İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
LC-MS/MS analyses of free and nanoparticle loaded doxorubicin a review
(Gece Kitaplığı, 2026) Yapıcı, Buse; Sağlık Aslan, Serap; Dayangaç, Alparslan; Şahna, Engin; Akgül, Hasan
Cancer remains one of the primary health concerns worldwide, leading in morbidity and mortality rates. In chemotherapy, doxorubicin (DOX) serves as a first-line agent in the treatment of lymphomas, leukemias, Kaposi's sarcoma, and various solid tumors. Doxorubicin is an anthracycline derivative antibiotic isolated from the bacterium Streptomyces peucetius.
Retroaponeurotic repair technique in ventral hernia and rectus diastasis
(Türkiye Klinikleri Yayınevi, 2026) Eröz, Erhan; Şenol, Metin; Altıntoprak, Fatih; Akın, Emrah
This chapter examines the Preaponeurotic Endoscopic Repair (REPA) technique for treat ing rectus diastasis and concomitant ventral hernias. Performed in the subcutaneous plane without en tering the peritoneal cavity, this minimally invasive method is detailed through steps including trocar placement, diastasis plication, and onlay mesh application. Literature indicates that REPA offers re duced postoperative pain and faster recovery compared to abdominoplasty, though it is indicated for pa tients without significant skin laxity. The chapter highlights the higher risk of seroma compared to retromuscular techniques (eTEP) and the importance of postoperative drainage. Consequently, REPA is presented as a safe and effective technique that restores abdominal wall integrity while minimizing visceral injury risks.
Exergy, exergoeconomic, environmental damage cost, and performance-emissions trade-off analysis of two-stroke UAV engine operating with phytol and benzene fuel additives
(Elsevier, 2026) Gülcan, Halil Erdi; Demir, Usame; Özer, Salih; Tunçer, Erdal
Two-stroke Unmanned Aerial Vehicle (UAV) engines offer high power-to-weight ratios but present challenges in fuel efficiency and environmental impact. This study comparatively investigates the effects of phytol, a bio-based oxygenated diterpene alcohol, and benzene, an aromatic hydrocarbon, on the performance, exergy, exer goeconomic characteristics, and exhaust emissions of a two-stroke UAV engine. Experiments were conducted at five engine speeds (3250–6250 rpm) using gasoline blended with 10% and 20% phytol (P10, P20) or benzene (B10, B20) by volume. The experimental results were evaluated through an integrated assessment combining exergy analysis, Specific Exergy Costing (SPECO), and calculations of environmental impact and damage costs based on measured gaseous pollutants. Compared with reference gasoline, P20 increased exergy destruction by an average of 8.4% and decreased exergy efficiency by 6.8%, whereas B20 increased exergy destruction by 3.6% and reduced exergy efficiency by 3.0%. Despite these thermodynamic results, P10 reduced the calculated total environmental impact by an average of 1.2%, while B20 increased it by 3.3%. The calculated environmental damage costs decreased for all investigated additive blends within the adopted pollutant valuation framework. However, the high commercial purchase price of phytol adversely affected its exergoeconomic performance. These findings highlight important trade-offs between thermodynamic efficiency, fuel-related economic costs, and exhaust emission-related environmental indicators. The results provide a comparative experimental basis for further investigation of alternative fuel additives in lightweight UAV engines.
Adenomyosis and uterine fibroids: Two distinct yet overlapping clinical entities
(MDPI Publishing, 2026) Pecorella, Giovanni; Morciano, Andrea; Medvediev, Mykhailo; Sparic, Radmila; Bıyık, İsmail; Aydın, Gerçek; Baldini, Giorgio Maria; Malvasi, Antonio; Stojković, Marta; Tinelli, Andrea
Adenomyosis and uterine fibroids are among the most common benign uterine disorders in women of reproductive age and represent major causes of abnormal uterine bleeding, pelvic pain, and infertility. Despite their distinct histopathological features, they frequently coexist and share several hormonal and molecular mechanisms, making diagnosis and treatment challenging. This narrative review examines the current evidence on their epidemiology, pathophysiology, clinical presentation, imaging characteristics, reproductive impact, and therapeutic management, with particular attention to the role of imaging in the differential diagnosis and management of coexisting disease. A non-systematic narrative review of the literature was conducted using PubMed/MEDLINE and Scopus. Relevant original studies, systematic reviews, meta-analyses, consensus statements, and clinical guidelines addressing adenomyosis, uterine fibroids, imaging, fertility, and treatment were considered. Additional references were identified through manual screening of the bibliographies of the retrieved articles. Although adenomyosis and uterine fibroids differ in their biological origin and morphological appearance, they commonly present with overlapping symptoms, including heavy menstrual bleeding, dysmenorrhea, chronic pelvic pain, and reproductive dysfunction. Transvaginal ultrasound remains the first-line imaging modality, whereas magnetic resonance imaging is particularly valuable in complex cases, lesion characterization, and preoperative assessment. Accurate imaging phenotyping may help distinguish isolated from coexisting disease and support individualized medical, surgical, or minimally invasive treatment planning. A structured imaging-based approach integrated with clinical findings and reproductive goals may improve disease characterization and support individualized management of adenomyosis and uterine fibroids. Further standardization of imaging criteria and validation of emerging diagnostic technologies may improve patient stratification and treatment selection.
On the effectiveness of the weighted least squares technique for urban scaling: Empirical evidence on the relationship between labor productivity and city size in the u.s., europe, and latin america
(Springer Nature Link, 2026) Dingeç, Kemal Dinçer; Börü, Furkan; Tahsin, Emine
The cities are the places where scale economies are created. Therefore economics of agglomeration is important to understand different aspects of urbanization. The principles of agglomeration economies can be quantified by scaling analysis. The standard statistical method for scaling analysis is simple linear regression (ordinary least squares). However, the special characteristics of city data such as non-normal ity and non-constant variance (heteroskedasticity) complicate the statistical estima tion and make it necessary to use special estimation techniques. In this paper, to overcome these problems, the standard approach of utilizing the classical weighted least square technique is suggested. The novelty of the paper is the derivation of a specific weighting rule starting from a lognormal model of the individual-level metric. We applied the ordinary least squares (OLS) and the weighted least squares (WLS) technique for the investigation and comparison of the scaling behaviors of labor productivities in the cities of three different regions (Latin America, Europe, and the USA). It is revealed that while in the US and Europe OLS and WLS yield similar results, the OLS is incapable of detecting the scaling behavior in Latin America. The WLS is capable of identifying the “increasing return to scale” rela tionship between city size and labor productivity.
