Management of neuroleptic malignant syndrome induced by paliperidone: A case report of multidisciplinary treatment approaches, including apomorphine and electroconvulsive therapy

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dc.authorid0000-0002-0609-4269
dc.authorid0000-0001-5110-9768
dc.authorid0000-0003-2757-9641
dc.authorid0000-0002-8584-5488
dc.contributor.authorGültekin, Murat
dc.contributor.authorBenli, Şeyma
dc.contributor.authorDemirel Özsoy, Saliha
dc.contributor.authorDeğirmenci, Yıldız
dc.date.accessioned2025-06-24T08:00:42Z
dc.date.available2025-06-24T08:00:42Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractA 34-year-old female patient with a history of bipolar affective disorder, who had been receiving paliperidone 100 mg monthly and biperiden 3 mg daily for the past two years, was admitted to the emergency department with a three-day history of fever, altered consciousness, dysphagia, mutism, rigidity, inability to walk, inability to speak, and vacant, meaningless stares. It was noted that her last paliperidone injection was administered 12 days before the hospitalization. Vital signs revealed a fever of 38.1°C, mild tachycardia, and normal blood pressure. Laboratory tests indicated leukocytosis and an elevated serum creatine kinase (CK) level of 1098 U/L (normal range: 39-308 U/L), suggesting muscle breakdown. Neurological examination revealed excessive sweating, confusion, rigidity, and dysphagia. A written informed consent was obtained from the patient.
dc.identifier.citationGültekin, M., Benli, Ş., Demirel Özsoy, S., & Değirmenci, Y. (2025). Management of neuroleptic malignant syndrome induced by paliperidone: A case report of multidisciplinary treatment approaches, including apomorphine and electroconvulsive therapy. Turkish Journal of Neurology, 31(2), pp. 244-246. https://doi.org/10.55697/tnd.2025.281
dc.identifier.doi10.55697/tnd.2025.281
dc.identifier.endpage246
dc.identifier.issn3023-7874
dc.identifier.issue2
dc.identifier.startpage244
dc.identifier.urihttps://doi.org/10.55697/tnd.2025.281
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1010
dc.identifier.volume31
dc.institutionauthorDeğirmenci, Yıldız
dc.institutionauthorid0000-0002-8584-5488
dc.language.isoen
dc.publisherTürk Nöroloji Derneği
dc.relation.ispartofTurkish Journal of Neurology
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleManagement of neuroleptic malignant syndrome induced by paliperidone: A case report of multidisciplinary treatment approaches, including apomorphine and electroconvulsive therapy
dc.typeLetter
dspace.entity.typePublication

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