Poly(bromophenol blue)/CoSn(OH)6 cubic particles modified pencil graphite electrode for electrochemical determination of diphenhydramine

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dc.authorid0000-0002-6401-3295
dc.authorid0000-0001-9746-3682
dc.authorid0000-0003-0745-6863
dc.authorid0000-0002-2980-6871
dc.contributor.authorKarakaya, Serkan
dc.contributor.authorBakırdere, Sezgin
dc.contributor.authorŞaylan, Meltem
dc.contributor.authorDilgin, Yusuf
dc.date.accessioned2026-07-25T07:57:14Z
dc.date.available2026-07-25T07:57:14Z
dc.date.issued2026
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalı
dc.description.abstractIn this study, a poly(bromophenol blue) (poly(BPB))-coated CoSn(OH)6 cubic particles -modified pencil graphite electrode (poly(BPB)@CoSn(OH)6/PGE) was developed, and its electrochemical activity towards diphenhydramine (DPHN) oxidation was systematically investigated. Cyclic voltammetric studies revealed that the oxidation of DPHN at the modified electrode is governed by a diffusion-controlled process, indicating strong interaction between DPHN molecules and the poly(BPB) film. The incorporation of the CoSn(OH)6 cubic structure enhances electron transfer kinetics by increasing the density of electroactive sites and facilitating charge transport across the electrode interface. This cooperative interaction between the conductive polymer and metal hydroxide structure results in a significant amplification of the oxidation response. Under optimized conditions, the proposed electrode exhibited a linear response in the concentration range of 1.0-500.0 µM with a detection limit (LOD) of 0.30 µM. Although the analytical performance is comparable to previously reported systems, the present work provides deeper insight into the role of polymer-metal hydroxide interfaces in governing electrochemical sensing behavior. The sensor also demonstrated acceptable selectivity and applicability in pharmaceutical, biological, and environmental samples. These findings highlight the importance of interfacial design in improving electrochemical performance and offer a useful framework for developing advanced hybrid sensing platforms.
dc.identifier.citationKarakaya, S., Bakırdere, S., Şaylan, M., & Dilgin, Y. (2026). Poly(bromophenol blue)/CoSn(OH)6 cubic particles modified pencil graphite electrode for electrochemical determination of diphenhydramine. Scientific Reports, https://doi.org/10.1038/s41598-026-60620-9
dc.identifier.doi10.1038/s41598-026-60620-9
dc.identifier.issn2045-2322
dc.identifier.pmidPMID: 42387183
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1038/s41598-026-60620-9
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1561
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorŞaylan, Meltem
dc.institutionauthorid0000-0003-0745-6863
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiphenhydramine
dc.subjectBromophenol Blue
dc.subjectCoSn(OH)6 Cubic Particles
dc.subjectPencil Graphite Electrode
dc.subjectCyclic Voltammetry
dc.subjectElectrochemical Sensor
dc.titlePoly(bromophenol blue)/CoSn(OH)6 cubic particles modified pencil graphite electrode for electrochemical determination of diphenhydramine
dc.typeArticle
dspace.entity.typePublication

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