Polyherbal ointment with bromelain for chronic diabetic wounds: Insights from a clinical case series

Basit Öğe Kaydı
dc.authorid0000-0003-0159-1263
dc.authorid0000-0001-6212-2706
dc.authorid0000-0001-6659-9333
dc.authorid0000-0003-1470-356X
dc.authorid0000-0003-2774-8601
dc.contributor.authorBostanabad, Saber Yari
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorSaadati, Mahrokh
dc.contributor.authorKaraca, Banu
dc.contributor.authorŞener, Alper
dc.date.accessioned2025-11-05T07:20:40Z
dc.date.available2025-11-05T07:20:40Z
dc.date.issued2025
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalı
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractPurpose Chronic diabetic wounds are characterized by prolonged inflammation and impaired healing. This study evaluates a novel polyherbal ointment, W Cura D Plus®, which contains Azadirachta indica oil, Hypericum perforatum oil, and bro melain from Ananas comosus. After initial debridement with W Cura D Plus®, treatment continued with W Cura G Plus®. To our knowledge, this is the first clinical report examining this specific combination in the treatment of chronic diabetic wounds. Methods A single-center clinical case series was conducted in 13 diabetic patients with Wagner grade 2–3 diabetic foot ulcers of at least 4 weeks’ duration. All patients were on standard type 2 diabetes therapy (oral agents and/or insulin) and routine wound care prior to enrollment. W Cura D Plus® was applied daily for 7 days to promote debridement, followed by W Cura G Plus® until complete closure or no further reduction in ulcer size for two consecutive weeks. Clinical endpoints included wound area, closure percentage, and recovery time. White blood cell (WBC) and C-reactive protein (CRP) levels were monitored. Results Fourteen wound observations were analyzed. Mean wound area decreased from 25.07±24.56 cm² at baseline to 7.38±5.15 cm² (p=0.0103), and mean closure rate was 64.15±0.23% (p=0.0108), surpassing the 50% benchmark for clini cally meaningful improvement. Recovery time averaged 97.7 days compared to baseline (initial status prior to treatment). WBC and CRP significantly declined (p<0.0001). No adverse events were reported. Conclusion This polyherbal formulation may represent a safe adjunct to standard care, but larger controlled trials are needed to confirm efficacy.
dc.identifier.citationBostanabad, S. Y., Özdemir, S., Saadati, M., Karaca, B., & Şener, A. (2025). Polyherbal ointment with bromelain for chronic diabetic wounds: Insights from a clinical case series. Journal of Pharmaceutical Innovation, 20(1), pp. 1-11. https://doi.org/10.1007/s12247-025-10195-1
dc.identifier.doi10.1007/s12247-025-10195-1
dc.identifier.endpage11
dc.identifier.issn1939-8042
dc.identifier.issn1872-5120
dc.identifier.issue1
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1007/s12247-025-10195-1
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1161
dc.identifier.volume20
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorBostanabad, Saber Yari
dc.institutionauthorÖzdemir, Samet
dc.institutionauthorid0000-0003-0159-1263
dc.institutionauthorid0000-0001-6212-2706
dc.language.isoen
dc.publisherSpringer Nature Link
dc.relation.ispartofJournal of Pharmaceutical Innovation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiabetic Wound Healing
dc.subjectBromelain
dc.subjectPolyherbal Formulation
dc.subjectTopical Phytotherapy
dc.subjectEnzymatic Debridement
dc.titlePolyherbal ointment with bromelain for chronic diabetic wounds: Insights from a clinical case series
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
Tam Metin / Full Text
Boyut:
1.32 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Farmakoloji Ana Bilim Dalı Koleksiyonu
Farmasötik Teknoloji Ana Bilim Dalı Koleksiyonu