İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
In vitro evaluation of methyl methacrylate (MMA) release from different temporary denture base materials
(Dennis Barber Journals, 2025) Dilaverler Yardım, Esra Ayşe; Özer, Safa; Atasoyu Akgün, Begüm; Çakan, Umut
INTRODUCTION: Residual methyl methacrylate (MMA) released from temporary denture base materials is of clinical concern due to its potential biological effects. Recently, light polymerized and 3D-printed denture base resins have emerged as alternatives to conventional cold-polymerized acrylics. This study aimed to compare the in vitro MMA release levels of three clinically relevant temporary denture base materials. MATERIALS AND METHODS: Three materials were tested: cold-polymerized acrylic resin, light-polymerized baseplate resin, and 3D-printed denture base resin. Ten samples were prepared for each group (n=10), standardized to 0.05 g per specimen. Samples were immersed in 2 mL and 5 mL of artificial saliva and incubated at 37°C. MMA release was quantified using high-performance liquid chromatography (HPLC) at 15 minutes, 30 minutes, 1 hour, and 24 hours. Data distribution was analyzed with the Shapiro-Wilk test; the effects of time, material, and saliva volume were assessed using two-way ANOVA and Tukey post-hoc tests (p<0.05). RESULTS: No MMA release was detected before 24 hours in the 3D-printed and light-polymerized groups. The cold polymerized acrylic group showed progressive MMA release starting from 15 minutes, with a significant increase over time (p<0.001). At 24 hours, it exhibited the highest MMA levels among all groups. A significant difference between 2 mL and 5 mL saliva volumes was observed only in the cold-cure group. The 3D-printed resin showed the most stable performance across all time points. CONCLUSION: Temporary denture base materials should be selected with consideration of residual monomer release. The results support the biocompatibility of 3D-printed resins for short-term clinical applications, especially when early MMA release and toxicity are of concern.
The effect of commonly used polishing protocols on the color stability of 3D- printed temporary crowns
(Dennis Barber Journals, 2025) Yazar Özdemir, Nedime Zeynep; Dilaverler Yardım, Esra Ayşe
OBJECTIVE: Color stability is a crucial parameter for maintaining the long-term esthetic success of temporary restorations. This study aimed to evaluate the effects of different clinical polishing protocols applied to three-dimensional (3D) printed temporary resin crowns on their color stability. MATERIALS-METHODS: Fifty standardized specimens (12×12×2 mm) were prepared using a 3D printing resin material (PowerResins, Temp Resin, A2, Turkiye) and randomly divided into five groups (n=10) as G1: Control (no polishing), G2: Mechanical polishing (DCPT 14 RA SET), G3: Silicon dioxide containing polishing paste (Promida Prophy P), G4: Mechanical + silicon dioxide paste, G5: Diamond particle-containing polishing paste (Intensiv Unigloss). Initial color measurements were performed using a digital spectrophotometer (Vita Easyshade V). TSpecimens were exposed to a daily coffee cycle for 15 days. Color differences were calculated using the CIEDE2000 (ΔE00) formula, and the data were analyzed by one way analysis of variance (ANOVA). Tukey’s post-hoc test was applied for multiple comparisons (p < 0.05). RESULTS: No significant differences were observed between the groups before the coffee staining cycle (p > 0.05). After staining, intergroup differences were statistically significant (p < 0.05). The lowest ΔE00 values were recorded in G5 (diamond particle- containing polish). G3 and G4 exhibited moderate color changes, comparable to the control group (G1). The highest color change was observed in G2 (mechanical polishing only), with ΔE00 values exceeding the clinically perceptible threshold (ΔE00 ≥ 0.8). CONCLUSION: The diamond particle-containing polishing paste provided the best color stability both statistically and clinically. The polishing protocol plays a decisive role in the color stability of 3D-printed temporary crowns. The use of diamond-containing polishing systems is recommended, particularly in esthetic zone restorations.
What is new in the 2025 APASL guidelines for metabolic dysfunction-associated fatty liver disease?
(AME Publishing Company, 2026) Pan, Ziyan; Örmeci, Necati; Chen, Jinjun; Ghazinian, Hasmik; Payawal, Diana; Eslam, Mohammed
As the global epidemics of obesity and type 2 diabetes mellitus (T2DM) continue to rise, metabolic dysfunction associated fatty liver disease (MAFLD) has become the most common chronic liver disease globally. The Asia-Pacific region is particularly affected, accounting for a significant majority of global liver-related deaths (1). To address this, the Asian Pacific Association for the Study of the Liver (APASL) has released updated clinical practice guidelines in 2025 (2). This article is a commentary focusing on the key changes and new recommendations within those guidelines, which were published in Hepatology International (2). Recognizing the limitations of the exclusionary diagnostic criteria for non-alcoholic fatty liver disease (NAFLD) and emphasizing the key role of metabolic dysfunction in disease pathogenesis, the introduction of the MAFLD definition in 2020 was a milestone in disease research and clinical practice (3-5). This shift reflects a significant evolution in our understanding of the disease, moving away from a diagnosis of exclusion towards one of inclusion based on metabolic dysfunction, recognizing the central role of metabolic factors and introducing the key concept of dual etiology, including alcohol consumption or coexisting liver diseases (6). Over the past 5 years, there have been significant advancements in understanding the disease, culminating in new knowledge, the first approved treatment, and the beginning of a new era of artificial intelligence (AI) with potential promise for hepatology. These changes stimulate the need for an updated document of the APASL guidelines for the diagnosis and management of MAFLD, which was recently released in 2025 (2). This updated guideline provides a comprehensive framework for addressing the growing burden of MAFLD in the Asia-Pacific region. This commentary aims to highlight the key aspects in this landmark document and touch on the main changes from the 2020 version (7).
Kardiyopulmoner resüsitasyon ve acil durumlarda sık kullanılan ilaçlar
(Ankara Nobel Tıp Kitabevleri, 2025) Askeroğlu, Araz; Güler, Hicran; Askeroğlu, Araz; Yavuz van Giersberge, Meryem
Yoğun bakımlarda yatan hastalarda hemodinamiğin stabil bir şekilde sürdürülmesi hedeflenir. Kardiyovasküler hastalıklar, hipovolemi, elektrolik dengesizlikleri, hipoksi, asidoz vb nedenlerden dolayı hemodinamik dengesizlik ve tedavi edilmediği takdirde kardiyaksolunum arrest meydana gelebilir. Kardiyak- solunum arreste ilişkin solunum ve dolaşımı sağlama ve hemodinamik dengeyi korumaya yönelik tıbbi araç gereçler birlikte bazı ilaçların kullanılması da gereklidir. Bu bölümde yoğun bakımda acil vakaların yönetiminde sıklıkla kullanılan ilaçlar, ilaç grupları, kullanım şekilleri, farmakokinetik-famakodinamik, etki mekanizması, endikasyonlar, kontrendikasyonlar, yan etkiler ve ilaçlara ilişkin hasta yönetiminde dikkat edilmesi gereken hususlar verilmiştir.
Waste toner particles based dispersive solid phase extraction for the trace determination of cadmium in cinnamon tea samples by flame atomic absorption spectrometry
(Elsevier, 2026) Ali, Büşra; Büyük, Muhammed Ali; Bayraktar, Ahsen; Serbest, Hakan; Bakırdere, Sezgin
This study presents a dispersive solid phase extraction (DSPE) protocol for the sensitive and accurate determi nation of trace levels of cadmium ions (Cd2+) by flame atomic absorption spectrometry (FAAS). Toner particles obtained from used printer cartridges were used as sorbent material for preconcentration of Cd2+ ions. Opti mization studies were performed univariately for the achievement of the highest extraction efficiency and the limit of detection (LOD) was found to be 0.55 µg L-1 under optimal operating conditions. By comparing the slopes of the linear plot equations for FAAS and waste toner-based DSPE-FAAS systems, the increase in sensitivity was calculated to be 40.9 times. The feasibility of the developed method was evaluated by spiking recovery studies on cinnamon tea samples and good recovery results between 90.4 % and 119.0 % determined by the matrix matching calibration strategy showed that the method is applicable to cinnamon tea and similar matrices.
