A novel HPLC method for selexipag in human plasma and application to a prototype pharmacokinetic study

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dc.authorid0000-0002-1871-017Xen_US
dc.authorid0000-0002-5840-7386en_US
dc.authorscopusid49964600400en_US
dc.authorscopusid6701367993en_US
dc.authorwosidA-3672-2016en_US
dc.authorwosidFZV-5400-2022en_US
dc.contributor.authorCeylan, Burhan
dc.contributor.authorTırıs, Gizem
dc.contributor.authorKepekçi Tekkeli, Şerife Evrim
dc.contributor.authorÖnal, Cem
dc.contributor.authorÖnal, Armağan
dc.date.accessioned2023-12-02T11:44:58Z
dc.date.available2023-12-02T11:44:58Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalıen_US
dc.description.abstractA novel simple and cost effective HPLC technique was presented for the quantification of selexipag (SLP) in human plasma sample and the technique’s applicability to a pharmacokinetic investigation. Chromatographic separation was achieved with C18 (5 μm 3 4.6 mm 3 150 mm) column, at 30 8C with isocratic elution, mobile phase composed of solution A (acetonitrile), and solution B (0.5% formic acid) (65:35 v/v) at flow rate 1.2 mL min 1 . The linearity range is 10–150 ng mL 1 . As sample preparation step human plasma was precipitated with acetonitrile and the detection was provided at 300 nm. The retention time is 8.20 ± 0.02 min. LOD is found to be 3.3 ng mL 1 for drug. The method was applied to the analysis of SLP in human plasma with good recovery as 97.83%. Validation of the studied methods was carried out according to EMA guideline. The new method applied on a prototype pharmacokinetic study by administration of 800 μg SLP to a healthy volunteer and parameters like AUC0–24, AUC0–∞, Cmax, tmax, and t1/2 were assessed.en_US
dc.identifier.citationCeylan, B., Tırıs, G., Kepekçi Tekkeli, Ş. E., Önal, C., & Önal, A. (2023). A novel HPLC method for selexipag in human plasma and application to a prototype pharmacokinetic study. Acta Chromatographica, 36(3), pp. 273-278. https://doi.org/10.1556/1326.2023.01167en_US
dc.identifier.doi10.1556/1326.2023.01167en_US
dc.identifier.endpage278en_US
dc.identifier.issn1233-2356
dc.identifier.issn2083-5736
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85179043351en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage273en_US
dc.identifier.urihttps://doi.org/10.1556/1326.2023.01167
dc.identifier.urihttps://hdl.handle.net/20.500.13055/591
dc.identifier.volume36en_US
dc.identifier.wosWOS:001308771100011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorKepekçi Tekkeli, Şerife Evrim
dc.institutionauthorÖnal, Cem
dc.language.isoenen_US
dc.publisherAkademiai Kiadoen_US
dc.relation.ispartofActa Chromatographicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSelexipagen_US
dc.subjectHPLC-UVen_US
dc.subjectPharmacokineticsen_US
dc.subjectHuman Plasmaen_US
dc.subjectPulmonary Arterial Hypertensionen_US
dc.titleA novel HPLC method for selexipag in human plasma and application to a prototype pharmacokinetic studyen_US
dc.typeArticleen_US
dspace.entity.typePublication

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