Comparison of neuropsychological side effects between contemporary radiofrequency ablative neurosurgery for psychiatric disorders and conventional neurosurgical procedures: Systematic review and meta-analysis

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dc.authorid0000-0002-1360-1580
dc.authorid0000-0001-8047-7164
dc.authorid0009-0007-8952-9662
dc.authorid0000-0002-7586-2487
dc.authorid0000-0003-0439-8215
dc.authorid0000-0001-5930-6037
dc.authorid0000-0003-1802-8223
dc.authorid0000-0002-1081-3545
dc.contributor.authorVilela Filho, Osvaldo
dc.contributor.authorBannach, Matheus A.
dc.contributor.authorMartins Lino Filho, Adriano
dc.contributor.authorHamani, Clement
dc.contributor.authorNuttin, Bart
dc.contributor.authorHariz, Marwan
dc.contributor.authorSchulder, Michael
dc.contributor.authorDavid Greenberg, Benjamin
dc.contributor.authorYılmaz, Atilla
dc.contributor.authorGonçalves Ferreira, António
dc.date.accessioned2026-04-19T13:31:50Z
dc.date.available2026-04-19T13:31:50Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractBackground Psychiatric disorders are increasingly contributing to global disability. Despite advances in conservative management, the prevalence of treatment-resistant cases remains high. Meanwhile, neurosurgery for psychiatric disorders (NPD) remains underused, largely due to strict regulations and historical concerns, particularly those related to neuropsychological side effects (NPSE). Objective To address this issue, we conducted a systematic review with meta-analysis to compare NPSE associated with radiofrequency ablative NPD to those observed in neuro-oncological, neurovascular and epilepsy surgeries. Methods PubMed, Embase and LILACS databases were searched in April 2024 for articles published in English/Spanish from 1990 to 2022, following Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Results A total of 48 articles with 2678 participants were included. The frequency of transient and permanent NPSE in the NPD group ranged from 0.94% to 11.50% and 0.94% to 2.03%, respectively, comparable to the other surgical groups (epilepsy: 0.31–11.70%; vascular: 0.52–22.90%; oncology: 0.94–17.60% for transient NPSE; epilepsy: 0.31–12%; vascular: 0.40–1.96% and oncology: 0.84–1.48% for permanent NPSE). Regarding permanent NPSE, arguably the most critical consideration, the NPD group showed better outcomes in memory, language and social cognition than the epilepsy group, but worse outcomes in executive and perceptual-motor functions. Compared with the vascular group, the NPD group had better executive function but worse complex attention. Finally, the NPD group had fewer permanent deficits than the oncology group in executive function, complex attention and perceptual-motor domains, although language performance was lower. Conclusions Contemporary NPD apparently carries a similar risk of NPSE as other conventional neurosurgical procedures, challenging misconceptions and this unjustified barrier to its broader use.
dc.description.sponsorshipOpen access publication of this article was supported by funding associated with SAS through NIH/NINDS (UH3 NS103549). The authors would like to thank Normando G. Pereira Neto for his help in data extraction (oncological surgery) at the beginning of this study. Bu makalenin açık erişimli yayınlanması, NIH/NINDS (UH3 NS103549) aracılığıyla SAS ile ilişkili fonlama ile desteklenmiştir. Yazarlar, bu çalışmanın başlangıcında veri çıkarma (onkolojik cerrahi) konusunda yardımlarından dolayı Normando G. Pereira Neto'ya teşekkür etmek isterler.
dc.identifier.citationVilela Filho, O., Bannach, M. A., Martins Lino Filho, A., Hamani, C., Nuttin, B., Hariz, M., Schulder, M., David Greenberg, B., Yılmaz, A., & Gonçalves Ferreira, A. (2026). Comparison of neuropsychological side effects between contemporary radiofrequency ablative neurosurgery for psychiatric disorders and conventional neurosurgical procedures: Systematic review and meta-analysis. Journal of Neurology, Neurosurgery and Psychiatry, pp. 1-10. https://doi.org/10.1136/jnnp-2025-337800
dc.identifier.doi10.1136/jnnp-2025-337800
dc.identifier.endpage10
dc.identifier.issn1468-330X
dc.identifier.issn0022-3050
dc.identifier.pmidPMID: 41946555
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1136/jnnp-2025-337800
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1430
dc.identifier.wosWOS:001735921600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorYılmaz, Atilla
dc.institutionauthorid0000-0002-1081-3545
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.relation.ispartofJournal of Neurology, Neurosurgery and Psychiatry
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleComparison of neuropsychological side effects between contemporary radiofrequency ablative neurosurgery for psychiatric disorders and conventional neurosurgical procedures: Systematic review and meta-analysis
dc.typeReview Article
dspace.entity.typePublication

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