Liposomes loaded with activatable disulfide bridged photosensitizer: Towards targeted and effective photodynamic therapy on breast cancer cells

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dc.authorid0000-0002-6424-7411en_US
dc.contributor.authorGök Yurttaş, Asiye
dc.contributor.authorGökduman, Kurtuluş
dc.contributor.authorHekim, Nezih
dc.date.accessioned2021-12-21T12:59:57Z
dc.date.available2021-12-21T12:59:57Z
dc.date.issued2022en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Biyokimya Ana Bilim Dalıen_US
dc.description.abstractThe motivation of the current study is to develop a strategy providing targeted and effective photodynamic therapy (PDT) on breast cancer cells by eliminating the limitations of PDT. For this purpose, a disulfide bridged phthalocyanine with favorable wavelength absorbance that is activatable in cancer cells was synthesized and encapsulated in liposome nanoparticles. The synthesized molecule was characterized using Fourier transform-infrared (FT-IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, Matrix-Assisted Laser Desorption/Ionization Time of Flight (MALDI-TOF) Mass Spectrometry, Ultraviolet-visible (UV-Vis) spectrophotometry, and particle size analyzer; and the nano-formulation was tested on MCF-7 breast cancer cell line using MTT assay, fluorescence microscopy, and flow cytometry. The results have illustrated that the synthesized disulfide bridged phthalocyanine has a therapeutically active wavelength absorbance value (685 nm), the liposome nanoparticles with the favorable characteristics (average size of 167.6 nm and polydispersity index (PDI) of 0.108) containing the synthesized disulfide bridged phthalocyanine have low dark toxicity, and significant light toxicity (P < 0.001 vs. dark toxicity) characterized with significant apoptosis (p < 0.05 vs. control group). Thus, for further investigations, these results suggest the great potential of the nano-formulation towards targeted and effective PDT on breast cancer cells.en_US
dc.identifier.citationYurttaş, AG., Gökduman, K., & Hekim, K. (15 Feb 2022). Liposomes loaded with activatable disulfide bridged photosensitizer: Towards targeted and effective photodynamic therapy on breast cancer cells. Biointerface Research in Applied Chemistry, 12(1), pp. 304-325. https://doi.org/10.33263/BRIAC121.304325en_US
dc.identifier.doi10.33263/BRIAC121.304325en_US
dc.identifier.endpage325en_US
dc.identifier.issue1en_US
dc.identifier.startpage304en_US
dc.identifier.urihttps://doi.org/10.33263/BRIAC121.304325
dc.identifier.urihttps://hdl.handle.net/20.500.13055/101
dc.identifier.volume12en_US
dc.identifier.wosWOS:000646310900024en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Indexen_US
dc.institutionauthorGök Yurttaş, Asiye
dc.language.isoenen_US
dc.publisherAMG Transcend Associationen_US
dc.relation.ispartofBiointerface Research in Applied Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPhthalocyanineen_US
dc.subjectPhotodynamic Therapyen_US
dc.subjectTumor-Specific Activationen_US
dc.subjectDisulfide-Bridged Photosensitizeren_US
dc.subjectLiposomeen_US
dc.titleLiposomes loaded with activatable disulfide bridged photosensitizer: Towards targeted and effective photodynamic therapy on breast cancer cellsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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