Spectrofluorimetric analysis of ticagrelor in pharmaceutical formulations and spiked human plasma using 1-dimethylaminonaphthalene-5-sulphonyl chloride reagent

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dc.authorid0000-0002-5840-7386en_US
dc.authorscopusid6701367993en_US
dc.authorwosidFZV-5400-2022en_US
dc.contributor.authorÖnal, Cem
dc.contributor.authorKepekçi Tekkeli, Şerife Evrim
dc.date.accessioned2021-12-16T11:15:43Z
dc.date.available2021-12-16T11:15:43Z
dc.date.issued2020en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalıen_US
dc.description.abstractA sensitive method is presented for the determination of the ticagrelor (TCG) in human plasma and pharmaceutical preparations using 5-(dimethylamino)naphthalene-1-sulfonyl chloride (dansyl chloride). Ticagrelor contains a secondary amino group which reacts with dansyl chloride in the presence of 0.5 M sodium bicarbonate (pH 10) to yield a highly fluorescent derivative that is measured at 445 nm after excitation at 340 nm. Different experimental parameters affecting the fluorescence intensities were carefully studied and optimized. The proposed method was also validated according to ICH guidelines. The fluorescence concentration plot was rectilinear over the range of 20.0-200.0 ng mL(-1), with a coefficient of determination of 0.9999 with a limit of detection (LOD) of 0.14 ng mL(-1) and the limit of quantitation (LOQ) of 0.46 ng mL(-1). The proposed method was applied successfully to the analysis of TCG in spiked human plasma and pharmaceutical dosage forms with good accuracy and precision.en_US
dc.identifier.citationÖnal, C., & Kepekçi Tekkeli, Ş. E. (2020). Spectrofluorimetric analysis of ticagrelor in pharmaceutical formulations and spiked human plasma using 1-dimethylaminonaphthalene-5-sulphonyl chloride reagent. Journal of Research in Pharmacy, 24(5), pp. 765-773. https://doi.org/10.35333/jrp.2020.229en_US
dc.identifier.doi10.35333/jrp.2020.229en_US
dc.identifier.endpage773en_US
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85092737267en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage765en_US
dc.identifier.urihttps://doi.org/10.35333/jrp.2020.229
dc.identifier.urihttps://hdl.handle.net/20.500.13055/85
dc.identifier.volume24en_US
dc.identifier.wosWOS:000570795700015en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Indexen_US
dc.institutionauthorÖnal, Cem
dc.language.isoenen_US
dc.publisherMarmara University Pressen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTicagreloren_US
dc.subjectAntiplateleten_US
dc.subjectSpectrofluorimetryen_US
dc.subjectDansyl Chlorideen_US
dc.subjectDerivatizationen_US
dc.subjectValidation;en_US
dc.subjectPharmaceutical Preparationsen_US
dc.subjectPlasma Samplesen_US
dc.titleSpectrofluorimetric analysis of ticagrelor in pharmaceutical formulations and spiked human plasma using 1-dimethylaminonaphthalene-5-sulphonyl chloride reagenten_US
dc.typeArticleen_US
dspace.entity.typePublication

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