İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Güncel Gönderiler
Influence of drying methods on redispersibility and dissolution of canagliflozin nanocrystals: A comparative approach
(MDPI Publishing, 2026) Pirinçci Tok, Yağmur; Demiralp, Burcu; Güngör, Sevgi; Sarıkaya, Ali Osman; Aldeniz, Emre Erol; Dude, Udaya Kumar; Özsoy, Yıldız
Background/Objectives: Canagliflozin (CFZ) is the first sodium glucose co-transporter 2 (SGLT-2) inhibitor and is characterized by poor water solubility and permeability, resulting in low oral bioavailability. In this study, a CFZ nanosuspension (CFZ-NS) was converted into a solid form to improve the physical stability of CFZ nanocrystals (CFZ-NCs) and to enable formulation as a tablet dosage form. Methods: To achieve adequate redispersibility of dried CFZ-NCs, fluid bed granulation and spray-drying methods were employed, and the effects of critical process parameters were investigated. The stability of spray dried nanocrystal tablets (NCs-SD-TAB) was evaluated over a three-month period under storage conditions of 25 ± 2 ◦C with 60 ± 5% relative humidity (RH) and 40 ± 2 ◦C with 75 ± 5% RH. Results: The highest redispersibility index (94%) was obtained using the spray-drying method. Tablets prepared with spray-dried NCs-SD-TAB exhibited a significantly higher in vitro dissolution rate under non-sink conditions compared with control tablets prepared using unprocessed CFZ with the same excipients, as well as the marketed product. NCs-SD-TAB showed an approximately three-fold increase in drug release at 15 min in 0.1 N HCl, with a pH 4.5 acetate buffer and pH 6.8 phosphate buffer, which simulate gastrointestinal pH conditions, relative to the marketed product. Conclusions: Overall, these results indicate that nanocrystal technology represents a promising approach for CFZ as an improved oral drug-delivery system, primarily due to its solubility enhancement capabilities.
Energy production from gas hydrates
(Elsevier, 2025) Çifci, Günay; Parlaktuna, Mahmut; Çelebi, Serdar Suut; Okay Günaydın, Seda
Gas hydrates are a type of natural formation that contains large amounts of mostly methane, which is also known as natural gas, and water, in the form of ice. Methane hydrates are cages of water molecules that surround and trap methane molecules. Gas hydrate is geophysical, geologically and economically important for several reasons: Gas hydrates are good cap rocks for oil and natural gas. The methane hydrate itself is an important energy source. A volume of gas hydrate can store up to 164 times per volume of gas as zipped gas, and the fact that gas hydrate occurs almost all around the world. Methane seepage may indicate the existence of a deeper hydrocarbon reservoir, and the methane production and migration in the slope sediments may cause massive slope failure. Last but not least Methane gas has a minimum 22 times more global warm absorption capacity compared to carbon dioxide if it is released into the atmosphere. In other words, greenhouse gas is due to its contribution to climate change. Gas hydrates have drawn significant interest as a potential near future energy resource. Research in the production field of gas hydrates has focused on several key areas, including the feasibility of commercial production, the environmental impacts, and the technological improvements associated with the safe recovery of gas.
Comparison of quadro‑iliac plane block and erector spinae plane block for postoperative analgesia management after single level lumbar discectomy surgery: A randomized, double‑blind, controlled, prospective, multicenter study
(Springer Nature Link, 2025) Turan, Engin İhsan; Otlu Bıyıkoğlu, Büşra; Özen, Volkan; Alver, Selçuk; Umutoğlu, Tarık; Cücü, Oğuzhan; Çevik, Serdar; Çiftçi, Bahadır; Şahin, Ayça Sultan
Purpose Effective postoperative analgesia management is critical for optimizing recovery and patient satisfaction following lumbar discectomy. Erector Spinae Plane Block (ESPB) is an established regional anesthesia technique with proven efficacy, while the novel Quadro-Iliac Plane Block (QIPB) has shown promise as an alternative approach. This study compares the analgesic efficacy, opioid-sparing potential, and safety of ESPB and QIPB in single-level lumbar discectomies. Method This multicenter, prospective, randomized, double-blind study included 60 patients aged 18–65 years undergoing single-level lumbar discectomy. Patients were randomized into ESPB (n=30) and QIPB (n=30) groups. Both blocks were performed at the end of surgery, before the extubation under ultrasound guidance using 40 ml (0.25%) bupivacaine bilater ally. The primary outcome was postoperative pain assessed by the Numeric Rating Scale (NRS) at 12 h. Secondary outcomes included tramadol consumption, rescue analgesia requirements, hemodynamic parameters, and adverse events. Results The primary outcome, 12-h NRS scores, did not differ significantly between groups (p>0.05), indicating similar anal gesic efficacy. Secondary outcomes—including total tramadol consumption (54.00±49.03 mg for ESPB vs. 44.67±44.16 mg for QIPB, p=0.476), need for rescue analgesia, and incidence of nausea and vomiting—were also comparable. No motor block was observed in either group. Conclusion Although QIPB did not demonstrate superiority over ESPB, it was found to be not inferior in analgesic effect and safety outcomes. These findings suggest that QIPB may be a reliable alternative to ESPB in lumbar discectomy procedures.
Impulsivity in parkinson’s disease
(Wolters Kluwer, 2026) Değirmenci, Yıldız; Altınbaş, Kürşat; Keçeci, Hulusi; Bougea, Anastasia; İsmayılov, Rashad; Gourzis, Philippos
Introduction/Aims: Parkinson’s disease (PD) is a neurodegenerative disease characterized by cardinal motor and nonmotor symptoms. Impulse control disorders are common neuropsychiatric manifestations in patients with PD (pwPD) under dopaminergic therapy. However, impulsivity is an underestimated symptom. Hence, the present study aimed to evaluate the impulsivity in pwPD. Methods: Forty‑seven adults who were diagnosed with having PD according to the Queen Square Brain Bank criteria for PD diagnosis and 30 age‑matched healthy controls were enrolled in the study. The sociodemographic data of the study participants and disease characteristics of the patients were recorded. All participants completed the Barratt impulsiveness scale (BIS). BIS scores were statistically analyzed between the groups. Results: The results revealed no significant differences between the patients and controls in terms of age (P > 0.05) or sex (P > 0.05). The total BIS scores were higher in the PD group than in the healthy controls (t = 2.1, P = 0.038). The items of BIS and attentional impulsivity scores were higher in the pwPD than in the controls (t = 2.8, P = 0.005), but there were no statistically significant differences between the groups in terms of motor and nonplanning impulsivity (z = 1.8, P = 0.07; and t = 1.1, P = 0.31, respectively). Discussion: Our results indicate that attentional impulsivity is an important clinical characteristic of pwPD, even in the absence of impulse control disorders. Conclusion: Further studies are required to confirm these findings in view of personalized PD treatment.
Management of plastic wastes: History, current applications, and future perspectives of recycling, upcycling, and reclaiming technologies
(Springer Nature Link, 2026) Alanalp, Mine Begüm; Ergin, Mustafa Fatih; Durmuş, Ali; Das, Alok Prasad; Karakuş, Selcan
Plastic materials possess a variety of structural and physical features and some key characteristics that make them widely used in many applications due to their superior properties such as low density, chemical and mechanical durability, low cost, recyclability, easiness and versatility in processing, thermal and electrical insulating property, colorability. Plastics are used in various applications in many industrial areas and daily-life, including packaging (the largest segment), construction, automotive, electronics, and consumer goods. Since the 1950s, production and consumption of plastics has readily increased, with global production reaching over 370 million metric tons in recent years. This trend is expected to continue, with projections estimating it could reach over 1 billion metric tons by 2030. The highest plastic consumption is found in developed regions like North America, Europe, and parts of Asia. However, emerging economies are rapidly increasing their consumption related to growing industrialization and urbanization in these countries. Overall, while plastics play a crucial role in modern society, their increasing consumption raises important questions about sustainability and environmental health. The rapid increase in plastic production and consumption has led to significant environmental challenges such as pollution, wildlife harm, and waste management issues. An estimated 11 million metric tons of plastic enter the oceans each year. There is a growing push toward a circular economy model, emphasizing the importance of reducing, reusing, and recycling plastics to minimize environmental impact. Managing plastic wastes effectively involves a combination of various strategies aimed at reducing, reusing, recycling, and disposing of plastics in an environmentally responsible manner. Modern societies can significantly reduce plastic waste and its environmental impact, promoting a more sustainable future by integrating these strategies. This chapter comprehensively summarizes and discusses the current applications of recycling, upcycling and reclaiming technologies of plastic wastes. Future perspectives and projections will also be highlighted to manage plastic wastes effectively and establish sustainable development in the world.
