İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Labia majora lifting technique with polydioxanone threads
(Oxford University Press, 2025) Ağlamış, Savaş Özgür; Akkaya, Selver Kübra; Şahin, Elif; Şahin, Hanifi
Background: Polydioxanone (PDO) thread is a synthetic absorbable surgical suture used for rejuvenation and lifting. Aim: The aim of this study is to use PDO threads for rejuvenation and enlargement effect in patients with labium majus hypotrophy. Methods: Twenty-one patients with labia majora hypotrophy were included in the study. Conventionally, surgery, fat filling or hyaluronic acid filling is used for labia majora rejuvenation. In this study, a different technique, the PDO thread suspension technique, was applied. For PDO thread, Hyundae Meditech Co.Ltd’s Secret Line Up product containing 50 mm screw thread with 30 G-38 mm needle tip was used. It was planned to use 10 PDO threads for right and left labia majora. After a total of 20 needles were inserted, the needles were removed one by one and the PDO threads remained in the subcutaneous superficial layer and the procedure was terminated 5 min later. Preoperative and postoperative the Female Genital Self-Image Scale (FGSIS) scores of the patients were compared. Outcomes: The overall FGSIS total score demonstrated a significant increase following the intervention. Results: The FGSIS total mean score in the preoperative period was increased in the postoperative period. This difference was statistically significant. Moreover, the mean score calculated for each parameter of FGSIS in the preoperative period increased significantly in the postoperative period. Clinical Implications: These findings indicate a favorable safety profile for the use of PDO threads in this clinical context. Strengths and Limitations: The strength of the study is to introduce a minimally invasive and effective method for labia majora lifting, on the other hand, the small number of patients in the study, limitation of the study. Conclusion: We would like to point out that in this study, we evaluated labium majus rejuvenation from the same perspective, based on the shaping and enlargement of genital appearance and its positive effect on self-confidence and increase in sexual functions. Unlike many labium majus rejuvenation procedures, this less invasive procedure has achieved similar results. In this context, it is a preferable alternative to surgery.
Discovery and biological validation of a novel small-molecule inhibitor of Drp1-mediated mitochondrial fragmentation
(Wiley, 2025) Ateşoğlu, Sibel; Bardakçı, Enes; Baday, Saja Jawad Shnaishel; Budak, Gülden; Bektaş, Meryem; Akçakaya, Handan; Hacıosmanoğlu Aldoğan, Ebru; Dal Yöntem, Fulya
Discovery and biological validation of a novel small-molecule inhibitor of Drp1-mediated mitochondrial fragmentation.
A natural therapeutic approach to fibrocystic breast disease: Antiproliferative effects of phenolic cocktail and metformin on a fibrocystic breast cell line model
(Wiley, 2025) Sag, Matej; Pehlevan Karabıyık, Funda; Ceviz Çubukçuoğlu, Ayşe Begüm; Aydoğan, Çağatay; Malikova, Fidan; Yalım, D.; Özkara, Gamze Akın; Öztürk, Özmen
A natural therapeutic approach to fibrocystic breast disease: antiproliferative effects of phenolic cocktail and metformin on a fibrocystic breast cell line model.
Dose-dependent effects of boron exposure on locomotor activity and oxidant-antioxidant status in zebrafish
(Wiley, 2025) Özel Korlu, Armağan Begüm; Beler, Mahmut; Eğilmezer, Gizem; Mızrak, Zülal; Akkuş, Efruz İrem; Ünal, İlay Sema
Dose-dependent effects of boron exposure on locomotor activity and oxidant-antioxidant status in zebrafish
Effects of a polyphenolic chemical mixture on the apoptotis pathway of a triple negative breast cancer cell line
(Wiley, 2025) Eronat, Allison Pınar; Ceviz Çubukçuoğlu, Ayşe Begüm; Özkara, Gamze Akın; Yılmaz Aydoğan, Hülya; Öztürk, Özmen
Effects of a polyphenolic chemical mixture on the apoptotis pathway of a triple negative breast cancer cell line.
