Long-term effects of neural therapy in fibromyalgia – A retrospective multicenter analysis effectiveness of neural therapy in patients with fibromyalgia

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dc.authorid0000-0002-9427-9529
dc.authorid0000-0002-9746-5220
dc.authorid0000-0002-9746-5220
dc.authorid0000-0002-3464-853X
dc.authorid0000-0002-9886-2017
dc.authorid0000-0002-0931-3359
dc.authorid0000-0003-0754-0854
dc.contributor.authorUral Nazlıkul, Fatma Gülçin
dc.contributor.authorNazlıkul, Hüseyin
dc.contributor.authorÖzkan, Neslihan
dc.contributor.authorAcarkan, Tijen
dc.contributor.authorTamam, Yusuf
dc.contributor.authorOrak, Murat
dc.contributor.authorBilgin, Mehmet Dinçer
dc.date.accessioned2025-07-31T09:30:09Z
dc.date.available2025-07-31T09:30:09Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı
dc.description.abstractBackground: Fibromyalgia syndrome (FMS) is a chronic pain condition associated with widespread musculoskeletal discomfort, persistent fatigue, and diminished quality of life. Many patients show limited response to conventional treatments. Neural therapy (NT), a core modality of regulatory medicine, aims to restore autonomic balance and modulate inflammatory reflexes through targeted injections of local anesthetics. Objective: This retrospective multicenter study evaluates the long-term effectiveness of NT in 565 patients with treatment resistant fibromyalgia who previously failed to respond adequately to standard therapies. Methods: Data were collected from five neural therapy clinics between 2017 and 2024. Standardized outcome measures were assessed at baseline, immediately post-treatment, and at 3, 6, and 12 months: Pain intensity: Visual Analog Scale (VAS) Disease burden: Fibromyalgia Impact Questionnaire (FIQ) Quality of life: Short Form-36 (SF-36), including subdomains (physical function, pain, energy/fatique, social function, general health perception) Statistical analysis employed the Friedman test for repeated measures. Results: VAS scores dropped from a mean of 8.5 to 1.9 post-treatment and remained below 3.0 over 12 months. FIQ scores decreased from a baseline mean of 78.1 to 18.6 and remained significantly improved (mean 24.9 at 12 months). SF-36 physical function increased from 33.5 to 82.0, with sustained gains at all follow-ups. Social functioning, general health perception, pain and vitality domains showed similar sustained improvements. The treatment completion rate was 92.9%, indicating high tolerability and patient satisfaction. Conclusion: Neural therapy produced significant and sustained improvements in pain, physical functioning, energy, and social participation in fibromyalgia patients. Its multimodal effects—autonomic modulation, anti-inflammatory action, and improved microcirculation—support its use in integrative and regulatory pain medicine. This study presents strong evidence for neural therapy as an effective, safe, and cost-efficient option in patients with resistant fibromyalgia. Further randomized controlled trials are needed to confirm these findings and establish standard treatment protocols.
dc.identifier.citationUral Nazlıkul, F. G., Nazlıkul, H., Özkan, N., Acarkan, T., Tamam, Y., Orak, M., & Bilgin, M. D. (2025). Long-term effects of neural therapy in fibromyalgia – A retrospective multicenter analysis effectiveness of neural therapy in patients with fibromyalgia. International Clinical and Medical Case Reports Journal, 4(5), pp. 1-20.
dc.identifier.endpage20
dc.identifier.issn2832-5788
dc.identifier.issue5
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1053
dc.identifier.volume4
dc.institutionauthorUral Nazlıkul, Fatma Gülçin
dc.institutionauthorid0000-0002-9427-9529
dc.language.isoen
dc.publisherSalient Visionary Publications
dc.relation.ispartofInternational Clinical and Medical Case Reports Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeural Therapy
dc.subjectFibromyalgia
dc.subjectChronic Pain
dc.subjectAutonomic Regulation
dc.subjectRegulatory Medicine
dc.subjectSF-36
dc.subjectFIQ
dc.subjectVAS
dc.subjectLymphatic System
dc.titleLong-term effects of neural therapy in fibromyalgia – A retrospective multicenter analysis effectiveness of neural therapy in patients with fibromyalgia
dc.typeArticle
dspace.entity.typePublication

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