Molecular docking analysis of PVDF membrane against human Erα, EGFR, CDK2, mTOR, and HSP90 proteins
Yükleniyor...
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Academic Perspective Procedia
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Porous membranes are used in biological and chemical systems and industrial applications. Polyvinylidene fluoride film (PVDF) membrane is a commercial membrane used in drug delivery, protein immobilization, food industry, tissue engineering, and medical devices. Because of providing a large surface area in this study PVDF membrane is used. Molecular docking is a molecular modeling simulation software especially used to determine protein-ligand interactions. The aim of the study is to determine the interaction of hydrophobic PVDF membranes on Erα, EGFR, CDK2, mTOR, and HSP90 proteins by docking method and to examine its potential as a possible drug carrier. The three-dimensional structure of the receptors has been acquired from the RCSB protein data bank and is docked with 3D PubChem of PVDF using AutoDock 1.5.6 software. The results have shown that the PVDF membrane had the best docking score for mTOR between the investigated proteins.
Açıklama
Anahtar Kelimeler
PVDF Membrane, Mtor, Drug Carrier, Molecular Docking
Kaynak
10th International Symposium on Innovative Technologies in Engineering and Science
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
3
Künye
Ata, F. K. & Özevci, G. (2022). Molecular docking analysis of PVDF membrane against human Erα, EGFR, CDK2, mTOR, and HSP90 proteins. 10th International Symposium on Innovative Technologies in Engineering and Science içinde (pp. 530-536). Bursa: Academic Perspective Procedia. https://doi.org/10.33793/acperpro.05.03.14021
