Could ofloxacin be an alternative to amoxicillin–metronidazole as an adjunct to non-surgical periodontal therapy?
| dc.authorid | 0000-0001-6659-8306 | en_US |
| dc.authorscopusid | 57209970143 | en_US |
| dc.authorwosid | AAA-2574-2022 | en_US |
| dc.contributor.author | Alkan, Begüm | |
| dc.contributor.author | Altaş, Nurcan | |
| dc.date.accessioned | 2023-10-18T11:50:32Z | |
| dc.date.available | 2023-10-18T11:50:32Z | |
| dc.date.issued | 2023 | en_US |
| dc.department | Fakülteler, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü, Periodontoloji Ana Bilim Dalı | en_US |
| dc.description.abstract | Objective: The best antibiotic approach for generalized periodontitis remains under debate. Therefore, in this study, the systemic administration of ofloxacin was compared against amoxi cillin–metronidazole in terms of clinical periodontal parameters. Materials and Methods: A prospective, experimental, double-blind, active-controlled, randomized, parallel-grouped, and single-centered clinical trial was carried out at a university hospital in Istanbul, Turkey, between April 2017 and August 2019. Seventy-four patients with generalized periodontitis were randomized into 2 study groups (ofloxacin and amoxicillin–metronidazole groups). Clinical periodontal parameters were recorded at baseline and at 1-, 3-, and 6-month follow-ups following phase 1 periodontal therapy. Changes in clinical periodontal parameters from baseline to 6 months were evaluated and compared between groups. Results: Thirty-eight patients were lost to follow-up and excluded from the analysis. Thirty-six patients completed the study (ofloxacin group, n=18; amoxicillin–metronidazole group, n=18). The clinical periodontal parameters were significantly reduced in both groups at all time points compared to baseline (P < .05). No significant differences in plaque or gingival indices were observed between the groups at any time point (P > .05). Bleeding on probing at 1 month as well as probing depth and clinical attachment loss at 6 months were significantly lower in the amoxicillin–met ronidazole group compared to the ofloxacin group (P < .05). No adverse effects were reported. Conclusion: Systemic ofloxacin administration as an adjunct to non-surgical periodontal therapy showed significant clinical improvement during the first 3 months but was not as effective as amoxicillin–metronidazole at 6 months. | en_US |
| dc.description.abstract | Amaç: Generalize periodontitis için en iyi antibiyotik yaklaşımının hangisi olduğu tartışma konusudur. Bu nedenle, bu çalışmada, klinik periodontal parametreler açısından, ofloksasinin sistemik uygulaması amoksisilin-metronidazolünkiyle karşılaştırıldı. Metodlar: Prospektif, deneysel, çift körlü, aktif kontrollü, randomize, paralel gruplu ve tek merkezli klinik çalışma, Nisan 2017 ile Ağustos 2019 tarihleri arasında İstanbul, Türkiye'deki bir üniversite hastanesinde gerçekleştirildi. Generalize periodontitisli 74 hasta, iki çalışma grubuna (ofloksasin ve amoksisilin-metronidazol grupları) randomize edildi. Klinik periodontal parametreler başlangıçta ve faz 1 periodontal tedaviyi takiben birinvi, üçüncü ve altıncı ay takiplerinde kaydedildi. Klinik periodontal parametrelerdeki değişiklikler, başlangıçtan altıncı aya kadar değerlendirildi ve gruplar arasında karşılaştırıldı. Bulgular: Otuz sekiz hasta takip edilemedi ve analizden çıkarıldı. Otuz altı hasta çalışmayı tamamladı (ofloksasin grubu, n=18; amoksisilin-metronidazol grubu, n=18). Klinik periodontal parametreler, başlangıca kıyasla tüm zaman noktalarında her iki grupta da önemli ölçüde azaldı (p < 0.05). Geliş Tarihi/Received: 21.02.2023 Kabul Tarihi/Accepted: 12.05.2023 Yayın Tarihi/Publication Date: 31.07.2023 Sorumlu Yazar/Corresponding Author: Begüm ALKAN E-mail: alkan.bgm@gmail.com Cite this article as: Alkan B, Altaş N. Could ofloxacin be an alternative to amoxicillin–metronidazole as an adjunct to non-surgical periodontal therapy? Curr Res Dent Sci. 2023;33(3):153-159. Begüm ALKAN1 Nurcan ALTAŞ2 1 Department of Periodontology, Faculty of Dentistry, İstanbul Health and Technology University, İstanbul, Turkey (previously Department of Periodontology, Faculty of Dentistry, İstanbul Medipol University, İstanbul, Turkey) 2 Department of Periodontology, Faculty of Dentistry, İstanbul Medipol University, İstanbul, Turkey doi: 10.5152/CRDS.2023.23173 Content of this journal is licensed under a Creative Commons AttributionNonCommercial-NoDerivatives 4.0 International License. 154 Curr Res Dent Sci 2023 33(3): 153-159 l doi: 10.5152/CRDS.2023.23173 Herhangi bir zaman noktasında, gruplar arasında, plak veya gingival indeksinde anlamlı fark gözlenmedi (p > 0.05). Ofloksasin grubuyla karşılaştırıldığında amoksisilin-metronidazol grubunda birinci ayda sondalamada kanama, altıncı ayda sondalama derinliği ve klinik ataşman kaybı anlamlı olarak daha düşüktü (p < 0.05). Herhangi bir yan etki bildirilmemiştir. Sonuç: Cerrahi olmayan periodontal tedaviye ek olarak kullanılan sistemik ofloksasin uygulaması, ilk üç ayda önemli klinik iyileşme gösterirken, altıncı ayda amoksisilin-metronidazol kadar etkili değildi. | en_US |
| dc.identifier.citation | Alkan, B., & Altaş, N. (2023). Could ofloxacin be an alternative to amoxicillin–metronidazole as an adjunct to non-surgical periodontal therapy? Current Research in Dental Sciences, 33(3), pp. 153-159. https://doi.org/10.5152/CRDS.2023.23173 | en_US |
| dc.identifier.doi | 10.5152/CRDS.2023.23173 | en_US |
| dc.identifier.endpage | 159 | en_US |
| dc.identifier.issn | 1300-9044 | |
| dc.identifier.issn | 2667-5161 | |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.scopus | 2-s2.0-85173102544 | en_US |
| dc.identifier.startpage | 153 | en_US |
| dc.identifier.trdizinid | 1272786 | |
| dc.identifier.uri | https://doi.org/10.5152/CRDS.2023.23173 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.13055/564 | |
| dc.identifier.volume | 33 | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.institutionauthor | Alkan, Begüm | |
| dc.language.iso | en | en_US |
| dc.publisher | Ataturk University Publications | en_US |
| dc.relation.ispartof | Current Research in Dental Sciences | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Amoxicillin | en_US |
| dc.subject | Metronidazole | en_US |
| dc.subject | Ofloxacin | en_US |
| dc.subject | Periodontitis | en_US |
| dc.subject | Root Planning | en_US |
| dc.subject | Amoksisilin | en_US |
| dc.subject | Kök Yüzeyi Düzleştirme | en_US |
| dc.subject | Metronidazol | en_US |
| dc.subject | Ofloksasin | en_US |
| dc.subject | Periodontitis | en_US |
| dc.title | Could ofloxacin be an alternative to amoxicillin–metronidazole as an adjunct to non-surgical periodontal therapy? | en_US |
| dc.title.alternative | Ofloksasin, cerrahi olmayan periodontal tedaviyle beraber kullanılan amoksisilin metronidazolün alternatifi olabilir mi? | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication |
