Spectrophotometric determination of erdosteine at capsule dosage forms

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dc.authorid0000-0002-5840-7386en_US
dc.authorscopusid6701367993en_US
dc.authorwosidFZV-5400-2022en_US
dc.contributor.authorÖnal, Cem
dc.contributor.authorDinçel, Demet
dc.date.accessioned2021-12-16T15:42:50Z
dc.date.available2021-12-16T15:42:50Z
dc.date.issued2021en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalıen_US
dc.description.abstractObjective: Two simple, rapid and sensitive methods were developed for determination of Erdosteine (ERD) in pure form as well as in their pharmaceutical formulations. Methods: The methods were based on formation of colored charge transfer complexes with ERD with chloranil (CA) and 7,7,8,8-tetracyanoquinodimethane (TCNQ). The obtained charge-transfer complexes were measured at 454 and 843 nm for CA and TCNQ methods, respectively. Optimization of different experimental conditions were investigated. Results: Beer's plots were obeyed in a general concentration range of 10-500 mu g mL(-1) and 20-600 mu g mL(-1) for CA and TCNQ methods, respectively. The validity of methods in terms of specificity, linearity, accuracy, precision, limit of detection and limit of quantitation were evaluated. Conclusion: The methods were applied successfully in the determination of ERD in capsule dosage forms. Developed new spectrophotometric methods have been found to be very practical and practical. The lack of complex sample preparation increases the applicability of the method.en_US
dc.identifier.citationÖnal, C. & Dinçel, D. (2021). Spectrophotometric Determination of Erdosteine at Capsule Dosage Forms. Bezmialem Science, 9(1), pp. 20-24. https://doi.org/10.14235/bas.galenos.2020.3916en_US
dc.identifier.doi10.14235/bas.galenos.2020.3916en_US
dc.identifier.endpage24en_US
dc.identifier.issue1en_US
dc.identifier.startpage20en_US
dc.identifier.trdizinid425309
dc.identifier.urihttps://doi.org/10.14235/bas.galenos.2020.3916
dc.identifier.urihttps://hdl.handle.net/20.500.13055/87
dc.identifier.volume9en_US
dc.identifier.wosWOS:000613760800005en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Indexen_US
dc.institutionauthorÖnal, Cem
dc.language.isoenen_US
dc.publisherGalenosen_US
dc.relation.ispartofBezmialem Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectErdosteineen_US
dc.subjectCharge Transfer Complexen_US
dc.subjectTCNQen_US
dc.subjectCAen_US
dc.subjectSpectrophotometryen_US
dc.subjectValidationen_US
dc.subjectPharmaceutical Formulationen_US
dc.titleSpectrophotometric determination of erdosteine at capsule dosage formsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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