Role of S100B, neuron-specific enolase, and adrenomedullin in differentiating central and peripheral vertigo

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dc.authorid0009-0008-0174-5801
dc.authorid0000-0002-6186-6110
dc.authorid0000-0003-0782-390X
dc.authorid0000-0003-3674-133X
dc.authorid0009-0002-0167-5870
dc.authorid0000-0002-4760-0076
dc.authorid0000-0002-0110-3533
dc.contributor.authorOnur, Bahaeddin
dc.contributor.authorÖzdemir, Serdar
dc.contributor.authorKoçak, Mehmet
dc.contributor.authorÜnal Akoğlu, Ebru
dc.contributor.authorDemir, Hasan
dc.contributor.authorCimilli Öztürk, Tuba
dc.contributor.authorOnur, Özge Ecmel
dc.date.accessioned2026-05-12T13:11:45Z
dc.date.available2026-05-12T13:11:45Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Ana Bilim Dalı
dc.description.abstractAim: This study aimed to evaluate S100B, adrenomedullin (ADM), and neuron-specific enolase (NSE) as diagnostic biomarkers to differentiate central and peripheral vertigo in patients with dizziness. Methods: A prospective cohort study was conducted with 88 patients (58% women) presenting with dizziness. Patients were categorized based on MRI findings into two groups: those with acute lesions (central vertigo) and those without lesions (peripheral vertigo). S100B, ADM, and NSE levels were measured and compared between the groups to assess their diagnostic value for central vertigo. Results: Significant differences were found in S100B, NSE, and ADM levels between the central and peripheral vertigo groups (p=0.003, 0.008, and 0.010, respectively). Factors predicting MRI-detected lesions included age, mean arterial pressure, movement-induced and positional vertigo, neurological findings, history of hypertension, lack of response to symptomatic treatment, and elevated S100B, ADM, and NSE levels. Logistic regression analysis identified the lack of response to symptomatic treatment as the only significant predictor (p=0.0148). Conclusion: S100B, ADM, and NSE levels significantly differ between central and peripheral vertigo, suggesting their potential as diagnostic biomarkers. However, only the lack of response to symptomatic treatment was a significant predictor. Further research is needed to validate these biomarkers alongside clinical assessments and imaging.
dc.identifier.citationOnur, B., Özdemir, S., Koçak, M., Ünal Akoğlu, E., Demir, H., Cimilli Öztürk, T., & Onur, Ö. E. (2026). Role of S100B, neuron-specific enolase, and adrenomedullin in differentiating central and peripheral vertigo. Annals of Clinical and Analytical Medicine, 17(5), pp. 478-483. https://doi.org/10.4328/ACAM.22325
dc.identifier.doi10.4328/ACAM.22325
dc.identifier.endpage483
dc.identifier.issn2667-663X
dc.identifier.issue5
dc.identifier.startpage478
dc.identifier.urihttps://doi.org/10.4328/ACAM.22325
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1477
dc.identifier.volume17
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Index
dc.institutionauthorOnur, Bahaeddin
dc.institutionauthorid0009-0008-0174-5801
dc.language.isoen
dc.publisherBayrakol Medical Publisher
dc.relation.ispartofAnnals of Clinical and Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdrenomedullin
dc.subjectNeuron-Specific Enolase
dc.subjectS100B Protein
dc.titleRole of S100B, neuron-specific enolase, and adrenomedullin in differentiating central and peripheral vertigo
dc.typeArticle
dspace.entity.typePublication

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