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Yayın Diffuse alveolar hemorrhage induced by epileptic seizure(Wiley, 2025) Talibov, Tural; İnci, Meltem; Ismayilov, Rashad; Bebek, NersesDiffuse alveolar hemorrhage (DAH) is a rare but life-threatening complication of generalized tonic–clonic seizures. We describe a 28-year-old woman with no prior seizure history who experienced three consecutive generalized tonic–clonic seizures, followed by acute hemoptysis and dyspnea. Imaging confirmed diffuse alveolar hemorrhage, which responded rapidly to corticosteroid therapy. Seizure-induced DAH is an uncommon and underrecognized condition. This case underscores the importance of considering DAH in patients presenting with respiratory symptoms following seizures, even in the absence of underlying systemic disease.Yayın A case of tongue twisting during screening of STN DBS for parkinson’s disease: A unique form of pyramidal tract activation(Turkish Neurosurgical Society, 2025) Değirmenci, Yıldız; Akram, Harith; Dayal, Viswas; Zrinzo, Ludvic; Hariz, Marwan; Limousin, PatriciaSubthalamic nucleus deep brain stimulation (STN-DBS) is a safe and effective therapy for Parkinson´s disease (PD) in selected patients. However, various side effects such as paraesthesia, diplopia, ataxia, worsened akinesia, emotional changes, dysarthria, and muscle contractions can occur due to the current spread to the adjacent structures during the STN-DBS programming sessions. Muscle contractions result from the corticospinal and corticobulbar side effects, which can manifest due to the current spread to the pyramidal tract during DBS programming. Here, we report a case of tongue-twisting movement as a unique corticobulbar side effect of the STN-DBS programming in a patient with PD.Yayın A natural therapeutic approach to fibrocystic breast disease: Antiproliferative effects of phenolic cocktail and metformin on a fibrocystic breast cell line model(Wiley, 2025) Sag, Matej; Pehlevan Karabıyık, Funda; Ceviz Çubukçuoğlu, Ayşe Begüm; Aydoğan, Çağatay; Malikova, Fidan; Yalım, D.; Özkara, Gamze Akın; Öztürk, ÖzmenA natural therapeutic approach to fibrocystic breast disease: antiproliferative effects of phenolic cocktail and metformin on a fibrocystic breast cell line model.Yayın Effects of a polyphenolic chemical mixture on the apoptotis pathway of a triple negative breast cancer cell line(Wiley, 2025) Eronat, Allison Pınar; Ceviz Çubukçuoğlu, Ayşe Begüm; Özkara, Gamze Akın; Yılmaz Aydoğan, Hülya; Öztürk, ÖzmenEffects of a polyphenolic chemical mixture on the apoptotis pathway of a triple negative breast cancer cell line.Yayın Comparative effects of propolis and polyphenolic cocktail (PFK5120) on EGFR signaling in MCF-7 hormone positive breast cancer cell line(Wiley, 2025) Çelik, İrem Nur; Aydoğan, Çağatay; Ceviz Çubukçuoğlu, Ayşe Begüm; Tomaç, Hakan; Öztürk, T.; Yılmaz Aydoğan, Hülya; Öztürk, ÖzmenComparative effects of propolis and polyphenolic cocktail (PFK5120) on EGFR signaling in MCF-7 hormone positive breast cancer cell line.Yayın Cytotoxic effects of polyphenolic cocktail (PFK5120), salicylic acid and indole-3-carbinol combinations on gastric adenocarcinoma cell line(Wiley, 2025) Yalım, Dikmen; Çelik, İrem Nur; Ceviz Çubukçuoğlu, Ayşe Begüm; Aydoğan, Çağatay; Yılmaz Aydoğan, Hülya; Öztürk, T.; Öztürk, ÖzmenCytotoxic effects of polyphenolic cocktail (PFK5120), salicylic acid and indole-3-carbinol combinations on gastric adenocarcinoma cell line.Yayın Polyphenolic cocktail (PFK5120) treatment of breast cancer cell lines: superior anti-carcinogenic and anti-metastatic effects to doxorubicin(Wiley, 2025) Özkara, Gamze Akın; Ceviz Çubukçuoğlu, Ayşe Begüm; Çelik, İrem Nur; Korkmaz, Nur Damla; Öztürk, Özmen; Yılmaz Aydoğan, HülyaPolyphenolic cocktail (PFK5120) treatment of breast cancer cell lines: superior anti-carcinogenic and anti-metastatic effects to doxorubicinYayın Molecular perspective on gemcitabine resistance in PANC-1 and PANC-1GemR pancreatic cancer cells: The potential role of polyphenolic cocktail (PFK5120) in overcoming chemoresistance(Wiley, 2025) Ceviz Çubukçuoğlu, Ayşe Begüm; Aydoğan, Çağatay; İbrahimova, Gülnar; Yılmaz Aydoğan, Hülya; Öztürk, ÖzmenMolecular perspective on gemcitabine resistance in PANC-1 and PANC-1GemR pancreatic cancer cells: The potential role of polyphenolic cocktail (PFK5120) in overcoming chemoresistance.Yayın Safety monitoring of colistin therapy in critically ıll neonates with late-onset sepsis: A retrospective observational study(British Pharmacological Society, 2025) Acargök, Baran Cengiz; Yaman, Akan; Rzayev, Turkay; Jalalzada, Nazlı; Kandemir, İbrahim; Memişoğlu, Aslı; Bilgen, Hülya SelvaThis study aimed to evaluate the safety of colistin therapy by monitoring renal function and electrolyte levels in critically ill neonates with late-onset sepsis (LOS) hospitalized in the neonatal intensive care unit (NICU) between 2015 and 2021. This ret rospective case–control study included 58 critically ill neonates treated with colistin for late-onset sepsis and 22 control neonates with late-onset sepsis who did not receive colistin. Data were analyzed to compare patient outcomes, microbiological profiles, and side effects of treatment. Statistical analyses were performed using repeated-measures ANOVA and Bayesian calculations to evaluate serum creatinine levels and biochemical parameters over time. Serum creatinine levels showed similar alterations within the first 7days of colistin treatment with moderate evidence. However, serum magnesium and sodium levels were lower on the 7th day in the colistin-treated group compared with the control group. Colistin therapy in critically ill neonates with late-onset sepsis appears to be a viable treatment option with an acceptable short-term safety profile. These findings emphasize the importance of routine monitoring of renal function and electrolyte levels during colistin use in neonatal intensive care to minimize potential complications.Yayın Reflectance confocal microscopy for differentiating clear cell acanthoma from squamous cell carcinoma in situ(Galenos Publishing House, 2025) Oraloğlu, Göktürk; Duman, Nilay; Yaman, Banu; Karaarslan, IşılBackground and Design: There are few reports on the in vivo reflectance confocal microscopy (RCM) features of clear cell acanthoma (CCA). This study aimed to evaluate the diagnostic ability of RCM in CCAs that are difficult to diagnose clinically and to compare the RCM findings with those observed in squamous cell carcinoma in situ (SCCIS) lesions, which exhibit similar clinical morphology. Materials and Methods:We searched our database and identified three cases of CCA with atypical features and three cases of SCCIS with common morphological features. We described the clinical, dermoscopic, RCM, and histopathological characteristics of these cases. Results: Both lesion groups showed prominent epidermal hyperplasia on RCM; however, atypia in epidermal cells in CCAs was not as pronounced as that in SCCISs. The general architecture was preserved in the CCAs. In SCCISs, epidermal basal cells were increased in size, and prominent pleomorphism and atypia were observed in the full-thickness epidermis, whereas basal cells in CCAs were normal in pattern and appearance. Conclusion: We suggest that differentiating CCA from SCCIS on RCM is possible, even in atypical cases, by careful evaluation of the general architecture of the tumor and determination of the degree of epidermal disarray, nuclear features of the epidermal cells, presence of uniformity or pleomorphism of the epidermal cells, and features of the basal cells. A comparison of normal skin and tumor areas may also help in better evaluation.Yayın Investigation of the association between nitric oxide synthase gene variants and NAFLD in adolescents with obesity(De Gruyter, 2025) Hasanoğlu Sayın, Sevde; Kandemir, İbrahim; Oyacı, Yasemin; Khudiyeva, Shahri; Şahin, Memduh; Yetim Şahin, Aylin; Pehlivan, SacideObjectives: The present study aimed to investigate whether nitric oxide synthase (NOS) enzyme gene variants (iNOS rs1060826, eNOS rs1799983, eNOS 27-bp VNTR) play a role in the etiopathogenesis of nonalcoholic fatty liver (NAFLD) in adolescents. Methods: This cross-sectional study was conducted with obese adolescents [body mass index (BMI) standard devia tion score (SDS) ≥2] aged 10–19 years (104 individuals) and age- and sex-matched healthy individuals (64 individuals) whose presence of NAFLD was determined by ultrasound. The iNOS rs1060826 and eNOS rs1799983 variants were performed by Polymerase Chain Reaction-Restriction Frag ment Length Polymorphism (PCR-RFLP) method, and the eNOS 27-bp VNTR variant was analyzed using the PCR method. The genotypes detected were compared between the patient group and the healthy controls and with the clinical parameters of the patients. Results: iNOS rs1060826 and eNOS rs1799983 were inde pendent of obesity, whereas eNOS 27-bp VNTR was inde pendent of NAFLD. However, in the obese group, especially in those with NAFLD (+), the iNOS rs1060826 GG genotype was found to be associated with lower diastolic blood pres sure (DBP) (p=0.011). Compared with the clinical parameters, insulin resistance (HOMA-IR) was higher in those carrying the eNOS rs1799983 gene variant-TT genotype in the NAFLD (+) group (p=0.051). Conclusions: While the three functional gene variants of the NOS enzyme did not show a significant difference in terms of genotype between patients and healthy controls, it was determined that both the iNOS rs1060826 gene variant GG allele was associated with low DBP and HOMA-IR may be higher in those carrying the eNOS rs1799983 gene variant TT genotype in NAFLD (+) patients. The iNOS rs1060826 poly morphism is a potentially important genetic variant that may influence DBP regulation through its effects on nitric oxide production.Yayın Dermoscopy-guided surveillance in xeroderma pigmentosum: A retrospective analysis(Galenos Publishing House, 2025) Oraloğlu, Göktürk; Duman, Nilay; Yaman, Banu; Akalın, Taner; Karaarslan, IşılAim: Xeroderma pigmentosum (XP) is a life-threatening disease characterized by high rates of skin cancers. Therefore, it is important to establish key guidelines for the follow-up of these patients to detect skin cancers, particularly melanoma, at an early stage. Materials and Methods: This is a retrospective study that includes the analysis of the follow-up findings and medical records of XP patients who were followed up with whole-body skin examination, dermoscopic examination, and whole-body photographing between 2003 and 2021 in the Dermato Oncology unit of Ege University Department of Dermatology. Results: Of the 19 patients, 10 were male and 9 were female. The youngest patient was 5 years old, while the oldest patient was 64 years old. A total of 234 lesions were excised from these patients. Seventeen melanomas were excised, including 11 in situ, with a Breslow thickness of less than 1 mm. The highest Breslow scores belong to patients who missed their appointments or did not receive follow-up care previously. Conclusion: It was observed that regular full-body skin examinations, whole-body photography, and dermoscopic monitoring performed at 3-month intervals in XP patients are helpful in detecting skin malignancies at an early stage and preventing unnecessary excisions.Yayın Red cell distribution width-to-platelet ratio and other hematological markers as early predictors of bronchopulmonary dysplasia in preterm infants(MDPI Publishing, 2025) Arcagök, Baran Cengiz; Kandemir, İbrahimBackground/Objectives: Bronchopulmonary dysplasia (BPD) frequently affects preterm infants and is associated with lasting morbidity. Early prediction remains challenging. The present study investigated whether hematological inflammatory markers—platelet-to-lymphocyte ratio (PLR), red cell distribution width (RDW), and red cell distribution width-to-platelet ratio (RPR)—can predict the development of BPD in preterm neonates. Methods: We performed a retrospective cohort study involving 100 infants born at less than 32 weeks’ gestation. Complete blood count (CBC) parameters were collected at birth, 72 h, 1 week, and 2 weeks of life. Associations between PLR, RDW, RPR, and BPD development were analyzed. Multivariate regression and receiver operating characteristic (ROC) curve analyses were carried out to evaluate the predictive performance of the markers. Results: Forty-nine percent of infants developed BPD. Those with BPD had significantly higher RDW, PLR, and RPR values, and lower lymphocyte and platelet counts at various time points. Gestational age, respiratory distress syndrome, and hematological indices independently predicted BPD. ROC analysis showed that RDW ≥ 67.2 and PLR ≥ 98.13 at 72 h, and RPR ≥ 0.3 at 7 and 14 days had good predictive performance. A combined scoring system, including clinical and hematological markers, achieved high sensitivity and specificity. Conclusions: Hematological inflammatory markers, especially RPR, PLR, and RDW, derived from routine CBC tests may serve as accessible, cost-effective tools for early BPD risk stratification in preterm infants. Additional studies are needed to confirm these results and better define their relevance in clinical practice.Yayın Diagnostic value of leukocyte count, c-reactive protein, and procalcitonin in pediatric liver transplant patients during the first week postoperative: A longitudinal study from a tertiary center and a new diagnostic method for predicting systemic infection(MDPI Publishing, 2025) Önal, Zerrin; Türkmen, Elif; Demirkol, Demet; Leblebici, Uğur Can; Kandemir, İbrahim; Yılmaz, Tuğçe Göksu; Torun, Selda Hançerli; Ekiz, Feza; Özden, Ilgın; Durmaz, ÖzlemBackground/Objectives: Infection is a major complication during the early postoperative period following pediatric liver transplantation (LT). Prompt diagnosis and treatment are essential to prevent death. We aimed to assess the diagnostic value of procalcitonin (PCT), white blood cell count (WBC), and C-reactive protein (CRP) levels for detecting bacterial infection and SIRS within the first week after LT. Methods: Demographic data, vital signs, laboratory results (PCT, CRP, WBC), and culture findings on the 1st, 4th, and 7th days between January 2010 and 2024 were collected retrospectively. Results: The study included 88 patients. Seventy-two percent had cirrhotic liver disease. SIRS was present in 17% (n = 15), and bacterial growth was detected in 20% (n = 18). Bacterial growth was found in 80% of patients with SIRS (n = 12/15) and in 8% of SIRS-negative patients (n = 6/73). PCT levels were significantly elevated on days 1, 4, and 7, and CRP lev els on days 4 and 7 in patients with SIRS. PCT elevation was significant on days 1, 4, and 7, while WBC increase was noted on day 7 in patients with bacterial growth. Body temperature ≥ 37.1 ◦C and PCT ≥ 5.1 ng/dL on the first day together showed a sensitivity of 72.2% and specificity of 84.3% for bacterial growth. Similarly, body temperature ≥ 37.1 ◦C and PCT ≥ 9.2 ng/dL on the first day yielded 73% sensitivity and 95% specificity for diagnosing SIRS. Cirrhotic patients exhibited limited or no WBC response to bacterial growth. Conclusions: PCT, CRP, and WBC alone are insufficient for diagnosing infection. Combined assessment of body temperature changes and PCT elevation may serve as more accurate indicators. Nonetheless, close monitoring of culture results and clinical signs, with serial physical exams, can aid timely infection management or prevent unnecessary antibiotic adjustments.Yayın Management of acute variceal bleeding: Updated APASL guidelines(Springer Nature Link, 2025) Lesmana, Cosmas Rinaldi Adithya; Shukla, Akash; Kumar, Ashish; Shalimar; Qi, Xiaolong; Gani, Rino Alvani; Dökmeci, Abdul Kadir; Örmeci, Necati; Sarin, Shiv KumarAcute variceal bleeding (AVB) is a common life-threatening complication of portal hypertension (PHT), having a six-week mortality of 10%-20%. Major advances in the hemodynamic management, risk stratification, pharmacotherapy, endoscopy techniques, hemostatic devices and radiological interventions have led to improved management and outcome of AVB patients in the recent past. Therefore, the APASL Portal Hypertension Working Party, chose a panel of experts, primarily from the Asia–Pacific region, to identify important developments and controversial areas in the field of AVB. They discussed through a pre-defined and structured process, advances in the field and proposed updates to the previous APASL AVB guidelines. These included emphasis on safe transportation, defining time frames for AVB episodes and re-bleeding, reporting of clinical outcomes, optimizing early intervention strategies, pharmacotherapy, medical management, endoscopic therapies, and salvage modalities, including TIPS and self-expanding metal stents. The current updates also cover variceal bleeding in special populations and situations, the skill sets required for managing AVB patients, and the research priorities in the field. The updated guidelines are based on the latest evidence and incorporate emerging trends to provide a contemporary template for management of AVB in both patients with cirrhosis and non-cirrhotic portal hypertension.Yayın MAFLD: A comprehensive review of the link between metabolic dysfunction and cardiovascular risk(Taylor & Francis, 2025) M. Mostafa, Alaa; Pan, Ziyan; Yu, Ming-Lung; Örmeci, Necati; Fouad, Yasser; Eslam, MohammedMetabolic dysfunction-associated fatty liver disease (MAFLD) affects over 30% of the global population. It is a multisystem condition with a strong association with cardiovascular disease (CVD), the leading cause of mortality worldwide. Key shared mechanisms, including insulin resistance, systemic inflammation, oxidative stress, and genetic predisposition, couple MAFLD with increased risks of coronary artery disease, ischemic heart disease, and heart failure. Early detection via non-invasive imaging and biomarkers is crucial for effective risk stratification. Management strategies emphasize lifestyle modifications and the development of targeted pharmacotherapies addressing metabolic and inflammatory pathways. Understanding the interconnected pathogenic mechanisms facilitates personalized interventions to reduce morbidity and improve long-term outcomes. A multidisciplinary approach remains essential to prevent and manage the cardiovascular implications of MAFLD.Yayın Evaluation of posterior segment changes in pediatric asthma patients with and without inhaled corticosteroid therapy(Springer Nature, 2025) Kıvrak, Ulviye; Çiçek, Fatih; Köle, Mehmet Tolga; Kaya Adaş, Büşra; Kandemir, İbrahimThis study aimed to evaluate and compare changes in the posterior segment of pediatric asthma patients, potentially associated with asthma or inhaled corticosteroids. A retrospective analysis was conducted on children aged 7–17 diagnosed with atopic asthma. The participants were categorized into groups: Group 1 (no inhaled corticosteroids) and Group 2 (inhaled corticosteroid treatment). A control group of healthy children was also included. Demographic data, clinical findings, and laboratory results (e.g., eosinophil count, IgE, CRP levels) were collected. Optical coherence tomography (OCT) and OCT angiography (OCTA) were used to measure posterior segment parameters. Asthma patients demonstrated a statistically significant reduction in subfoveal choroidal thickness, the superficial capillary plexus in the superior and nasal quadrants, the choriocapillaris in the foveal quadrant, and the peripapillary vascular density in the inferior and superior quadrants compared to controls. Inflammation markers such as eosinophil count and CRP showed significant correlations with changes in vascular density. Asthma, as a chronic inflammatory and hypoxic condition, can significantly affect posterior segment parameters, leading to potential visual function impairments in children. Regular monitoring with OCT and OCTA can help detect early microvascular changes, allowing for timely interventions to preserve visual health.Yayın In vivo reflectance confocal microscopy for detecting cutaneous metastasis in breast cancer(Mattioli 1885, 2025) Duman, Nilay; Yaman, Banu; Oraloğlu, Göktürk; Kararaslan, IşılA 45-year-old female with a history of invasive ductal breast carcinoma (IDBC) presented with an asymptomatic erythematous nodule on the right mastectomy scar. Dermos copy revealed erythematous peripheral border, polymor phous and atypical vessels, focal scaling, and multiple white structureless areas appearing as white clods and strands. Reflectance confocal microscopy (RCM) revealed a normal epidermis with a preserved honeycombed pattern, with der mal tumoral clusters of varying sizes consisting of highly polymorphous hyporeflective cells with different sizes and shapes.Yayın Presence of myositis specific autoantibodies including anti synthetase antibodies predict favorable outcomes to rituximab in patients with idiopathic inflammatory myositis: Retrospective observational study(Elsevier, 2025) Oğuz, Eyüp; Koca, Nevzat; Bektaş, MuratBackground: Idiopathic inflammatory myositis (IIM) is a group of disorders that mainly affect skeletal muscle, joints, skin, and lungs. Objectives: This study aimed to evaluate the autoantibody profile including myositis-associated autoantibodies (MAAs) and myositis-specific autoantibodies (MSAs) and their influence on outcomes, response rates, and associated factors to Rituximab (RTX) treatment in patients with IIM who followed up in a single tertiary center. Methods: Data from the patients with IIM who follow-up between 2019 and 2023 years and met the Bohan and Peter and/or the ACR/EULAR 2017 and/or the ENMC criteria were retrospectively reviewed. RTX was initiated in patients who had an inadequate response to at least one immonomudulatory/immunosuppressive treatment (refractory group) or as a first-line treatment in patients who had critical/severe disease manifestations such as respiratory failure due to severe intertitial lung disease (ILD), respiratory muscle involvement, and dysphagia. RTX was administered at a dose of 1 g every 6 months on days 0-15, and the dose was repeated at month 6 in patients who responded to treatment. Remission was defined as the patients who met all of the following criteria during at least 6 months: i) absence of a sign of muscle inflammation by manual muscle test (normalization of muscle strength in patients without damage) alongside muscle enzymes (normalization in CK and LDH levels), ii) improvement or no progression in respiratory symptoms alongside pulmonary function tests (less than 10% decline in FVC and/or DLCO) in patients who had ILD at baseline, iii) disappearance of active skin lesions among dermatomyositis (DM) patients iv) resolution of other features attributed to several manifestations such as arthritis, heart involvement and gastrointestinal symptoms if present.Yayın Manuel tıp manuel terapi fonksiyonel diyagnoz ve manipülasyon teknikleri(Ankara Nobel Tıp Kitabevleri, 2025) Nazlıkul, Hüseyin; Ural Nazlıkul, Fatma GülçinBu kitabın yazılması sürecinde, manuel tıbbın mesleki gelişimimdeki yerini ve öne mini bir kez daha derinlemesine anlama fırsatı buldum. Fizik tedavi ve rehabilitasyon alanında uzmanlaşmış bir akademisyen olarak, kas-iskelet sistemi hastalıklarında başarı lı olmanın, bu alanın inceliklerini anlamak ve uygulamakla mümkün olduğunu gördüm. Bu farkındalığımı, manuel tıpla ve nöralterapi ile tanışmama ve bu disiplinleri kazandı ğım bilgi birikimine borçluyum. Klasik tıpta segmental fonksiyon bozukluklarını ve bunların ilgili organlarla ilişkisini çoğu zaman göz ardı ediyorduk. Oysa manuel tıpla doğru tanı koymanın ve hastaya do kunarak muayene yapmanın ne kadar etkili olduğunu fark ettim. Artık basit bir halluks valgus gibi durumlarda dahi radyolojik görüntülerden çok, hastaya dokunmanın önemi ni daha iyi anlıyorum. Basit bir ortopedik problemde dahi hastaya dokunarak muayene yapmak, pek çok sorunun kaynağını hemen ortaya koyabiliyor. Manuel tıp, eklemler, kaslar ve bağ dokular üzerinde elle yapılan tanı ve tedavi yöntem lerini içerir. Bu yaklaşım, hareket sistemindeki fonksiyonel bozuklukların giderilmesine ve ağrının azaltılmasına odaklanır. Nöralterapi ise vücudun sinir sistemini düzenleyerek, ağrı ve fonksiyon bozukluklarını tedavi etmeyi amaçlar. Bu iki yöntemin kombinasyonu, birçok durumda hastaların daha hızlı iyileşmesini sağlar ve tedavi sürecini daha etkili hale getirir. Almanya’da katıldığım ileri düzey manuel tıp ve nöralterapi eğitimleri, mesleğimdeki bakış açımı zenginleştirirken, manuel tıbbın sadece bir tedavi yöntemi değil, aynı zaman da bir hekimlik sanatı olduğunu anlamama vesile oldu. Sevgili hocam Wolfgang von Hey mann, 2019 yılında aramızdan ayrıldı. Onunla birlikte Hüseyin Nazlıkul ile başladığımız bu değerli projeyi tamamlayarak hekimlerle buluşturmak, benim için bir onur kaynağıdır.
