İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
What is new in the 2025 APASL guidelines for metabolic dysfunction-associated fatty liver disease?
(AME Publishing Company, 2026) Pan, Ziyan; Örmeci, Necati; Chen, Jinjun; Ghazinian, Hasmik; Payawal, Diana; Eslam, Mohammed
As the global epidemics of obesity and type 2 diabetes mellitus (T2DM) continue to rise, metabolic dysfunction associated fatty liver disease (MAFLD) has become the most common chronic liver disease globally. The Asia-Pacific region is particularly affected, accounting for a significant majority of global liver-related deaths (1). To address this, the Asian Pacific Association for the Study of the Liver (APASL) has released updated clinical practice guidelines in 2025 (2). This article is a commentary focusing on the key changes and new recommendations within those guidelines, which were published in Hepatology International (2). Recognizing the limitations of the exclusionary diagnostic criteria for non-alcoholic fatty liver disease (NAFLD) and emphasizing the key role of metabolic dysfunction in disease pathogenesis, the introduction of the MAFLD definition in 2020 was a milestone in disease research and clinical practice (3-5). This shift reflects a significant evolution in our understanding of the disease, moving away from a diagnosis of exclusion towards one of inclusion based on metabolic dysfunction, recognizing the central role of metabolic factors and introducing the key concept of dual etiology, including alcohol consumption or coexisting liver diseases (6). Over the past 5 years, there have been significant advancements in understanding the disease, culminating in new knowledge, the first approved treatment, and the beginning of a new era of artificial intelligence (AI) with potential promise for hepatology. These changes stimulate the need for an updated document of the APASL guidelines for the diagnosis and management of MAFLD, which was recently released in 2025 (2). This updated guideline provides a comprehensive framework for addressing the growing burden of MAFLD in the Asia-Pacific region. This commentary aims to highlight the key aspects in this landmark document and touch on the main changes from the 2020 version (7).
Kardiyopulmoner resüsitasyon ve acil durumlarda sık kullanılan ilaçlar
(Ankara Nobel Tıp Kitabevleri, 2025) Askeroğlu, Araz; Güler, Hicran; Askeroğlu, Araz; Yavuz van Giersberge, Meryem
Yoğun bakımlarda yatan hastalarda hemodinamiğin stabil bir şekilde sürdürülmesi hedeflenir. Kardiyovasküler hastalıklar, hipovolemi, elektrolik dengesizlikleri, hipoksi, asidoz vb nedenlerden dolayı hemodinamik dengesizlik ve tedavi edilmediği takdirde kardiyaksolunum arrest meydana gelebilir. Kardiyak- solunum arreste ilişkin solunum ve dolaşımı sağlama ve hemodinamik dengeyi korumaya yönelik tıbbi araç gereçler birlikte bazı ilaçların kullanılması da gereklidir. Bu bölümde yoğun bakımda acil vakaların yönetiminde sıklıkla kullanılan ilaçlar, ilaç grupları, kullanım şekilleri, farmakokinetik-famakodinamik, etki mekanizması, endikasyonlar, kontrendikasyonlar, yan etkiler ve ilaçlara ilişkin hasta yönetiminde dikkat edilmesi gereken hususlar verilmiştir.
Waste toner particles based dispersive solid phase extraction for the trace determination of cadmium in cinnamon tea samples by flame atomic absorption spectrometry
(Elsevier, 2026) Ali, Büşra; Büyük, Muhammed Ali; Bayraktar, Ahsen; Serbest, Hakan; Bakırdere, Sezgin
This study presents a dispersive solid phase extraction (DSPE) protocol for the sensitive and accurate determi nation of trace levels of cadmium ions (Cd2+) by flame atomic absorption spectrometry (FAAS). Toner particles obtained from used printer cartridges were used as sorbent material for preconcentration of Cd2+ ions. Opti mization studies were performed univariately for the achievement of the highest extraction efficiency and the limit of detection (LOD) was found to be 0.55 µg L-1 under optimal operating conditions. By comparing the slopes of the linear plot equations for FAAS and waste toner-based DSPE-FAAS systems, the increase in sensitivity was calculated to be 40.9 times. The feasibility of the developed method was evaluated by spiking recovery studies on cinnamon tea samples and good recovery results between 90.4 % and 119.0 % determined by the matrix matching calibration strategy showed that the method is applicable to cinnamon tea and similar matrices.
NiO-SnO2 nanocomposite as an adsorbent for the preconcentration of manganese ions in chamomile tea extract
(Elsevier, 2026) Şaylan, Meltem; Gürsoy, Selim; Zaman, Buse Tuğba; Bakırdere, Sezgin
Matricaria chamomilla L., referred to as chamomile, is a well-known medicinal plant that is widely distributed throughout the world. In this study, a novel NiO-SnO2 nanocomposite- assisted preconcentration method was established for efficient extraction and separation of manganese ions from chamomile tea extract. This pre concentration method was coupled with flame atomic absorption spectroscopy (FAAS). NiO-SnO2 nano composites were synthesized using simple one-pot co-precipitation procedure and calcined at 650 ◦C to obtain nanoparticles with sizes below 100 nm. X-ray diffraction (XRD) analysis indicated that the crystallite size of NiO SnO2 nanocomposites was estimated to be 46.03 nm using the Monshi–Scherrer equation. The LOD (limit of detection) and linear working range were determined as 3.6 μg/L and 10–100 μg/L, respectively. The proposed method was successfully validated, and recoveries ranged from 87.2 %–117.0 %. NiO-SnO2 nanocomposites represent a promising low-cost adsorbent for the preconcentration and subsequent determination of other heavy metal ions in diverse herbal extracts.
Feeding the mind: Preliminary insights into the effects of anthocyanin-rich extract from black carrots on brain activity and gut microbiota in patients with cognitive impairments
(Nature Research, 2025) Müdüroğlu Kırmızıbekmez, Aynur; Önder, Alparslan; Özdemir, Mustafa Yasir; Gürerk, Gamze; Aydın, Sevcan; Eryiğit, Önder Yüksel; Güloğlu, Mehmet Oktar; Kara, İhsan
Anthocyanins, known for their antioxidant and anti-inflammatory properties, have been associated with cognitive benefits, potentially mediated by gut-brain axis interactions. This study investigates the effects of a 12-week Anthocyanin-Rich Extract (ARE) intervention on brain activity and gut microbiota composition in older adults with neurocognitive impairments. In this study, 50 participants underwent electroencephalography (EEG) recordings and gut microbiota analyses before and after the intervention. EEG data were analyzed using connectivity and entropy metrics across multiple frequency bands. Gut microbiota composition was assessed via 16S rRNA sequencing to evaluate taxonomic shifts. Results revealed increased EEG connectivity, particularly in alpha, beta, and gamma frequency bands, suggesting improved neural communication and complexity following ARE consumption. Significant changes in nonlinear EEG metrics were observed, consistent with previous findings in the literature. Microbiota analysis indicated non-significant alterations in overall diversity but revealed increases in Alistipes, Streptococcus thermophilus, and Flavonifractor, alongside a decrease in Hungatella, potentially implicating SCFA metabolism and inflammatory regulation. These findings suggest ARE may enhance cognitive health by modulating neural activity and gut microbiota composition. While these results provide preliminary evidence of neuroprotective effects, further research with larger, disorder-specific cohorts and placebo-controlled designs is necessary to validate outcomes and explore gut-brain axis mechanisms in cognitive decline.
