Determination of apigenin in cosmetics containing chamomile by high-performance liquid chromatography with ultraviolet detection (HPLC-UV)

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dc.authorid0000-0002-1871-017Xen_US
dc.authorscopusid49964600400en_US
dc.contributor.authorSerim, Ecem
dc.contributor.authorCeylan, Burhan
dc.contributor.authorKepekçi Tekkeli, Şerife Evrim
dc.date.accessioned2023-01-03T09:13:37Z
dc.date.available2023-01-03T09:13:37Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalıen_US
dc.description.abstractA simple, rapid, and precise high performance liquid chromatography (HPLC) method was developed to determine the flavonoid apigenin in cosmetic products containing chamomile extracts. A C18 column was used as stationary phase and 70:30 ethanol:water was used as mobile phase with a 1 mL/min flow rate and isocratic elution. The temperature was stabilized at 25 degrees C during the separation. The injection volume was 50 mu L. The apigenin peak was eluted at 4.15 +/- 0.4 min. The method was validated according to International Conference on Harmonisation (ICH) criteria in terms of linearity, limit of detection, limit of quantitation, selectivity, sensitivity, robustness, accuracy, and precision. The limits of detection and quantitation were 0.060 and 0.2 mu g/mL respectively. The linear range was from 0.2 to 20 mu g/mL. The relative standard deviation values for intraday and interday analyses were less than 1.64%. The developed procedure was applied to the analysis of various cosmetic products. It is expected that the method is suitable for routine analysis, quality control and standardization of cosmetic products for apigenin.en_US
dc.identifier.citationSerim, E., Ceylan, B. & Kepekçi Tekkeli, Ş. E. (2023). Determination of apigenin in cosmetics containing chamomile by high-performance liquid chromatography with ultraviolet detection (HPLC-UV). Analytical Letters, 56(13), pp. 2113-2122. https://doi.org/10.1080/00032719.2022.2155180en_US
dc.identifier.doi10.1080/00032719.2022.2155180en_US
dc.identifier.endpage2122en_US
dc.identifier.issn0003-2719
dc.identifier.issn1532-236X
dc.identifier.issue13en_US
dc.identifier.scopus2-s2.0-85144232809en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2113en_US
dc.identifier.urihttps://doi.org/10.1080/00032719.2022.2155180
dc.identifier.urihttps://hdl.handle.net/20.500.13055/362
dc.identifier.volume56en_US
dc.identifier.wosWOS:000899115200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorKepekçi Tekkeli, Şerife Evrim
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofAnalytical Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApigeninen_US
dc.subjectChamomileen_US
dc.subjectFlavonoidsen_US
dc.subjectHigh-Performance Liquidchromatography Withultraviolet Detection(HPLC-UV)en_US
dc.titleDetermination of apigenin in cosmetics containing chamomile by high-performance liquid chromatography with ultraviolet detection (HPLC-UV)en_US
dc.typeArticleen_US
dspace.entity.typePublication

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