial physical exams, can aid timely infection management or prevent unnecessary antibiotic adjustments.
Management of acute variceal bleeding: Updated APASL guidelines
(Springer Nature Link, 2025) Lesmana, Cosmas Rinaldi Adithya; Shukla, Akash; Kumar, Ashish; Shalimar; Qi, Xiaolong; Gani, Rino Alvani; Dökmeci, Abdul Kadir; Örmeci, Necati; Sarin, Shiv Kumar
Acute variceal bleeding (AVB) is a common life-threatening complication of portal hypertension (PHT), having a six-week mortality of 10%-20%. Major advances in the hemodynamic management, risk stratification, pharmacotherapy, endoscopy techniques, hemostatic devices and radiological interventions have led to improved management and outcome of AVB patients in the recent past. Therefore, the APASL Portal Hypertension Working Party, chose a panel of experts, primarily from the Asia–Pacific region, to identify important developments and controversial areas in the field of AVB. They discussed through a pre-defined and structured process, advances in the field and proposed updates to the previous APASL AVB guidelines. These included emphasis on safe transportation, defining time frames for AVB episodes and re-bleeding, reporting of clinical outcomes, optimizing early intervention strategies, pharmacotherapy, medical management, endoscopic therapies, and salvage modalities, including TIPS and self-expanding metal stents. The current updates also cover variceal bleeding in special populations and situations, the skill sets required for managing AVB patients, and the research priorities in the field. The updated guidelines are based on the latest evidence and incorporate emerging trends to provide a contemporary template for management of AVB in both patients with cirrhosis and non-cirrhotic portal hypertension.
MAFLD: A comprehensive review of the link between metabolic dysfunction and cardiovascular risk
(Taylor & Francis, 2025) M. Mostafa, Alaa; Pan, Ziyan; Yu, Ming-Lung; Örmeci, Necati; Fouad, Yasser; Eslam, Mohammed
Metabolic dysfunction-associated fatty liver disease (MAFLD) affects over 30% of the global population. It is a multisystem condition with a strong association with cardiovascular disease (CVD), the leading cause of mortality worldwide. Key shared mechanisms, including insulin resistance, systemic inflammation, oxidative stress, and genetic predisposition, couple MAFLD with increased risks of coronary artery disease, ischemic heart disease, and heart failure. Early detection via non-invasive imaging and biomarkers is crucial for effective risk stratification. Management strategies emphasize lifestyle modifications and the development of targeted pharmacotherapies addressing metabolic and inflammatory pathways. Understanding the interconnected pathogenic mechanisms facilitates personalized interventions to reduce morbidity and improve long-term outcomes. A multidisciplinary approach remains essential to prevent and manage the cardiovascular implications of MAFLD.
Evaluation of posterior segment changes in pediatric asthma patients with and without inhaled corticosteroid therapy
(Springer Nature, 2025) Kıvrak, Ulviye; Çiçek, Fatih; Köle, Mehmet Tolga; Kaya Adaş, Büşra; Kandemir, İbrahim
This study aimed to evaluate and compare changes in the posterior segment of pediatric asthma patients, potentially associated with asthma or inhaled corticosteroids. A retrospective analysis was conducted on children aged 7–17 diagnosed with atopic asthma. The participants were categorized into groups: Group 1 (no inhaled corticosteroids) and Group 2 (inhaled corticosteroid treatment). A control group of healthy children was also included. Demographic data, clinical findings, and laboratory results (e.g., eosinophil count, IgE, CRP levels) were collected. Optical coherence tomography (OCT) and OCT angiography (OCTA) were used to measure posterior segment parameters. Asthma patients demonstrated a statistically significant reduction in subfoveal choroidal thickness, the superficial capillary plexus in the superior and nasal quadrants, the choriocapillaris in the foveal quadrant, and the peripapillary vascular density in the inferior and superior quadrants compared to controls. Inflammation markers such as eosinophil count and CRP showed significant correlations with changes in vascular density. Asthma, as a chronic inflammatory and hypoxic condition, can significantly affect posterior segment parameters, leading to potential visual function impairments in children. Regular monitoring with OCT and OCTA can help detect early microvascular changes, allowing for timely interventions to preserve visual health.

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