Adenomyosis and uterine fibroids: Two distinct yet overlapping clinical entities

Basit Öğe Kaydı
dc.authorid0000-0002-5928-3565
dc.authorid0000-0001-5420-4277
dc.authorid0000-0002-0443-0572
dc.authorid0000-0003-0515-1951
dc.authorid0000-0001-6111-9302
dc.authorid0000-0002-5638-3675
dc.authorid0000-0002-5061-8007
dc.authorid0009-0007-9979-9287
dc.authorid0000-0001-8426-8490
dc.contributor.authorPecorella, Giovanni
dc.contributor.authorMorciano, Andrea
dc.contributor.authorMedvediev, Mykhailo
dc.contributor.authorSparic, Radmila
dc.contributor.authorBıyık, İsmail
dc.contributor.authorAydın, Gerçek
dc.contributor.authorBaldini, Giorgio Maria
dc.contributor.authorMalvasi, Antonio
dc.contributor.authorStojković, Marta
dc.contributor.authorTinelli, Andrea
dc.date.accessioned2026-10-27T14:00:41Z
dc.date.available2026-10-27T14:00:41Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractAdenomyosis and uterine fibroids are among the most common benign uterine disorders in women of reproductive age and represent major causes of abnormal uterine bleeding, pelvic pain, and infertility. Despite their distinct histopathological features, they frequently coexist and share several hormonal and molecular mechanisms, making diagnosis and treatment challenging. This narrative review examines the current evidence on their epidemiology, pathophysiology, clinical presentation, imaging characteristics, reproductive impact, and therapeutic management, with particular attention to the role of imaging in the differential diagnosis and management of coexisting disease. A non-systematic narrative review of the literature was conducted using PubMed/MEDLINE and Scopus. Relevant original studies, systematic reviews, meta-analyses, consensus statements, and clinical guidelines addressing adenomyosis, uterine fibroids, imaging, fertility, and treatment were considered. Additional references were identified through manual screening of the bibliographies of the retrieved articles. Although adenomyosis and uterine fibroids differ in their biological origin and morphological appearance, they commonly present with overlapping symptoms, including heavy menstrual bleeding, dysmenorrhea, chronic pelvic pain, and reproductive dysfunction. Transvaginal ultrasound remains the first-line imaging modality, whereas magnetic resonance imaging is particularly valuable in complex cases, lesion characterization, and preoperative assessment. Accurate imaging phenotyping may help distinguish isolated from coexisting disease and support individualized medical, surgical, or minimally invasive treatment planning. A structured imaging-based approach integrated with clinical findings and reproductive goals may improve disease characterization and support individualized management of adenomyosis and uterine fibroids. Further standardization of imaging criteria and validation of emerging diagnostic technologies may improve patient stratification and treatment selection.
dc.identifier.citationPecorella, G., Morciano, A., Medvediev, M., Sparic, R., Bıyık, İ., Aydın, G., Baldini, G. M., Malvasi, A., Stojković, M., & Tinelli, A. (2026). Adenomyosis and uterine fibroids: Two distinct yet overlapping clinical entities. Diagnostics, 16(18), pp. 1-18. https://doi.org/10.3390/diagnostics16182968
dc.identifier.doi10.3390/diagnostics16182968
dc.identifier.endpage18
dc.identifier.issn2075-4418
dc.identifier.issue18
dc.identifier.pmidPMID: 42793753
dc.identifier.scopus2-s2.0-105051784087
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.3390/diagnostics16182968
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1685
dc.identifier.volume16
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorAydın, Gerçek
dc.institutionauthorid0000-0002-5638-3675
dc.language.isoen
dc.publisherMDPI Publishing
dc.relation.ispartofDiagnostics
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdenomyosis
dc.subjectUterine Fibroids
dc.subjectTransvaginal Ultrasound
dc.subjectMagnetic Resonance Imaging
dc.subjectDifferential Diagnosis
dc.subjectFertility
dc.subjectPersonalized Management
dc.subjectMUSA
dc.titleAdenomyosis and uterine fibroids: Two distinct yet overlapping clinical entities
dc.typeReview Article
dspace.entity.typePublication

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
Tam Metin / Full Text.pdf
Boyut:
1.37 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu