Synthesis, cytotoxic activity evaluation and molecular docking studies of some benzimidazole derivatives

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dc.authorid0000-0002-0841-1299en_US
dc.authorscopusid7004056031en_US
dc.authorwosidEUU-1475-2022en_US
dc.contributor.authorKaya, Aybüke Züleyha
dc.contributor.authorOsmaniye, Derya
dc.contributor.authorEvren, Asaf Evrim
dc.contributor.authorYurttaş, Leyla
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned2024-04-04T08:28:17Z
dc.date.available2024-04-04T08:28:17Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.description.abstractIn this study, the synthesis of 2-(2-acetyl-1H-benzimidazol-1-yl)-1-arylethanone (3a-3d) and 1-methyl-3-phenylbenzo[4,5]imidazo[1,2-a]pyrazine derivatives (4a-4d) and to investigate their cytotoxic activity were aimed. APCI, IR, 1HNMR, and 13CNMR spectra were utilized to determine the structure of the synthesized compounds. The cytotoxic activity of selected compounds were detected in A549 (human lung carcinoma) and NIH3T3 (mouse embryonic fibroblasts) cell lines. Compounds 4c and 4d were found to be selectively cytotoxic against A549 and NIH3T3 cell lines. Molecular docking studies were performed using the data retrieved from the Protein Data Bank server (PDBID: 4QTX).en_US
dc.identifier.citationKaya, A. Z., Osmaniye, D., Evren, A. E., Yurttaş, L., & Demirayak, Ş. (2024). Synthesis, cytotoxic activity evaluation and molecular docking studies of some benzimidazole derivatives. Cumhuriyet Science Journal, 45(1), pp. 80-87. https://doi.org/10.17776/csj.1392037en_US
dc.identifier.doi10.17776/csj.1392037en_US
dc.identifier.endpage87en_US
dc.identifier.issn2587-2680
dc.identifier.issn2587-246X
dc.identifier.issue1en_US
dc.identifier.startpage80en_US
dc.identifier.trdizinid1230144
dc.identifier.urihttps://doi.org/10.17776/csj.1392037
dc.identifier.urihttps://hdl.handle.net/20.500.13055/686
dc.identifier.volume45en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorDemirayak, Şeref
dc.language.isoenen_US
dc.publisherSivas Cumhuriyet Universityen_US
dc.relation.ispartofCumhuriyet Science Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBenzimidazoleen_US
dc.subjectPyrazinobenzimidazoleen_US
dc.subjectAnticanceren_US
dc.subjectMolecular Dockingen_US
dc.titleSynthesis, cytotoxic activity evaluation and molecular docking studies of some benzimidazole derivativesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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