İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
DSpace@İSTÜN, Üniversite mensupları tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Evaluation of the prevalence and location of second mesiobuccal canals in 2100 upper first and second molar teeth: A cone beam computed tomography study
(Inonu University, 2025) Kaplan, Bahar; Adıgüzel, Özkan; Öner Talmaç, Ayşe Gül; Aslan Öztürk, Elif Meltem
It is essential to undertake thorough preparation, debridement and filling of all root canals in order to achieve a clinically successful treatment outcome. A total of 525 CBCT images of both maxillary first and second molars were analyzed. The observations and measurements were positioned 1 millimeter (mm) apically from the pulp base to standardize the methodology for the detection of the second mesiobuccal canal (MB2). To assess the distances between the canals and the relationship between the presence of MB2 and mesiobuccal (MB) root length, MB root length was quantified in millimeters. IBM SPSS Version 21.0 was employed for statistical analyses, with a type I error level of 5% accepted. MB2 was identified in 36.5% of the first maxillary molar (1MM) and second maxillary molar (2MM) teeth of the patients included in the study. When the frequency of MB2 was evaluated according to gender and right-left side, no statistically significant difference was found (p>0.05). When examining the relationship between the presence of MB2 and the length of the MB root, it was observed that only in the left second molars with MB2 present, the root length was slightly shorter. It is our contention that this study will furnish dentists with crucial data that will enhance the efficacy of root canal therapy for these teeth.
Challenges and strategies in effective nursing leadership: Viewpoints of nurses in management positions – A qualitative study
(Emerald Publishing, 2025) Aydoğdu, Ana Luiza Ferreira
Purpose – To explore the viewpoints of nurses in management positions on the challenges they face and the strategies they use to promote effective leadership in the nursing workplace. Design/methodology/approach – This qualitative study involved 42 Brazilian nurses in management positions, working in various settings across Brazil, who responded to open-ended online questions between January 1, 2025 and February 15, 2025. Findings – Five themes were identified: (1) highlighted leadership styles, (2) difficulties of leading the nursing team, (3)strategies used to solve problemsin the leadership process, (4) learning to lead and (5) making nursing leadership more effective. Research limitations/implications – The study presents important perspectives from nurses in managerial positions on the key role that effective leadership plays in fostering healthy work environments in nursing. Nevertheless, it hassome limitations, including the use ofself-report questionnaires, regional imbalance among participants, potential bias due to data analysis being conducted by a single researcher and the absence of an assessment based on the leader–member exchange framework. Practical implications – Nurses in management positions recognize the importance of empowering team members. Nurse managersshould receive proper education to competently assume theirleadership responsibilities. Originality/value – The study highlights the need to revise nursing curricula to incorporate early and continuous leadership education, supported by ongoing in-service programs. It also emphasizes the importance of fostering team cohesion through open communication, mutual respect and shared goals. Additionally, it is pointed out that upper managementshould empower nurse leaders at all levels and provide regular, constructive feedback to support effective leadership.
Investigation of the effects of fluoride varnish, silver diamine fluoride and peptide P11-4 on dentin nanostructure in an in-vitro dentin caries model via SEM, FTIR spectroscopy and SAXS methods
(MRE Press, 2025) Yoğurucu Değerli, Gizem; Güven Polat, Günseli; İde, Semra; Bülbül, Onurcan
Background: To evaluate and compare the structural effects of fluoride varnish, silver diamine fluoride (SDF), and peptide P11-4 on dentin nanostructure in an in vitro dentin caries model. Methods: Forty dentin discs were demineralized and treated with either SDF, fluoride varnish or P11-4. Structural changes were assessed using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and small angle X-ray scattering (SAXS) to evaluate topographical, molecular and nanoscale modifications. Results: SEM revealed morphological differences across groups: the P11-4 group showed fibrillar structures and narrowed dentinal tubules; the SDF group exhibited blocked tubules with a granular appearance; and the fluoride varnish group presented partially occluded tubules. FTIR analysis showed a reduction in Amide A and Amide I bands in the P11-4 group, suggesting enhanced interaction with dentin collagen and early-stage remineralization. In contrast, the SDF group showed higher Amide A values, indicating limited interaction with the organic matrix. These spectral shifts imply differential impacts on the preservation and reorganization of the dentin matrix. SAXS analysis confirmed that the P11-4 group exhibited the closest nanostructural resemblance to healthy dentin, whereas the SDF group showed the least similarity. Both the P11-4 and fluoride varnish groups demonstrated organized fibrillar alignment and improved mineral patterning. Conclusions: The findings suggest that P11-4, through its biomimetic action, facilitates favorable nanostructural and molecular changes in demineralized dentin. These effects may contribute to enhanced mechanical stability and long-term clinical outcomes. Broader in vivo studies are warranted to validate these results before clinical application.
Can neoadjuvant chemoradiotherapy be omitted in cT2N+ and cT3 mid-rectal cancer: Protocol for a prospective, observational, cohort study (CANO)
(Public Library of Science, 2025) Karakayalı, Feza; Arslan, Çiğdem; Bisgin, Tayfun; Erenler Bayraktar, İlknur; Bayraktar, Onur; Canda, Aras Emre
Background Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision (TME) is the standard treatment for locally advanced rectal cancer. However, nCRT is associ ated with significant morbidity, impacting patients’ quality of life. Recent advancements in MRI-based risk stratification have raised the possibility of omitting nCRT in selected patients without compromising oncologic outcomes. This study aims to evaluate whether upfront TME alone achieves similar 3-year disease-free survival compared to the standard approach of nCRT followed by TME in patients with cT2N+ and cT3Nx mid-rectal cancer without MRI-based high-risk features regarding local recurrence. Methods The CANO trial is a prospective, multicenter, observational cohort study involving 436 patients across Türkiye. Eligible patients will be classified into two groups: those undergoing direct TME and those receiving nCRT followed by TME. The primary endpoint is 3-year disease-free survival (DFS), with secondary outcomes including 5-year DFS, overall survival, local recurrence rates, and quality of life assessments using validated questionnaires. Data will be prospectively collected and monitored by the steering committee with predefined interim analyses. Discussion The CANO trial addresses the ongoing debate regarding selective omission of nCRT in low-risk mid-rectal cancer. By leveraging MRI-based risk stratification and PLOS One | https://doi.org/10.1371/journal.pone.0321819 November 5, 2025 2 / 11 a collaborative national network, the study aims to provide high-quality evidence supporting a more personalized treatment approach. The findings have the potential to reduce treatment-related morbidity without compromising oncologic safety, contrib uting to the refinement of current guidelines.
LC-MS/MS methods for the determinatıon of paclitaxel in biological fluıds: A review
(Gece Kitaplığı, 2025) Şenol, Mahmut Raşit; Sağlık Aslan, Serap
Oncology stands out as a dynamic field of science, driven by contin uous development and innovative research leading to advances in treat ment methods. In this context, paclitaxel is a chemotherapy drug that is effectively used in the treatment of a wide variety of cancer types. The drug’s areas of application include breast, ovarian, bladder, lung, prostate, melanoma, oesophageal cancers, Kaposi’s sarcoma, and various other solid tumours. This review details paclitaxel’s therapeutic indications, its mechanism of action at the cellular level, its role in suppressing tumour cell proliferation, as well as dosage adjustments, infusion protocols, routes of administration, and possible contraindications; it also emphasises the clinical importance of monitoring patients undergoing treatment. Pacli taxel, initially known as “taxol” when it was first discovered, is a natural diterpenoid compound derived from the Pacific yew tree (Taxus brevifo lia). The drug’s discovery was the result of natural product screening pro grammes conducted by the National Cancer Institute (NCI) in the United States in the late 1960s and early 1970s. During this process, research ers examined various plant extracts in an effort to identify compounds with anticancer potential, and paclitaxel’s pronounced cytotoxic effects attracted attention. In particular, its capacity to halt the cell cycle and induce apoptosis by inhibiting microtubule depolymerisation has made paclitaxel a priority agent in anticancer research (1).
