Nanocrystal based approach in colon targeting

Basit Öğe Kaydı
dc.authorid0000-0001-6915-0283
dc.authorid0000-0002-8199-3010
dc.authorid0000-0002-9110-3704
dc.contributor.authorPirinçci Tok, Yağmur
dc.contributor.authorGüngör, Sevgi
dc.contributor.authorÖzsoy, Yıldız
dc.date.accessioned2025-06-23T11:08:39Z
dc.date.available2025-06-23T11:08:39Z
dc.date.issued2025
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractNanocrystals have unique characteristics among of the drug delivery systems in nanosized through high drug loading, favorable effects on pharmacokinetics, reduced toxicity, and easy of scaling-up. Nanocrystals are basically active pharmaceutical ingredient particles in the nanometer range, which is described generally as nanosuspension since they are produced by surrounding a stabilizer and suspending in a dispersion media. They can be administered via oral, buccal, nasal, pulmonary, parenteral, and ocular routes with different formulation technologies or brain delivery of nanocrystals. In recent years, there has been increased interest in colon-targeting nanocrystals where chitosan-derived stabilizers, pH-sensitive and time-released approaches, coating, and encapsulation strategies are being preferred. In this chapter, the features of drug nanocrystals, the principles of their manufacturing methods as well as stabilization mechanism of nanocrystals, and stabilizer agents used for their production and stabilization of the nanosuspension are handled out and the strategies focus on colon-targeting of nanocrystals drug delivery will be summarized. © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
dc.identifier.citationPirinçci Tok, Y., Güngör, S., & Özsoy, Y. (2025). Nanocrystal based approach in colon targeting. Nanocarriers Based Colon Targeting, pp. 569-600. https://doi.org/10.1016/C2023-0-51105-X
dc.identifier.doi10.1016/C2023-0-51105-X
dc.identifier.endpage600
dc.identifier.isbn9780443248061
dc.identifier.startpage569
dc.identifier.urihttps://doi.org/10.1016/C2023-0-51105-X
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1006
dc.indekslendigikaynakScopus
dc.institutionauthorPirinçci Tok, Yağmur
dc.institutionauthorid0000-0001-6915-0283
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofNanocarriers Based Colon Targeting
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBioavailability
dc.subjectColon Targeting
dc.subjectDrug Nanocrystals
dc.subjectEnhancement Solubility
dc.subjectNanocrystals
dc.subjectNanosuspension
dc.subjectPhysical Stability
dc.subjectPoor
dc.subjectSolubility
dc.subjectStabilizers
dc.subjectSurface Modification
dc.titleNanocrystal based approach in colon targeting
dc.typeBook Chapter
dspace.entity.typePublication

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Farmasötik Teknoloji Ana Bilim Dalı Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu