Effect of slow versus rapid advancement of enteral feeding on intestinal oxygenation in preterm infants

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dc.authorid0000-0002-4867-2514
dc.authorid0000-0003-3634-3243
dc.authorid0000-0003-2276-432X
dc.authorid0000-0002-7344-8637
dc.authorid0000-0002-1720-9711
dc.authorid0000-0003-2579-9480
dc.authorid0000-0002-5698-8930
dc.contributor.authorÖzdemir, Hülya
dc.contributor.authorKersin, Sinem Gülcan
dc.contributor.authorCan Buker, Halime Sema
dc.contributor.authorÇetinkaya, Merih
dc.contributor.authorKandemir, İbrahim
dc.contributor.authorMemişoğlu, Aslı
dc.contributor.authorBilgen, Hülya Selva
dc.date.accessioned2025-11-12T11:21:14Z
dc.date.available2025-11-12T11:21:14Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground/Objectives: The optimal rate of enteral feeding advancement in preterm infants remains uncertain despite decades of clinical research. This uncertainty arises from concerns that rapid feeding progression may increase the risk of feeding intolerance and necrotizing enterocolitis (NEC), two major causes of morbidity and mortality in this population. The feeding rate may also influence intestinal oxygenation due to mesen teric hemodynamic changes during feeding. This study aimed to evaluate whether the rate of enteral feeding advancement (slow vs. rapid) affects intestinal oxygenation and its association with feeding intolerance (FI) or necrotizing enterocolitis in very low birth weight preterm infants. Methods: This prospective, randomized, two-center study in cluded infants born at 28–32 weeks of gestation. Group 1 received slow advancement (20 mL/kg/day) and Group 2 rapid advancement (30 mL/kg/day) of enteral feeds. Splanchnic (srSO2) and cerebral (crSO2) oxygenation were monitored daily using the FDA approved INVOS NIRS device during feeding periods (08:00–16:00). Monitoring was per formed during minimal enteral nutrition (Phase 1), advancement phases (Phase 2), and for two days after achieving full enteral feeding (Phase 3). The splanchnic-to-cerebral oxygena tion ratio (SCOR) was also calculated. Percentage changes in srSO2 and SCOR during and after feeding were calculated from baseline (prefeeding) values and analyzed. Results: Sixty infants were enrolled. Mean gestational age and birth weight were 29.76 ± 1.33 weeks and 1375.05 ± 271.19 g, respectively. Group 2 achieved full enteral feeding significantly earlier (p = 0.001), with no other demographic differences between groups. No cases of NEC were observed. Feeding intolerance occurred in 14 infants (23.3%): 8 in Group 1 and 6 in Group 2 (p = 0.192). Both groups exhibited increased srSO2 and SCOR during feeding; however, the between-group differences were not statistically significant (Phase 2 srSO2 and SCOR: p = 0.07, 0.08; Phase 3 srSO2 and SCOR: p = 0.069, 0.071). However, the percentage change from baseline in srSO2 and SCOR during and after feeding was significantly greater in Group 2 during the advancement and full enteral feeding phases (Phase 2 srSO2 and SCOR: p = 0.03, 0.022; Phase 3 srSO2 and SCOR: p = 0.015, 0.048). Infants with feeding intolerance demonstrated significantly lower srSO2 and SCOR values compared to tolerant infants, and this reduction persisted even after reaching full enteral feeding. ROC analysis sug gested gestational age < 30 weeks, birth weight < 1180 g, srSO2 < 52, and SCOR < 0.6 were associated with feeding intolerance. Conclusions: Intermittent bolus feeding increased intestinal oxygenation, with a more pronounced effect in the rapid advancement group. No difference in gastrointestinal adverse outcomes was observed between groups. Lower in testinal oxygenation was associated with feeding intolerance, and the suggested predictive criteria may help guide individualized feeding strategies.
dc.identifier.citationÖzdemir, H., Kersin, S. G., Can Buker, H. S., Çetinkaya, M., Kandemir, İ., Memişoğlu, A. & Bilgen, H. S. (2025). Effect of slow versus rapid advancement of enteral feeding on intestinal oxygenation in preterm infants. Children, 12(11), pp. 1-15. https://doi.org/10.3390/children12111527
dc.identifier.doi10.3390/children12111527
dc.identifier.endpage15
dc.identifier.issn2227-9067
dc.identifier.issue11
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.3390/children12111527
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1184
dc.identifier.volume12
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorKandemir, İbrahim
dc.institutionauthorid0000-0002-1720-9711
dc.language.isoen
dc.publisherMDPI Publishing
dc.relation.ispartofChildren
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPreterm Infant
dc.subjectIntestinal Oxygenation
dc.subjectEnteral Feeding
dc.subjectSlow
dc.subjectRapid Advancement
dc.subjectFeeding Intolerance
dc.titleEffect of slow versus rapid advancement of enteral feeding on intestinal oxygenation in preterm infants
dc.typeArticle
dspace.entity.typePublication

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