Microbiota signatures and genetic risk in pediatric celiac disease

Basit Öğe Kaydı
dc.authorid0000-0002-6993-0383
dc.authorid0000-0002-4549-3887
dc.authorid0000-0003-1072-3846
dc.contributor.authorAkçin, Rüveyda
dc.contributor.authorSarıbaş, Suat
dc.contributor.authorKocazeybek, Bekir
dc.date.accessioned2026-09-12T08:50:11Z
dc.date.available2026-09-12T08:50:11Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractCeliac disease (CD) is a chronic, immune-mediated enteropathy triggered by dietary gluten in genetically susceptible individuals, most commonly those carrying human leukocyte antigen-DQ2 or human leukocyte antigen-DQ8 hap lotypes. However, because these haplotypes are prevalent in the general population while only a minority of carriers develop disease, additional factors are likely to contribute to disease onset and progression. In recent years, the gut microbiota has emerged as a potential mediator between host genetic suscept ibility and environmental triggers, particularly in pediatric CD. Current evidence suggests that children with CD exhibit reduced microbial diversity, depletion of beneficial commensals, enrichment of proinflammatory taxa, and broader alte rations extending to fungal and viral communities. However, these findings re main heterogeneous, largely due to variability in study design, sampling sites, diet, age, and analytical methods. This review examines the interplay between host genetic risk and the intestinal microbiota in pediatric CD, with emphasis on bacterial, fungal, and viral components. Moreover, it highlights the importance of longitudinal, functionally oriented, and multi-omics approaches, particularly in genetically at-risk yet clinically unaffected children, to better clarify causality and identify early microbial markers of disease susceptibility.
dc.identifier.citationAkçin, R., Sarıbaş, S., & Kocazeybek, B. (2026). Microbiota signatures and genetic risk in pediatric celiac disease. World Journal of Gastroenterology, 32(38), pp. 1-12. https://dx.doi.org/10.3748/wjg.119677
dc.identifier.doi10.3748/wjg.119677
dc.identifier.endpage12
dc.identifier.issn1007-9327
dc.identifier.issue38
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://dx.doi.org/10.3748/wjg.119677
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1635
dc.identifier.volume32
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorAkçin, Rüveyda
dc.institutionauthorid0000-0002-6993-0383
dc.language.isoen
dc.publisherBaishideng Publishing Group Inc.
dc.relation.ispartofWorld Journal of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGut Microbiota
dc.subjectHuman Leukocyte Antigen
dc.subjectMycobiome
dc.subjectPediatric Celiac Disease
dc.subjectVirome
dc.titleMicrobiota signatures and genetic risk in pediatric celiac disease
dc.typeReview Article
dspace.entity.typePublication

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