İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Can neoadjuvant chemoradiotherapy be omitted in cT2N+ and cT3 mid-rectal cancer: Protocol for a prospective, observational, cohort study (CANO)
(Public Library of Science, 2025) Karakayalı, Feza; Arslan, Çiğdem; Bisgin, Tayfun; Erenler Bayraktar, İlknur; Bayraktar, Onur; Canda, Aras Emre
Background Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision (TME) is the standard treatment for locally advanced rectal cancer. However, nCRT is associ ated with significant morbidity, impacting patients’ quality of life. Recent advancements in MRI-based risk stratification have raised the possibility of omitting nCRT in selected patients without compromising oncologic outcomes. This study aims to evaluate whether upfront TME alone achieves similar 3-year disease-free survival compared to the standard approach of nCRT followed by TME in patients with cT2N+ and cT3Nx mid-rectal cancer without MRI-based high-risk features regarding local recurrence. Methods The CANO trial is a prospective, multicenter, observational cohort study involving 436 patients across Türkiye. Eligible patients will be classified into two groups: those undergoing direct TME and those receiving nCRT followed by TME. The primary endpoint is 3-year disease-free survival (DFS), with secondary outcomes including 5-year DFS, overall survival, local recurrence rates, and quality of life assessments using validated questionnaires. Data will be prospectively collected and monitored by the steering committee with predefined interim analyses. Discussion The CANO trial addresses the ongoing debate regarding selective omission of nCRT in low-risk mid-rectal cancer. By leveraging MRI-based risk stratification and PLOS One | https://doi.org/10.1371/journal.pone.0321819 November 5, 2025 2 / 11 a collaborative national network, the study aims to provide high-quality evidence supporting a more personalized treatment approach. The findings have the potential to reduce treatment-related morbidity without compromising oncologic safety, contrib uting to the refinement of current guidelines.
LC-MS/MS methods for the determinatıon of paclitaxel in biological fluıds: A review
(Gece Kitaplığı, 2025) Şenol, Mahmut Raşit; Sağlık Aslan, Serap
Oncology stands out as a dynamic field of science, driven by contin uous development and innovative research leading to advances in treat ment methods. In this context, paclitaxel is a chemotherapy drug that is effectively used in the treatment of a wide variety of cancer types. The drug’s areas of application include breast, ovarian, bladder, lung, prostate, melanoma, oesophageal cancers, Kaposi’s sarcoma, and various other solid tumours. This review details paclitaxel’s therapeutic indications, its mechanism of action at the cellular level, its role in suppressing tumour cell proliferation, as well as dosage adjustments, infusion protocols, routes of administration, and possible contraindications; it also emphasises the clinical importance of monitoring patients undergoing treatment. Pacli taxel, initially known as “taxol” when it was first discovered, is a natural diterpenoid compound derived from the Pacific yew tree (Taxus brevifo lia). The drug’s discovery was the result of natural product screening pro grammes conducted by the National Cancer Institute (NCI) in the United States in the late 1960s and early 1970s. During this process, research ers examined various plant extracts in an effort to identify compounds with anticancer potential, and paclitaxel’s pronounced cytotoxic effects attracted attention. In particular, its capacity to halt the cell cycle and induce apoptosis by inhibiting microtubule depolymerisation has made paclitaxel a priority agent in anticancer research (1).
Gender-specific foot morphology and biomechanical patterns in young adults: A combined photogrammetric and plantar pressure analysis
(Springer Nature Link, 2025) Nteli Chatzioglou, Gkionoul; Govsa, Figen; Bedre, Özden; Pınar, Yelda; Hepgüler, Simin
Purpose Understanding gender-based foot morphological differences is critical for ergonomic footwear design. This study investigated these variations in young adults using photogrammetric and plantar pressure analysis. Methods We analyzed 200 healthy participants (100 males, 100 females; aged 19–21 years) through digital photogrammetry and RSscan Footscan pressure mapping. Key parameters included foot length (FL), ball width (BWF), hallux valgus angle (HVd), lateral foot angle (LdF), and Clarke’s Index for arch classification. Plantar pressure distribution was assessed across 10 anatomical zones. Results We revealed significant gender disparities: males had longer (26.6 vs. 25.2 cm) and wider feet (10.2 vs. 9.1 cm), while 75% of participants exhibited HVd (5.1°–6.3°), with no gender difference. Dynamic Clarke’s Index showed 80% had high arches, correlating with lower BMI (p<0.001). Pressure analysis highlighted higher midfoot loading (37.8–41.2 cm2 ) and medial forefoot pressure in HVd cases. Females predominantly wore smaller shoes (sizes 36–38), whereas 89% of males wore sizes 42–44. BMI influenced midfoot pressure (r=0.3) and arch height, with flat arches linked to higher BMI. Foot asymmetry (38%) and HVd prevalence underscored the need for gender-specific shoe designs. Conclusion It emphasize prioritizing ergonomic footwear to mitigate pressure imbalances, HVd progression, and asym metry, particularly in high-BMI individuals. This dual-method approach provides actionable insights for biomechanical applications and footwear customization.
Development and validation of an HPLC method for quantification of solifenacin in spiked human breast milk
(Korean Society of Analytical Sciences, 2025) Ceylan, Burhan; Çayci, Meltem; Önal, Cem; Önal, Armağan
An efficient and reliable reversed phase high performance liquid chromatography (HPLC) method was established and validated for the quantitative analysis of solifenacin succinate in fortified human breast milk samples. Chromatographic separation was carried out on a C18 column (150 × 4.6 mm, 5 μm particle size) and a isocratic mobile phase composed of acetonitrile and phosphate buffer (pH 3.5) in a 65:35 (v/v) ratio. The flow rate was at 1.1 mL/min, and detection was performed at 225 nm using a ultraviolet (UV) detector. The method exhibited excellent linearity in the range of 1.0 to 40.0 ng/mL (r² = 0.9999). The validation process was performed in accordance with European Medicines Agency (EMA) bioanalytical guidelines, and included selectivity, accuracy, precision, sensitivity, recovery, robustness, and stability assessments. The liquid-liquid extraction (LLE) procedure used for sample pretreatment provided satisfactory recovery (mean: 99.32 %) and minimized matrix interferences from breast milk. The method showed high reproducibility, did not require an internal standar, and offered a rapid analysis time of approximately 3.4 minutes. This study offers a simple, cost-effective, and sensitive HPLC-UV method for monitoring solifenacin levels in breast milk matrices, providing a valuable tool for evaluating drug safety during lactation.
Exploring cervical vestibular evoked myogenic potential responses to different stimuli at different frequencies
(Karger, 2025) Karababa, Ercan; Özdemir Aktaş, Betül; Akın Öcal, F. Ceyda; Satar, Bülent
Objetive: This study aimed to compare cervical vestibular evoked myogenic potentials (cVEMP) elicited by Tone Burst (TB) and Narrow Band Level-Specific Chirp (NB LS-CE Chirp) stimuli at 500, 1000, 2000, and 4000 Hz in healthy individuals. Methods: Thirty-two healthy participants (15 females, 17 males; mean age: 24.59 ± 1.93 years) underwent otoscopic examination, pure-tone audiometry, and cVEMP testing at 95 dB nHL using TB and NB LS-CE Chirp stimuli. P1 latency, N1 latency, and P1N1 amplitude were recorded. Results: At 500 Hz, both stimuli elicited responses in all subjects. Significant differences in P1 latency, N1 latency, and P1N1 amplitude were found between the stimuli at 500 and 1000 Hz (p <0.05). No significant differences were observed at 2000 and 4000 Hz (p> 0.05). Conclusion: NB LS-CE Chirp stimuli generate larger and earlier cVEMP responses than TB stimuli, particularly at lower frequencies, suggesting higher effectiveness for saccular assessment.
