Ultrasound-assisted enhancement of bioactive compounds in hawthorn vinegar: A functional approach to anticancer and antidiabetic effects

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dc.authorid0000-0001-7354-9529
dc.authorid0000-0002-0185-0096
dc.authorid0000-0001-8694-0658
dc.authorid0000-0002-8726-3182
dc.authorid0000-0002-2817-5131
dc.authorid0000-0002-1884-1874
dc.authorid0000-0001-9840-4211
dc.contributor.authorÖğüt, Selim
dc.contributor.authorTürkol, Melikenur
dc.contributor.authorYıkmış, Seydi
dc.contributor.authorBozgeyik, Esra
dc.contributor.authorAbdi, Gholamreza
dc.contributor.authorKoçyiğit, Emine
dc.contributor.authorAadil, Rana Muhammad
dc.contributor.authorSeyidoğlu, Nilay
dc.contributor.authorKarakçı, Deniz
dc.contributor.authorTokatlı, Nazlı
dc.date.accessioned2025-01-27T18:26:19Z
dc.date.available2025-01-27T18:26:19Z
dc.date.issued2025
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Bilgisayar Mühendisliği Bölümü
dc.description.abstractIn this study, the effects of ultrasound treatment on bioactive components and functional properties of hawthorn vinegar (Crataegus tanacetifolia) were investigated. Parameters such as total phenolic compound (TPC), total flavonoid content (TFC), ascorbic acid (AA), DPPH radical scavenging activity and CUPRAC reducing capacity were optimised by surface response method (RSM) and 14 min duration and 61.40 % amplitude were determined as the most suitable treatment conditions. The results showed that ultrasound treatment improved the antioxidant properties of hawthorn vinegar by increasing TPC, TFC, DPPH and CUPRAC values. In addition, it was observed that hawthorn vinegar samples exhibited anticancer effects in cell culture experiments. In experiments on A549 (lung), MCF-7 (breast) and HT-29 (colon) cancer cell lines, ultrasound-treated vinegar increased apoptotic effects, suppressed cell migration and reduced necrosis rates in some cell lines. In particular, ultrasound treatment of vinegar resulted in a reduction in the expression of anti-apoptotic genes (BCL-2 and XIAP) and an enhancement in the expression of pro-apoptotic genes (BAX). These findings suggest that ultrasound technology preserves and enhances the bioactive components of hawthorn vinegar, improves its anticancer properties and increases its potential for use as a functional food product.
dc.identifier.citationÖğüt, S., Türkol, M., Yıkmış, S., Bozgeyik, E., Abdi, G., Koçyiğit, E., Aadil, R. M., Seyidoğlu, N., Karakçı, D., & Tokatlı, N. (2025). Ultrasound-assisted enhancement of bioactive compounds in hawthorn vinegar: A functional approach to anticancer and antidiabetic effects. Ultrasonics Sonochemistry, pp. 1-34. https://doi.org/10.1016/j.ultsonch.2025.107245
dc.identifier.doi10.1016/j.ultsonch.2025.107245
dc.identifier.endpage34
dc.identifier.issn1350-4177
dc.identifier.issn1873-2828
dc.identifier.pmidPMID: 39879805
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1016/j.ultsonch.2025.107245
dc.identifier.urihttps://hdl.handle.net/20.500.13055/903
dc.institutionauthorTokatlı, Nazlı
dc.institutionauthorid0000-0001-9840-4211
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofUltrasonics Sonochemistry
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectUltrasound Processing
dc.subjectHawthorn Vinegar
dc.subjectBioactive Compounds
dc.subjectAnticancer Properties
dc.subjectAntidiabetic Effects
dc.titleUltrasound-assisted enhancement of bioactive compounds in hawthorn vinegar: A functional approach to anticancer and antidiabetic effects
dc.typeArticle
dspace.entity.typePublication

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