Immunolocalization of FOXP3, JAK1 and STAT5in preeclamptic, intrauterine growth restricted and gestational diabetic human placentas

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dc.authorid0000-0001-9513-5706en_US
dc.authorscopusid57195559466en_US
dc.authorwosidAAP-3523-2020en_US
dc.contributor.authorEmirdar, Volkan
dc.contributor.authorEkizceli, Gülçin
dc.contributor.authorDilber, Yağmur
dc.contributor.authorİnan, Sevinç
dc.contributor.authorSancı, Muzaffer
dc.date.accessioned2021-12-27T06:56:56Z
dc.date.available2021-12-27T06:56:56Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractObjective: The aim of the study to show the relation of T cells in placental villous fragments with FOXP3,JAK1 and STAT5 receptors in different conditions such as GDM, PE and IUGR placental tissues. Materials and Methods: Specimens of 10 diabetic placentas, 10 preeclamptic, 10 intrauterine growth restricted placentas and 10 control placentas were collected by systematic uniform random sampling. Immunohistochemical detections of FOXP3, JAK1 and STAT5 were performed in histological Sections for each group’s placental tissue. The score value was derived for each specimen by calculating the sum of the percentage of syncytiotrophoblast and syncytial nodes in placenta and intervillus area. They were categorized by intensity of staining, multiplied by its respective score. Results: FOXP3, JAK1 and STAT5 immunoreactivity comparisons are shown in four groups of placentas. FOXP3 immunoreactions significantly increase in GDM group. JAK1 and STAT5 immunoreactions significantly decrease in PE group. STAT5 immunoreactivity was detected crucially increase in GDM group. Conclusion: The results showed that in different conditions such as PE, GDM and IUGR, T cells in placental villous fragments have relation with FOXP3,JAK1 and STAT5 receptors and that FOXP3 can inactivate the PE and IUGR in the placental tissue. We have also confirmed as other studies that JAK-STAT pathway plays important role in PE, IUGR and GDM placental tissue.en_US
dc.identifier.citationEmirdar, V., Ekizceli, G., Dilber, Y., İnan, S., & Sancı, M. (2021). Immunolocalization of FOXP3, JAK1 and STAT5 in Preeclamptic, Intrauterine Growth Restricted and Gestational Diabetic Human Placentas. Aegean Journal of Obstetrics and Gynecology, 3(3), pp. 73-77. https://doi.org/10.46328/aejog.v3i3.101 ‌en_US
dc.identifier.doi10.46328/aejog.v3i3.101en_US
dc.identifier.endpage77en_US
dc.identifier.issue3en_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.46328/aejog.v3i3.101
dc.identifier.urihttps://hdl.handle.net/20.500.13055/118
dc.identifier.volume3en_US
dc.institutionauthorEkizceli, Gülçin
dc.language.isoenen_US
dc.publisherAbdurrahman Hamdi İnanen_US
dc.relation.ispartofAegean Journal of Obstetrics and Gynecologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPreeclampsiaen_US
dc.subjectIntrauterin Growth Restrictionen_US
dc.subjectEstational Diabetes Mellitusen_US
dc.subjectFOXP3en_US
dc.subjectJAK1 and STAT5 Receptorsen_US
dc.titleImmunolocalization of FOXP3, JAK1 and STAT5in preeclamptic, intrauterine growth restricted and gestational diabetic human placentasen_US
dc.typeArticleen_US
dspace.entity.typePublication

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