The effects of maternal high fat diet on the lingual CD36 lipid sensors of the offspring sprague dawley rats

Basit Öğe Kaydı
dc.authorid0000-0002-3644-5066en_US
dc.authorscopusid57205248760en_US
dc.authorwosidAAY-3447-2021en_US
dc.contributor.authorGünalan, Elif
dc.contributor.authorKaragöz, Meyli Ezgi
dc.contributor.authorYılmaz, Bayram
dc.contributor.authorGemici, Burcu
dc.date.accessioned2021-12-10T09:35:48Z
dc.date.available2021-12-10T09:35:48Z
dc.date.issued2021en_US
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractBackground: Recent studies have demonstrated that CD36 lingual fat sensor has a vital role in fat sensation and high fat diet (HFD) causes dysfunctions in oro-gustatory lipid sensors. Objective: This study aims to investigate the effects of HFD during maternal and /or maturation period on lingual CD36 expression in offspring rats. Methods: Initially, female Sprague Dawley rats were familiarized to experimental diets. After the mating period, pregnant rats were fed with control (C) and HFD during the maternal period. Then, offsprings in each group were fed with C and HFD during the maturation period (120 days). Daily caloric intake and weekly weight measurements of the offspring rats were followed. The plasma insulin and leptin levels were determined with ELISA. Blood glucose and triglyceride levels were measured. The protein and mRNA expressions of CD36 in the circumvallate papillae (CVP) were determined by western blotting, immunofluorescence, and RT-PCR. Also, alpha-gustducin was used as taste marker. Results: According to biochemical measurements, HFD/HFD group offsprings have significantly increased plasma insulin and leptin concentrations compared to C/C group (p<0.05 and p<0.01, respectively). CD36 protein expressions in CVP were significantly lower in HFD/HFD than C/HFD and HFD/C groups (p<0.05). Consistently, CD36 in taste buds had weak immunofluorescence signal in HFD/HFD group. However, mRNA transcripts level of CD36 in HFD/HFD group were significantly higher than C/HFD group (p<0.05). Conclusion: This study suggests that HFD exposure during both maternal and/or maturation period may affect the expression of lingual taste sensor level.en_US
dc.identifier.citationGunalan, E., Karagoz, M. E., Yilmaz, B., & Gemici, B. (Mar 2021). The Effects of Maternal High Fat Diet on the Lingual CD36 Lipid Sensors of the Offspring Sprague Dawley Rats. Metabolism-Clinical And Experimental, 116, pp. 12-13. https://doi.org/10.1016/j.metabol.2020.154497en_US
dc.identifier.doi10.1016/j.metabol.2020.154497en_US
dc.identifier.endpage13en_US
dc.identifier.startpage12en_US
dc.identifier.urihttps://doi.org/10.1016/j.metabol.2020.154497
dc.identifier.urihttps://hdl.handle.net/20.500.13055/77
dc.identifier.volume116en_US
dc.identifier.wosWOS:000614658000031en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorGünalan, Elif
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMetabolismen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCD36en_US
dc.subjectHigh Fat Dieten_US
dc.subjectFat Exposureen_US
dc.subjectMaternal Dieten_US
dc.titleThe effects of maternal high fat diet on the lingual CD36 lipid sensors of the offspring sprague dawley ratsen_US
dc.typeConference Objecten_US
dspace.entity.typePublication

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
1-s2.0-S0026049520303619-main.pdf
Boyut:
65.71 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Beslenme ve Diyetetik Bölümü Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu