Coordination-driven assembly of alginate networks: From egg-box structures to bioactive delivery applications

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dc.authorid0000-0001-9870-8514
dc.authorid0000-0002-2241-2562
dc.authorid0000-0003-2351-172X
dc.authorid0000-0002-9989-9823
dc.contributor.authorToprakçı, İrem
dc.contributor.authorKurtulbaş, Ebru
dc.contributor.authorBozkurt, Rabia Nur
dc.contributor.authorŞahin, Selin
dc.date.accessioned2026-09-03T06:46:27Z
dc.date.available2026-09-03T06:46:27Z
dc.date.issued2026
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Mühendisliği Bölümü
dc.description.abstractAlginate is a biodegradable and renewable natural polysaccharide that has been extensively investigated for the design of macromolecular delivery systems. This review presents an overview of alginate-based microparticles regarding the relationship between molecular structure, gelation behavior, and functional performance. The impacts of main structural parameters (mannuronic to guluronic acid (M/G) ratio, molecular weight, and block distribution) are discussed comprehensively. Particular attention is given to Ca2+-mediated ionic gelation, including egg-box junction zone formation and the development of three dimensional hydrogel networks. Different production strategies such as external and internal gelation, emulsification, and microfluidic approaches are evaluated in terms of their impact on particle morphology and network homogeneity. In addition, the effects of formulation and process parameters on encapsulation efficiency, mechanical stability, and mass transfer behavior are analyzed. Furthermore, release mechanisms are discussed in relation to network structure and polymer-solute interactions. The environmental significance of alginate-based systems is also emphasized as sustainable alternatives to synthetic polymeric carriers.
dc.identifier.citationToprakçı, İ., Kurtulbaş, E., Bozkurt, R. N., & Şahin, S. (2026). Coordination-driven assembly of alginate networks: From egg-box structures to bioactive delivery applications. Gels, 12(9), pp. 1-41. https://doi.org/10.3390/gels12090774
dc.identifier.doi10.3390/gels12090774
dc.identifier.endpage41
dc.identifier.issn2310-2861
dc.identifier.issue9
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.3390/gels12090774
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1622
dc.identifier.volume12
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorBozkurt, Rabia Nur
dc.institutionauthorid0000-0003-2351-172X
dc.language.isoen
dc.publisherMDPI Publishing
dc.relation.ispartofGels
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlginate
dc.subjectCa2+-Mediated Crosslinking
dc.subjectEgg-Box Model
dc.subjectMicroparticles
dc.subjectBioactive Delivery
dc.titleCoordination-driven assembly of alginate networks: From egg-box structures to bioactive delivery applications
dc.typeReview Article
dspace.entity.typePublication

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