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Yayın Axillary mass following BCG vaccination: A rare case diagnosed as lipofibromatosis(Turkiye Klinikleri Yayınevi, 2025) Özdil Yılmaz, İlkiz ÖzgeWe present a case of a 7-month-old male infant who de veloped a progressive, painless left axillary mass 2 months after Bacil lus Calmette-Guérin (BCG) vaccination. Parents reported that the swelling has increased since the 4th month. Initial ultrasound revealed a 16×26×33 mm hyperechoic subcutaneous lesion with a central cystic area and minimal vascularity, suggesting a complicated lipoma. Due to continuous growth, the mass was surgically excised. Histopathological examination confirmed lipofibromatosis, a rare benign fibro-fatty tumor of infancy. Although axillary lymphadenitis is a common BCG com plication, persistent or atypical lesions should prompt further investi gation to rule out neoplasms. This case emphasizes the importance of considering rare soft tissue tumors like lipofibromatosis in the differ ential diagnosis of post-vaccination axillary masses.Yayın Does combined pulmonary fibrosis and emphysema syndrome affect response to antifibrotic therapy and survival? A single-center retrospective cohort study(Mattioli 1885, 2025) Teke, Nazlı Hüma; Ağca, Meltem; Türkar, Ayla; Sevim, Tülin; Tuncay, Eylem; Güngör, Sinem; Yıldırım, Elif; Özbaki, Fatma; Gündoğuş, Baran; Arınç, Sibel; Berk Takır, Huriye; Özmen, İpekObjective: Combined pulmonary fibrosis and emphysema (CPFE) is a clinicoradiological syndrome characterized by upper lobe emphysema and lower lobe fibrosis, most commonly associated with idiopathic pulmonary fibrosis (IPF). This study compared the clinical characteristics, functional parameters, and mortality of patients with CPFE and IPF who received antifibrotic therapy. Methods: Between October 2015 and Au gust 2022, patients with IPF treated with antifibrotics for at least 6 months were retrospectively evaluated and divided into two groups: CPFE (emphysema present) and IPF (emphysema absent). Demographic data, antifi brotic therapy, functional parameters before and after treatment (FEV1%, FVC%, DLco %), clinical outcomes (hospital admissions, mortality) were compared. Results: Of the 204 patients with IPF, 90 (44%) had CPFE. CPFE patients were more often male, had greater smoking history, higher pack-years, and more lung cancer than IPF patients (p < 0.001 for all). Post-treatment FEV1% and FVC% did not significantly differ between the groups, whereas DLco% declined significantly in both (p < 0.001 and p = 0.002). DLco% decreased more in IPF than CPFE, but the difference was not statistically significant [−3 (−11–3) vs. −0.43 (−1.1–0.2), p = 0.36]. The hospital admission rates were similar. Independent risk factors for mortality included CPFE diagnosis (HR: 1.73, 95% CI: 1.06–2.83, p = 0.029), low FVC% (HR: 0.970, 95% CI: 0.96–0.98, p < 0.001), and device use (long-term oxygen therapy [LTOT] or home non-invasive mechanical ventilation [NIMV]) (HR: 2.48, 95% CI: 1.50–4.09, p < 0.001). Mean survival was shorter in patients with emphysema than in those without em physema (5.08 vs. 5.68 years, p = 0.08). Conclusions: Despite a decline in DLco%, changes remained below the futility threshold. Clinical outcomes and mortality were comparable. CPFE diagnosis, low FVC%, and LTOT/ NIMV use independently predicted higher mortality.Yayın More than one century: Intravenous procaine therapy - A systematic review(Salient Visionary Publications LLC, 2025) Oettmeier, Ralf; Nazlıkul, Hüseyin; Pinilla-Bonilla, Laura Bibiana; Ural Nazlıkul, Fatma Gülçin; Reuter, RudolfProcaine, traditionally introduced as a local anaesthetic, has revealed over more than a century a broad spectrum of systemic, pleiotropic pharmacological properties that far exceed its classical use. More than thirty distinct biological mechanisms have now been identified, including anti-inflammatory, vasodilatory, sympatholytic, membrane-stabilising, neuromodulatory, geroprotective, and epigenetically active effects. These actions provide the scientific foundation for its expanding clinical relevance in pain medicine, neuro-regulation, cardiovascular modulation, immune-related and degenerative disorders, and complementary oncology. Within Neural Therapy, Procaine occupies a central and irreplaceable role: its segmental, interference-field–oriented and autonomic-regulatory actions uniquely position it as the primary agent capable of restoring disturbed vegetative patterns, resolving chronic dysfunctions, and re-establishing physiological self-regulation. Beyond its local anaesthetic function, intravenous Procaine—especially in combination with bicarbonate—demonstrates profound regulatory effects on microcirculation, autonomic balance, inflammatory cascades, and mitochondrial and cellular resilience. The so-called “Procaine reset” reflects its capacity to transiently interrupt maladaptive neural patterns, modulate limbic activation, influence neurotransmitter systems, and restore homeostatic regulatory loops. The addition of bicarbonate prolongs Procaine’s plasma availability, enhances its intracellular penetration, and amplifies its eutrophic and anti-inflammatory properties. Although Procaine remains the primary therapeutic molecule in Neural Therapy, Lidocaine has also been utilised in selected clinical contexts. Lidocaine shares certain membrane-stabilising and anti-inflammatory features; however, its pharmacodynamics, autonomic influence, and regulatory depth are comparatively limited. Thus, Lidocaine may complement specific applications but cannot replace the superior vegetative-regulatory potential documented for Procaine. Procaine-Base infusion, when properly adapted to the patient's acid–base balance, represents a cornerstone therapy in regenerative medicine, improving pain thresholds, vascular perfusion, lymphatic drainage, and emotional equilibrium. Its safety profile—documented in hundreds of thousands of applications—is exceptionally favourable, with adverse effects being rare, transient, and mild. Given rising global burdens of chronic inflammatory, neurodegenerative, cardiovascular, metabolic, and oncologic disorders, Procaine emerges as a valuable multi-target regulatory agent capable of reducing symptom burden, complementing multimodal therapeutic strategies, and potentially lowering long-term health-care costs. Future high quality, large-scale studies are warranted to validate its systemic mechanisms, clarify dose–response relationships, and further integrate Procaine-based therapies into modern evidence-based frameworks.Yayın Women’s experiences of breastfeeding during pregnancy: A Turkish descriptive study(Springer Nature Link, 2025) Bayraktar, Sema; İnce, Zeynep; Yıldız, Nevin; Eski, Nuray; Çoban, Emine AsumanBackground Breastfeeding is generally terminated when the mother becomes pregnant again within two years because there is no clear consensus on how to manage breastfeeding during pregnancy. Additionally, health professionals may not have accurate information about this issue. This study aimed to determine women’s attitudes towards breastfeeding during pregnancy and why they stopped breastfeeding when they became pregnant. Methods This study is a descriptive one, involving pregnant mothers with a breastfeeding infant under 2 years old (n=101). The participants were followed up regarding those who had given birth to a new child and chosen the BDP. The researchers surveyed them after birth. The data were collected using a survey form that included a total of 26 questions created by the researchers, which aligned with the existing literature. Data were collected using a questionnaire that included information about maternal, neonatal, and obstetrical data, as well as breastfeeding experience and problems encountered during pregnancy. Data were handled and analyzed using IBM SPSS Statistics v22.0 (SPSS Inc., Chicago, IL, USA). Results The mean age of the mothers was 29.3 years (SD±4.9), gravidity was 3.2 (SD±1.7), and parity was 2.5 (SD±1.1). The mean age of the breastfed children was 12.6 months (SD±5.3) when the mothers became pregnant again. The reasons for stopping breastfeeding were professional advice (35%, n=34), their own decision (30%, n=30), believing that breastfeeding could have adverse effects on the unborn baby, and social pressure (16%). Only 5% (n=5) of mothers continued breastfeeding between 7 and 9 months after pregnancy. Conclusions Our results indicate that when a mother wishes to breastfeed during pregnancy, providing breastfeeding counseling by healthcare professionals with accurate information is essential to sustain lactation and maintain the well-being of the breastfeeding child without harm to the unborn baby.Yayın Examination of sleep disturbances in parkinson’s disease and other movement disorders(Elsevier, 2025) Diaconu, Stefania; Murasan, Iulia; Değirmenci, Yıldız; Falup-Pecurariu, Cristian; Bhidayasiri, Roongroj; Falup-Pecurariu, CristianFrom Bedside to Diagnosis: Practical Competencies in Movement Disorders, Volume 10 in the International Review of Movement Disorders, highlights new advances in the field, with this new volume presenting interesting chapters on important topics such as Movement Disorder Examination: Hypokinetic Disorders, Clinical Approach to Abnormal Facial Movements, Advancing Movement Disorder Education: From Courses to Curriculum, Movement Disorder Examination: Hyperkinetic Disorders.Yayın Complementary and integrative medicine for the treatment of tourette’s syndrome(Wiley, 2025) Pringsheim, Tamara; Deans, Catherine; Anis, Saar; Bhatia, Poonam; Black, Kevin; Değirmenci, Yıldız; Gilbert, Donald; Hartmann, Andreas; Hull, Mariam; Malaty, IreneBackground: There is widespread interest in complementary and integrative medicine (CIM) among people with Tourette's syndrome (TS). Objective: To perform a systematic review of evidence on the use of CIM to reduce tics and improve tic-related quality of life. Methods: We included clinical studies of CIM in children, adolescents and adults with TS and chronic tic disorders, and assessed the change in tic severity and/or tic-related quality of life using validated scales. Risk of bias of randomized controlled trials was assessed using the risk of bias tool of the American Academy of Neurology, which classifies studies into Class I, II, III or IV based on quality criteria. Results: 49 clinical studies and three systematic reviews were included. Most studies were rated Class IV and therefore at high risk of bias. Class I studies demonstrated efficacy of functional MRI neurofeedback, 5-Ling granule, Jingxin Zhidong formula, and Ningdong granule in reducing tic severity. Class II studies suggest efficacy of mindfulness-based intervention for tics, acupuncture combined with atlantoaxial joint bone setting therapy, and art therapy. Systematic reviews summarizing the Chinese literature on acupuncture, acupuncture with herbal medicine and massage therapy suggest greater reduction in tics compared to conventional treatments but there is low confidence in the evidence due to poor methodological quality of included studies. Conclusions: Evidence to support the use of complementary and integrative medicine for TS is limited in methodological quality and widespread applicability. These limitations prohibit evidence-based recommendations for general use among individuals with TS.Yayın A comparative study of deep learning models for automated liver and tumor segmentation in 2d contrast-enhanced MRI images(IEEE, 2025) Tokatlı, Nazlı; Bilmez, Yakuphan; Bayram, Mücahit; Bayır, Beyzanur; Özalkan, Helin; Tekin, Zeynep; Örmeci, Necati; Altun, HalisThis paper presents a comprehensive investigation into deep learning techniques for the automated segmentation of the liver and tumors from 2D abdominal contrast-enhanced Magnetic Resonance Imaging (MRI) slices. Addressing a significant challenge in medical image analysis, our study leverages the public ATLAS dataset [1], using a selection of 60 3D abdominal MRI scans, from which we extracted approximately 3,750 2D slices for model training and evaluation. The core objective was the precise identification and delineation of both the liver organ and any intrahepatic lesions. A comparative analysis was conducted on three U-Net-based architectures: the standard Attention U-Net model incorporating EfficientNet-b3 and CBAM but without Focal Loss, the Attention U-Net model with integrated Focal Loss, and the ResNet34-Based U-Net model. To optimize performance, we explored the efficacy of different loss functions, namely DiceLoss and a hybrid DiceLoss with Focalcoss. Our findings are promising: Among the evaluated models, the ResNet34-Based U-Net demonstrated the highest performance with a Dice score of 91.36% and an IoU score of 89.52%. It was followed by the Attention U-Net with Focal Loss, which achieved 86.41% Dice and 81.61% IoU scores, and the standard Attention U-Net, which obtained 85.93% Dice and 81.19% IoU scores. These results underscore the significant potential of our 2D-based methodology to enhance the precision and efficiency of liver and tumor detection from abdominal scans, offering a valuable tool to support clinicians in early diagnosis and to alleviate their workload.Yayın What is new in the 2025 APASL guidelines for metabolic dysfunction-associated fatty liver disease?(AME Publishing Company, 2026) Pan, Ziyan; Örmeci, Necati; Chen, Jinjun; Ghazinian, Hasmik; Payawal, Diana; Eslam, MohammedAs the global epidemics of obesity and type 2 diabetes mellitus (T2DM) continue to rise, metabolic dysfunction associated fatty liver disease (MAFLD) has become the most common chronic liver disease globally. The Asia-Pacific region is particularly affected, accounting for a significant majority of global liver-related deaths (1). To address this, the Asian Pacific Association for the Study of the Liver (APASL) has released updated clinical practice guidelines in 2025 (2). This article is a commentary focusing on the key changes and new recommendations within those guidelines, which were published in Hepatology International (2). Recognizing the limitations of the exclusionary diagnostic criteria for non-alcoholic fatty liver disease (NAFLD) and emphasizing the key role of metabolic dysfunction in disease pathogenesis, the introduction of the MAFLD definition in 2020 was a milestone in disease research and clinical practice (3-5). This shift reflects a significant evolution in our understanding of the disease, moving away from a diagnosis of exclusion towards one of inclusion based on metabolic dysfunction, recognizing the central role of metabolic factors and introducing the key concept of dual etiology, including alcohol consumption or coexisting liver diseases (6). Over the past 5 years, there have been significant advancements in understanding the disease, culminating in new knowledge, the first approved treatment, and the beginning of a new era of artificial intelligence (AI) with potential promise for hepatology. These changes stimulate the need for an updated document of the APASL guidelines for the diagnosis and management of MAFLD, which was recently released in 2025 (2). This updated guideline provides a comprehensive framework for addressing the growing burden of MAFLD in the Asia-Pacific region. This commentary aims to highlight the key aspects in this landmark document and touch on the main changes from the 2020 version (7).Yayın The african middle east association of gastroenterology (AMAGE) clinical practice guidelines for the diagnosis and management of metabolic dysfunction associated fatty liver disease(Elsevier, 2026) Fouad, Yasser; Elwakil, Reda; Sanai, Faisal M.; Ojo, Olusegun; Al Awadhi, Sameer; Ocama, Ponsiano; Abdelaty, Nadia; Al-Busafi, Said A.; Örmeci, Necati; Eslam, MohammedOver the past few decades, the profile of liver diseases in Africa and the Middle East has undergone significant changes. The incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) has risen to alarming levels. Despite the seriousness of the situation, there is a scarcity of local or regional guidelines established to address it. This document presents the clinical practice guidelines from the African Middle East Association of Gastroenterology (AMAGE) related to the screening, diagnosis, and management of MAFLD. It addresses multiple aspects of managing this condition while taking into account local circumstances and the healthcare system's management requirements. These guidelines are intended for routine clinical use, with a specific focus on particular groups when needed.Yayın Elimination of hepatitis c in Turkey(IntechOpen, 2025) Örmeci, Necati; Musabaev, Erkin IsakovichThis manuscript examines the epidemiological patterns, transmission routes, and genotypic distribution of hepatitis C virus (HCV) in Türkiye, highlighting national progress toward elimination targets set by the World Health Organization (WHO). The main objective is to evaluate the effectiveness of national screening, diagnostic, and treatment strategies, with a focus on the scale-up of direct-acting antiviral (DAA) therapies and their associated cost-effectiveness. Drawing on recent multicenter and population-based studies, the paper outlines the shifting prevalence of HCV geno types, particularly among high-risk populations such as people who inject drugs (PWID), prisoners, and individuals undergoing hemodialysis. The analysis demon strates that genotype 1b remains predominant, though genotype diversity is increas ing due to migration and changing transmission dynamics. Findings reveal that despite improved availability of DAA treatments and health policy initiatives like the 2018–2023 National Viral Hepatitis Program, gaps persist in diagnostic follow-up and referral. The manuscript emphasizes the dual approach of micro- and macro elimination, advocating for integrated care models, increased physician engagement, and enhanced awareness efforts. Projections suggest that achieving WHO goals is feasible in Türkiye if testing and treatment rates significantly improve. Ultimately, this study underscores the necessity of sustained political commitment, intersectoral collaboration, and targeted public-health interventions to reduce HCV-related mor bidity and mortality by 2030.Yayın Clinical characteristics of peripheral joint disease in axial and peripheral spondyloarthritis: Findings from a multicentre cross sectional study(2025) Sarıyıldız, Emine; Duruöz, Mehmet Tuncay; Gezer, Halise Hande; Aktaş, İlknur; Akar, Servet; Hizmetli, Sami; Şahin, Nilay; Akgül, Özgür; Alkan Melikoğlu, Meltem; Sezer, İlhan; Ataman, Şebnem; Ural Nazlıkul, Fatma Gülçin; Çapkın, Erhan; Yılmaz, Figen; Kalyoncu, UmutPeripheral joint disease (PJD) is the most common peripheral manifestation in spondyloarthritis (SpA) patients. This study aimed to determine PJD characteristics and associated factors in patients with axial SpA (AxSpA) and peripheral SpA (pSpA). This cross-sectional and multicenter study involved 13 different rheumatology and physical medicine & reha bilitation clinics, and patients diagnosed with axSpA or pSpA were included in the study. PJD was defined as the ‘ever’ related to SpA according to the physician. Multivariable analyses were conducted to identify factors associated with PJD. A total of 394 patients were enrolled in the study (57.6% male, mean age 40.8 years), of whom 359 (91.1%) were clas sified as AxSpA and 35 (8.9%) as pSpA. Peripheral arthritis was reported in 118 patients (29.9%), comprising 85 (72%) with AxSpA and 33 (28%) with pSpA. Among the whole population with PJD, the main joint involvement pattern was monoarticular (33.9%, n=40) and oligoarticular (49.2%, n=58). The rate of predominantly lower limb and large joint involvement was approximately 60% (n=68) and the major course of PJD was transient (42.4%, n=50) and intermit tent (40.7%, n=48). pSpA patients had a higher rate of persistent (33.3% vs. 14.3%, p=0.021) and progressive arthritis (15.2% vs. 1.2%, p=0.007). The coexistence of PJD with other peripheral involvement and extra-articular manifestations excluding psoriasis was widespread. Dactylitis, enthesitis, and high CRP level were positively associated with PJD; on the contrary, ever alcohol intake, presence of sacroiliitis on MRI, and family history for SpA were negatively associated. PJD was accompanied by both other peripheral involvements and extra-articular manifestations, excluding psoriasis and the course of PJD was more persistent in pSpA patients. This undoubtedly contributes to an increased disease burden.Yayın Evaluation of management strategies for viral upper respiratory tract infections among pediatricians in Türkiye(Taylor & Francis, 2025) Yıldız, İsmail; Gönüllü, Erdem; Uçkun, Utkucan; Kandemir, İbrahim; Soysal, Ahmet; Karaböcüoğlu, MetinBackground: To evaluate how pediatricians manage viral upper respiratory tract infections (URTIs) in children and their tendencies about the viral URTIs approaches. Materials and Methods: This study was conducted among pediatricians who participated in a descriptive cross-sectional survey. The survey included pediatricians who were willing to participate and who completed the survey forms between June 2023 and February 2024. The survey gathered data on the demographic characteristics of the pediatricians, as well as their diagnostic and treatment approaches for viral URTIs. Demographic data included the physicians’ gender, age, academic title, province of duty, institution of practice, and duration of experience in pediatrics. Results: This study involved 203 pediatricians. The diagnosis of viral URTI based on clinical findings had a negative correlation with pediatricians’ work experience (OR: 0.96 per year) and was more common among those working in private settings (OR: 0.38). Use of medications for symptomatic cough treatment was 2.72 times higher among pediatricians in private practice. Herbal supplement use was more common among pediatricians in private practice (p = 0.021) and those with ≥10 years of experience (p = 0.010). Systemic decongestant use was more frequent among pediatricians without an academic title (p = 0.030). Pelargonium sidoides root extract was used more often by pediatricians in private practice (p = 0.003), and they also preferred honey-containing supplements more frequently (p < 0.05). There was a negative correlation between experience in pediatric practice and multivitamins and minerals prescriptions for prevention of viral URTIs (OR: 0.97 for each year). Conclusion: Pediatricians in private settings and with more experience tend not to make a diagnosis of viral URTIs solely based on physical examination. Pediatricians working in private settings focus more on treatments that relieve cough symptoms. A viral URTI diagnostic and treatment algorithm with proven validity will help physicians in clinical diagnosis and treatment.Yayın Effect of slow versus rapid advancement of enteral feeding on intestinal oxygenation in preterm infants(MDPI Publishing, 2025) Özdemir, Hülya; Kersin, Sinem Gülcan; Can Buker, Halime Sema; Çetinkaya, Merih; Kandemir, İbrahim; Memişoğlu, Aslı; Bilgen, Hülya SelvaBackground/Objectives: The optimal rate of enteral feeding advancement in preterm infants remains uncertain despite decades of clinical research. This uncertainty arises from concerns that rapid feeding progression may increase the risk of feeding intolerance and necrotizing enterocolitis (NEC), two major causes of morbidity and mortality in this population. The feeding rate may also influence intestinal oxygenation due to mesen teric hemodynamic changes during feeding. This study aimed to evaluate whether the rate of enteral feeding advancement (slow vs. rapid) affects intestinal oxygenation and its association with feeding intolerance (FI) or necrotizing enterocolitis in very low birth weight preterm infants. Methods: This prospective, randomized, two-center study in cluded infants born at 28–32 weeks of gestation. Group 1 received slow advancement (20 mL/kg/day) and Group 2 rapid advancement (30 mL/kg/day) of enteral feeds. Splanchnic (srSO2) and cerebral (crSO2) oxygenation were monitored daily using the FDA approved INVOS NIRS device during feeding periods (08:00–16:00). Monitoring was per formed during minimal enteral nutrition (Phase 1), advancement phases (Phase 2), and for two days after achieving full enteral feeding (Phase 3). The splanchnic-to-cerebral oxygena tion ratio (SCOR) was also calculated. Percentage changes in srSO2 and SCOR during and after feeding were calculated from baseline (prefeeding) values and analyzed. Results: Sixty infants were enrolled. Mean gestational age and birth weight were 29.76 ± 1.33 weeks and 1375.05 ± 271.19 g, respectively. Group 2 achieved full enteral feeding significantly earlier (p = 0.001), with no other demographic differences between groups. No cases of NEC were observed. Feeding intolerance occurred in 14 infants (23.3%): 8 in Group 1 and 6 in Group 2 (p = 0.192). Both groups exhibited increased srSO2 and SCOR during feeding; however, the between-group differences were not statistically significant (Phase 2 srSO2 and SCOR: p = 0.07, 0.08; Phase 3 srSO2 and SCOR: p = 0.069, 0.071). However, the percentage change from baseline in srSO2 and SCOR during and after feeding was significantly greater in Group 2 during the advancement and full enteral feeding phases (Phase 2 srSO2 and SCOR: p = 0.03, 0.022; Phase 3 srSO2 and SCOR: p = 0.015, 0.048). Infants with feeding intolerance demonstrated significantly lower srSO2 and SCOR values compared to tolerant infants, and this reduction persisted even after reaching full enteral feeding. ROC analysis sug gested gestational age < 30 weeks, birth weight < 1180 g, srSO2 < 52, and SCOR < 0.6 were associated with feeding intolerance. Conclusions: Intermittent bolus feeding increased intestinal oxygenation, with a more pronounced effect in the rapid advancement group. No difference in gastrointestinal adverse outcomes was observed between groups. Lower in testinal oxygenation was associated with feeding intolerance, and the suggested predictive criteria may help guide individualized feeding strategies.Yayın The impact of infant positioning on pain and early neonatal morbidities(Elsevier, 2025) Kersin, Sinem Gülcan; Kandemir, İbrahim; Cıbır, Seval; Özdemir, Hülya; Memişoğlu, Aslı; Bilgen, Hülya SelvaPurpose: To investigate whether appropriate positioning, assessed using the Infant Positioning Assessment Tool (IPAT), is associated with lower pain scores and reduced incidence of early neonatal morbidities in the first week of life in premature infants. Methods: This retrospective observational study was conducted at a single center. The pre-implementation (non IPAT) group was assessed using the NPASS (Neonatal Pain, Agitation, and Sedation Scale) alone, whereas the post-implementation (IPAT) group was evaluated using both the NPASS and the IPAT. Results: The IPAT group consisted of 77 infants, and the non-IPAT group consisted of 40 infants. The mean gestational age and weight of the cases were 29.9 ± 1.2 weeks and 1350 ± 234 g, respectively. Pain scores increased in infants with intraventricular hemorrhage (IVH) (days 3 and 7) and necrotizing enterocolitis (NEC) (days 4 and 5), but decreased with IPAT use on days 5–7. IPAT scores showed a moderate negative correlation with IVH on days 1 and 6, and a strong negative correlation with NEC on day 7. Conclusion: Higher positioning quality is associated with lower pain scores and potentially fewer early morbid ities in preterm infants during the first week of life. Optimal positioning using the IPAT will help establish nursing standards and increase awareness among primary caregivers.Yayın Diffuse alveolar hemorrhage induced by epileptic seizure(Wiley, 2025) Talibov, Tural; İnci, Meltem; Ismayilov, Rashad; Bebek, NersesDiffuse alveolar hemorrhage (DAH) is a rare but life-threatening complication of generalized tonic–clonic seizures. We describe a 28-year-old woman with no prior seizure history who experienced three consecutive generalized tonic–clonic seizures, followed by acute hemoptysis and dyspnea. Imaging confirmed diffuse alveolar hemorrhage, which responded rapidly to corticosteroid therapy. Seizure-induced DAH is an uncommon and underrecognized condition. This case underscores the importance of considering DAH in patients presenting with respiratory symptoms following seizures, even in the absence of underlying systemic disease.Yayın A case of tongue twisting during screening of STN DBS for parkinson’s disease: A unique form of pyramidal tract activation(Turkish Neurosurgical Society, 2025) Değirmenci, Yıldız; Akram, Harith; Dayal, Viswas; Zrinzo, Ludvic; Hariz, Marwan; Limousin, PatriciaSubthalamic nucleus deep brain stimulation (STN-DBS) is a safe and effective therapy for Parkinson´s disease (PD) in selected patients. However, various side effects such as paraesthesia, diplopia, ataxia, worsened akinesia, emotional changes, dysarthria, and muscle contractions can occur due to the current spread to the adjacent structures during the STN-DBS programming sessions. Muscle contractions result from the corticospinal and corticobulbar side effects, which can manifest due to the current spread to the pyramidal tract during DBS programming. Here, we report a case of tongue-twisting movement as a unique corticobulbar side effect of the STN-DBS programming in a patient with PD.Yayın A natural therapeutic approach to fibrocystic breast disease: Antiproliferative effects of phenolic cocktail and metformin on a fibrocystic breast cell line model(Wiley, 2025) Sag, Matej; Pehlevan Karabıyık, Funda; Ceviz Çubukçuoğlu, Ayşe Begüm; Aydoğan, Çağatay; Malikova, Fidan; Yalım, D.; Özkara, Gamze Akın; Öztürk, ÖzmenA natural therapeutic approach to fibrocystic breast disease: antiproliferative effects of phenolic cocktail and metformin on a fibrocystic breast cell line model.Yayın Effects of a polyphenolic chemical mixture on the apoptotis pathway of a triple negative breast cancer cell line(Wiley, 2025) Eronat, Allison Pınar; Ceviz Çubukçuoğlu, Ayşe Begüm; Özkara, Gamze Akın; Yılmaz Aydoğan, Hülya; Öztürk, ÖzmenEffects of a polyphenolic chemical mixture on the apoptotis pathway of a triple negative breast cancer cell line.Yayın Comparative effects of propolis and polyphenolic cocktail (PFK5120) on EGFR signaling in MCF-7 hormone positive breast cancer cell line(Wiley, 2025) Çelik, İrem Nur; Aydoğan, Çağatay; Ceviz Çubukçuoğlu, Ayşe Begüm; Tomaç, Hakan; Öztürk, T.; Yılmaz Aydoğan, Hülya; Öztürk, ÖzmenComparative effects of propolis and polyphenolic cocktail (PFK5120) on EGFR signaling in MCF-7 hormone positive breast cancer cell line.Yayın Cytotoxic effects of polyphenolic cocktail (PFK5120), salicylic acid and indole-3-carbinol combinations on gastric adenocarcinoma cell line(Wiley, 2025) Yalım, Dikmen; Çelik, İrem Nur; Ceviz Çubukçuoğlu, Ayşe Begüm; Aydoğan, Çağatay; Yılmaz Aydoğan, Hülya; Öztürk, T.; Öztürk, ÖzmenCytotoxic effects of polyphenolic cocktail (PFK5120), salicylic acid and indole-3-carbinol combinations on gastric adenocarcinoma cell line.
