İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Hereditary breast, ovarian, pancreatic and prostate cancer syndrome: Multigene testing, multiomics, and risk management
(Türk Radyasyon Onkolojisi Derneği, 2025) Dinç, Ahmet; Yazıcı, Hilal; Yazıcı, Hülya
Hereditary breast, ovarian, pancreas and prostate cancer (HBOC/HBOPC) syndromes remain a major global health concern, with BRCA1, BRCA2 and other high- or moderate-risk homologous recombi nation repair (HRR) gene variants driving a significant share of familial cancer risk. Beyond breast and ovarian sites, these mutations increase susceptibility to prostate, pancreatic, and other solid tumors, high lighting the syndromic nature of HBOPC. Advances in multigene panel testing (MPT), AI-supported variant classification, and polygenic risk scores (PRS) now enable more precise risk estimation, while functional reclassification and population-specific founder mutation mapping reduce uncertainty in un derrepresented groups. Emerging epigenetic and non-coding RNA biomarkers further strengthen early detection and treatment stratification. However, large-scale validation is still needed to translate these tools into equitable care. Risk-reducing surgeries, tailored surveillance, and targeted therapies—includ ing PARP inhibitors, immunotherapy, and homologous recombination deficiency (HRD)-based regi mens—have transformed management but require equitable access and culturally sensitive counseling to address psychosocial barriers and family communication challenges. Real-world data (RWD) and cross border variant databases are essential to bridge gaps between guidelines and practice, especially where founder effects and mosaicism complicate standard criteria. This review integrates current evidence on the genetic and molecular foundations, organ-specific management, evolving therapies, and ethical di mensions of HBOPC care. By combining multidisciplinary insights with AI, functional analyses, and real-world implementation strategies, this review highlights how next-generation precision oncology can deliver equitable, high-quality, and locally adapted prevention and treatment for families worldwide.
Anatomical evaluation of supraorbital notch and supraorbital foramen morphology and supraorbital nerve distribution: A cadaveric study
(Medip Academy, 2025) Yıldız, Nilay; Nteli Chatzioglou, Gkionoul; Gayretli, Özcan
Background: Peripheral nerve compression at trigger points is considered a cause of migraine and primary headaches. These trigger points are most commonly found in the sensory regions. In particular, compression of the supraorbital nerve by fascial bands or at the supraorbital foramen has been reported as a source of headache in the literature. This study aimed to evaluate the structures through which the supraorbital nerve passes to reach the innervation area. Methods: Eleven female and 11 male cadaver heads fixed with formalin were dissected and the formation of the supraorbital nerve emerging the cranium was evaluated. Results: Cadaveric sides were divided into four types based on the presence of a notch or foramen. Sides with only one notch constituted the majority at 45.4% (Type A). Conclusions: In this study, in cases with only supraorbital notch, the distance of the notch to the midsagittal line was found to be 23.51±3.74 mm on the right side and 22.77±3.75 mm on the left side on average. In cases with only supraorbital foramen, the right side average was calculated as 20.50±4.30 mm and the left side average was calculated as 25.60±3.83 mm. These measurements are of considerable importance in procedures such as migraine botox or migraine surgery.
Surgical anatomy of the anterior choroidal artery: Complex morphometry and morphological analysis of its origin and relations
(Springer Nature Link, 2025) Kaçur, İdil; Nteli Chatzioglou, Gkionoul; Nas, Emine; Coşkun, Osman; Gayretli, Özcan
Background The anterior choroidal artery (AChA) and posterior communicating artery (PComA) are critical vessels with significant anatomical variations. Detailed knowledge of their morphometry and origin is essential for neurovascular surgery and understanding cerebrovascular pathology. Methods This study was conducted on 62 fresh cadavers (124 hemispheres). The external diameters of the internal carotid artery (ICA) and PComA were measured. The AChA was clas sified based on its origin: Type 1 (from the ICA), Type 2 (from the ICA bifurcation), or Type 3 (from the PComA). The distance from the AChA origin to the PComA origin was measured for each type. The circumferential origin of the AChA from the ICA was also documented. Results The mean external diameter of the ICA was 3.77±0.77 mm. The proximal, middle, and distal external diameters of the PComA were 1.01±0.49 mm, 0.97±0.48 mm, and 0.90±0.45 mm, respec tively, with a mean length of 14.82±4.74 mm. The AChA originated from the ICA (Type 1) in 76.9% of hemispheres, from the ICA bifurcation (Type 2) in 21.4%, and from the PComA (Type 3) in 1.7%. The distance between the AChA and PComA origins differed significantly between types, being greatest for Type 2 (4.73±1.16 mm) compared to Type 1 (3.98±1.23 mm) (p=0.001). The AChA most commonly arose from the posterior wall of the ICA (84.68%). Conclusion This study provides detailed morphometric data on the AChA and PComA in a Turkish/Caucasian population, revealing a notably high prevalence of the AChA originating from the ICA bifurcation. The significant difference in the AChA-PComA distance based on the origin type may have important implications for surgical planning and hemodynamic modeling, underscoring the clinical relevance of these anatomical variations.
Energy, exergy and exergoeconomic analysis of a CI engine fuelled with waste frying oil biodiesel blended with waste tyre pyrolysis oil and higher alcohols (Heptanol and Octanol): A waste-to-energy approach
(Elsevier, 2025) Gülcan, Halil Erdi; Demirci, Oğuz Kürşat; Erol, Derviş; Tunçer, Erdal
This study evaluates a waste-to-energy diesel concept that co-valorises waste cooking oil and end-of-life tyres by formulating biodiesel–tyre pyrolysis oil blends with small additions of higher alcohols (1-heptanol and n-octa nol). Five fuels (B100, B90T10, B85T10H5, B85T10O5 and B80T10H5O5) were tested in a single-cylinder diesel engine. Engine performance, emissions and combined energy–exergy–exergoeconomic indicators were used to assess thermodynamic and economic viability. The quaternary blend B80T10H5O5 achieved the highest mean energy and exergy efficiencies (26.5 % and 24.6 %) and reduced brake-specific fuel consumption by about 5 % relative to neat biodiesel, owing to improved volatility and fuel oxygenation. This benefit was accompanied by higher NOx emissions and the largest specific exergy cost (≈1430 USD GJ− 1 ) at full load. By contrast, the binary blend B90T10 preserved biodiesel-like efficiency while lowering the specific exergy cost of shaft power by roughly 10 %, emerging as the most cost-effective option. Overall, modest shares of tyre pyrolysis oil (10 %) and long-chain alcohols (≤5 %) in waste-oil biodiesel can provide an attractive compromise between energy effi ciency, emissions and exergy-based cost, supporting circular-economy-oriented diesel combustion.
Arcuate foramen of the atlas vertebra and its correlation with clinical implications in the craniocervical region: A systematic review and meta-analysis
(Elsevier, 2025) Valenzuela-Fuenzalida, Juan José; Cornejo-Peña, Javiera; Martinez-Cid, Josefina; Rojas-Acuña, Cristobal; Granite, Guinevere; Sanchis-Gimeno, Juan A.; Bruna Mejias, Alejandro; Nova Baeza, Pablo; Orellana Donoso, Mathias; Oyanedel Amaro, Gustavo; Becerra- Farfan, Álvaro; Rodriguez-Luengo, Macarena; Nteli Chatzioglou, Gkionoul; Konchaske, Marko
Background context The arcuate foramen (FA) can present in various forms: it may be complete, incomplete, unilateral, or bilateral. This anatomical feature is relatively common, occurring in approximately 3-15% of the population, with a higher prevalence in females. Purpose The purpose of this study is to provide rigorous scientific evidence detailing the anatomical characteristics of the AF. Furthermore, this work aims to analyze the prevalence and explore its relevance in clinical applications and surgical procedures. Study desing Systematic review and meta-analysis Methods Data were compiled from numerous published studies accessed from the databases Medline, Scopus, Web of Science, EMBASE, Google Scholar, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and of April 2025. Methodological quality was evaluated with an assurance tool for anatomical studies (AQUA). Pooled prevalence was estimated using a random effects model, and differences in FA variant rates were assessed. Results FA variants were identified, the data were categorized into three groups: the first category was the type of sample, divided into cadaver donor samples and imaging findings; the second analysis focused on the geographical region from which the sample originated; and finally, sex and laterality were also considered. Overall, the prevalence of these variations was 16% (CI: 11%–20%), and significant heterogeneity (98.8%) was observed. Significantly higher rates were observed in the following subgroups: imaging studies versus donor data (p=0.032), right side versus left side (p=0.034), and bilateral versus unilateral findings (p=0.019). Among the concerns raised were studies on the risk of iatrogenic damage during surgical procedures. Several studies also indicated a higher frequency of vertebral artery variations in patients with symptoms such as recurrent headaches, vertigo, dizziness, and/or syncope. Conclusion This review emphasized the importance of considering the vertebral artery (VA) in the preoperative assessment of surgical procedures involving the placement of screws in the cervical spine, such as treatment for atlantoaxial instability. Lack of knowledge regarding the anatomy of this region can lead to complications, such as vertebral artery injury and, consequently, impaired blood flow to the brain, cerebellum, and brainstem. Therefore, the authors recommend further research on this topic, particularly in other patient populations and in collaboration with other disciplines, to advance our understanding of the vertebral artery and to provide valuable tools for healthcare professionals and researchers, thus contributing to improved patient care.
